Tomohiro Miyasaka

Department of Neuropathology, Doshisha University

Affiliated withDoshisha University Nihon University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19036972	2008
Microtubule destruction induces tau liberation and its subsequent phosphorylation. FEBS letters\| PubMed ID: 20561519	2010
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 21554501	2011
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature communications\| PubMed ID: 24108142	2013
The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. PloS one\| PubMed ID: 24587039	2014
Immunostaining of oxidized DJ-1 in human and mouse brains. Journal of neuropathology and experimental neurology\| PubMed ID: 24918637	2014
Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. Journal of neurochemistry\| PubMed ID: 26134402	2015
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature communications\| PubMed ID: 26671725	2015
Curcumin improves tau-induced neuronal dysfunction of nematodes. Neurobiology of aging\| PubMed ID: 26923403	2016
The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of Dementia. Frontiers in molecular neuroscience\| PubMed ID: 28082867	2016
Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry. Acta neuropathologica communications\| PubMed ID: 29037261	2017
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. The Journal of biological chemistry\| PubMed ID: 29196605	2018
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy. Frontiers in neuroscience\| PubMed ID: 29973863	2018
Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin. Scientific reports\| PubMed ID: 30104666	2018
Distribution of endogenous normal tau in the mouse brain. The Journal of comparative neurology\| PubMed ID: 30408165	2019
Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31235644	2019
Regulatory mechanisms for the axonal localization of tau protein in neurons. Molecular biology of the cell\| PubMed ID: 31364926	2019
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem cell reports\| PubMed ID: 31543469
Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies. Biochemical and biophysical research communications\| PubMed ID: 31699369	2020
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Nature communications\| PubMed ID: 31919357	2020
A potential defense mechanism against amyloid deposition in cerebellum. Biochemical and biophysical research communications\| PubMed ID: 33340762	2021
Quantitative fractionation of tissue microtubules with distinct biochemical properties reflecting their stability and lability. Biochemical and biophysical research communications\| PubMed ID: 33992960	2021
Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo. Human molecular genetics\| PubMed ID: 34137825	2021
Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 34894926	2022
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model. eLife\| PubMed ID: 35471147	2022
Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission. Communications biology\| PubMed ID: 35768587	2022
The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes. Frontiers in cell and developmental biology\| PubMed ID: 36274848	2022
Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes. Glia\| PubMed ID: 36565228	2023
The senile plaque: Morphological differences in APP knock-in mice brains by fixatives. Brain and behavior\| PubMed ID: 36879381	2023
Mass Spectrometry Imaging in Alzheimer's Disease. Brain connectivity\| PubMed ID: 36905365	2023