Charalabos Pothoulakis

Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles

Affiliated withUniversity of California, Los Angeles

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2019

Other Publications

Article	Year
Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 11390763	1998
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. The Journal of biological chemistry\| PubMed ID: 11729192	2002
Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology\| PubMed ID: 11875005	2002
Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. Carcinogenesis\| PubMed ID: 11895868	2002
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology\| PubMed ID: 11910356	2002
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum. Gastroenterology\| PubMed ID: 12145804	2002
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. The Biochemical journal\| PubMed ID: 12169092	2002
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. American journal of physiology. Cell physiology\| PubMed ID: 12490434	2003
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. American journal of physiology. Cell physiology\| PubMed ID: 12584113	2003
Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12594338	2003
Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology\| PubMed ID: 12612907	2003
Development of microbial-human enterocyte interaction: cholera toxin. Pediatric research\| PubMed ID: 12736381	2003
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology\| PubMed ID: 12891543	2003
A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 12893626	2003
Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. Expert opinion on therapeutic targets\| PubMed ID: 14498821	2003
MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 15069060	2004
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15159534	2004
Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 15247267	2004
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. The Journal of biological chemistry\| PubMed ID: 15319441	2004
Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrobial agents and chemotherapy\| PubMed ID: 15388461	2004
Bacterial infections: small intestine and colon. Current opinion in gastroenterology\| PubMed ID: 15699889	2003
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15746211	2005
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Molecular pharmacology\| PubMed ID: 15755906	2005
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology\| PubMed ID: 15765411	2005
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. The Journal of biological chemistry\| PubMed ID: 15767259	2005
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology\| PubMed ID: 15825081	2005
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15917399	2005
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16157881	2005
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology\| PubMed ID: 16344056	2005
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochemical and biophysical research communications\| PubMed ID: 16529714	2006
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16549770	2006
Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. Journal of cellular biochemistry\| PubMed ID: 16552751	2006
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585602	2006
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 16644730	2006
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology\| PubMed ID: 16697737	2006
Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. The Journal of biological chemistry\| PubMed ID: 16816386	2006
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16818780	2006
Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides\| PubMed ID: 16872719	2006
Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920976	2006
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16985259	2007
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines. Neuroimmunomodulation\| PubMed ID: 17077645	2006
Immunomodulatory properties of substance P: the gastrointestinal system as a model. Annals of the New York Academy of Sciences\| PubMed ID: 17192554	2006
Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. International journal of cancer. Journal international du cancer\| PubMed ID: 17230532	2007
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17264209	2007
Role of neuropeptides in inflammatory bowel disease. Inflammatory bowel diseases\| PubMed ID: 17343284	2007
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology\| PubMed ID: 17408650	2007
Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut\| PubMed ID: 17412781	2007
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17563389	2007
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology\| PubMed ID: 17570216	2007
Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. Gastroenterology\| PubMed ID: 17854595	2007
Obesity, innate immunity and gut inflammation. Current opinion in gastroenterology\| PubMed ID: 17906444	2007
Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters. Antimicrobial agents and chemotherapy\| PubMed ID: 18195066	2008
Substance P as a novel anti-obesity target. Gastroenterology\| PubMed ID: 18325388	2008
Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. Gastroenterology\| PubMed ID: 18395088	2008
Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. Endocrinology\| PubMed ID: 18403481	2008
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. Infection and immunity\| PubMed ID: 18411291	2008
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology\| PubMed ID: 18538140	2008
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. The American journal of pathology\| PubMed ID: 18599605	2008
Melanin-concentrating hormone as a mediator of intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18650383	2008
Neuropeptides, mesenteric fat, and intestinal inflammation. Annals of the New York Academy of Sciences\| PubMed ID: 19076372	2008
Substance P, obesity, and gut inflammation. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 19104238	2009
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology\| PubMed ID: 19249394	2009
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19282377	2009
Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 19404271	2009
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19443690	2009
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin. Experimental cell research\| PubMed ID: 19481075	2009
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology\| PubMed ID: 19482027	2009
Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes. Endocrinology\| PubMed ID: 19628576	2009
Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. The Journal of nutrition\| PubMed ID: 19675103	2009
Serotonin has a critical role in the pathogenesis of experimental colitis. Gastroenterology\| PubMed ID: 19789088	2009
The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. International journal of cancer. Journal international du cancer\| PubMed ID: 19876926	2010
Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis. Gastroenterology\| PubMed ID: 20206175	2010
TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. The Journal of biological chemistry\| PubMed ID: 20452988	2010
The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20501448	2009
Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. The Journal of biological chemistry\| PubMed ID: 20696758	2010
Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology\| PubMed ID: 20732324	2010
TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. The Journal of biological chemistry\| PubMed ID: 20855887	2010
Substance P modulates colitis-associated fibrosis. The American journal of pathology\| PubMed ID: 20889569	2010
Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 21212273	2011
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PloS one\| PubMed ID: 21264313	2011
Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology\| PubMed ID: 21277852	2011
Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology\| PubMed ID: 21467195	2011
Neuropeptide - adipose tissue communication and intestinal pathophysiology. Current pharmaceutical design\| PubMed ID: 21548874	2011
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 21630261	2012
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21719739	2011
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology\| PubMed ID: 21762664	2011
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology\| PubMed ID: 21806946	2011
The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity. Antimicrobial agents and chemotherapy\| PubMed ID: 21807975	2011
Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nature medicine\| PubMed ID: 21857653	2011
The effects of acute and chronic psychological stress on bladder function in a rodent model. Urology\| PubMed ID: 21868072	2011
Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. The American journal of pathology\| PubMed ID: 21945803	2011
Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology\| PubMed ID: 22009727	2011
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell\| PubMed ID: 22118463	2011
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. The American journal of pathology\| PubMed ID: 22138299	2012
Serum and colonic mucosal immune markers in irritable bowel syndrome. The American journal of gastroenterology\| PubMed ID: 22158028	2012
Clostridial toxins: sensing a target in a hostile gut environment. Gut microbes\| PubMed ID: 22356854	2012
Adipose tissue and inflammatory bowel disease pathogenesis. Inflammatory bowel diseases\| PubMed ID: 22407798	2012
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by Î²-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin re... The Journal of biological chemistry\| PubMed ID: 22416137	2012
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therapeutic advances in gastroenterology\| PubMed ID: 22423260	2012
Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22723263	2012
The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut\| PubMed ID: 22760006	2012
Antimicrobial Peptides and Colitis. Current pharmaceutical design\| PubMed ID: 22950497	2012