Philippe Froguel

Genomics, Faculty of Medicine Imperial College London

Affiliated withFaculty of Medicine Imperial College London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2013

Other Publications

Article	Year
Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS clinical trials\| PubMed ID: 16871334	2006
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. The New England journal of medicine\| PubMed ID: 16885549	2006
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochemical and biophysical research communications\| PubMed ID: 16920065	2006
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to c... Diabetes\| PubMed ID: 16936202	2006
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes\| PubMed ID: 16936214	2006
Genetics of obesity and the prediction of risk for health. Human molecular genetics\| PubMed ID: 16987875	2006
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Diabetes\| PubMed ID: 17003356	2006
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes\| PubMed ID: 17003360	2006
Impact of a CART promoter genetic variation on plasma lipid profile in a general population. Molecular genetics and metabolism\| PubMed ID: 17008116	2007
TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes\| PubMed ID: 17065361	2006
Genotype-by-nutrient interactions assessed in European obese women. A case-only study. European journal of nutrition\| PubMed ID: 17080261	2006
Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert reviews in molecular medicine\| PubMed ID: 17112391	2006
No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. European journal of human genetics : EJHG\| PubMed ID: 17164796	2007
Comment on "A common genetic variant is associated with adult and childhood obesity". Science (New York, N.Y.)\| PubMed ID: 17218508	2007
Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 17243864	2007
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature medicine\| PubMed ID: 17268472	2007
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature\| PubMed ID: 17293876	2007
Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes\| PubMed ID: 17327457	2007
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes\| PubMed ID: 17327460	2007
Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochemical and biophysical research communications\| PubMed ID: 17383612	2007
Coexistence in the same family of both focal and diffuse forms of hyperinsulinism. Diabetes care\| PubMed ID: 17384337	2007
New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes\| PubMed ID: 17389331	2007
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 17389697	2007
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 17476472	2007
Variation in FTO contributes to childhood obesity and severe adult obesity. Nature genetics\| PubMed ID: 17496892	2007
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Human molecular genetics\| PubMed ID: 17519222	2007
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nature genetics\| PubMed ID: 17529978	2007
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population. BMC medical genetics\| PubMed ID: 17593304	2007
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. BMC medical genetics\| PubMed ID: 17617923	2007
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Human molecular genetics\| PubMed ID: 17666407	2007
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. American journal of human genetics\| PubMed ID: 17668382	2007
Analysis of KLF transcription factor family gene variants in type 2 diabetes. BMC medical genetics\| PubMed ID: 17688680	2007
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. The Journal of clinical endocrinology and metabolism\| PubMed ID: 17698913	2007
Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population. Acta diabetologica\| PubMed ID: 17805473	2008
Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 17890495	2007
Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences. Endocrine development\| PubMed ID: 17923772	2007
A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. The Journal of clinical endocrinology and metabolism\| PubMed ID: 17971428	2008
Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in ... Diabetes\| PubMed ID: 17977952	2008
Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes\| PubMed ID: 17977958	2008
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18042720	2007
Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Stu... Diabetes\| PubMed ID: 18171712	2008
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 18210030	2008
Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring, Md.)\| PubMed ID: 18239663	2008
Neonatal hyperglycaemia and abnormal development of the pancreas. Best practice & research. Clinical endocrinology & metabolism\| PubMed ID: 18279778	2008
Evaluating the association of common PBX1 variants with type 2 diabetes. BMC medical genetics\| PubMed ID: 18312624	2008
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Human molecular genetics\| PubMed ID: 18325908	2008
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Human molecular genetics\| PubMed ID: 18325910	2008
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes\| PubMed ID: 18346985	2008
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Human molecular genetics\| PubMed ID: 18375449	2008
INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study. Obesity (Silver Spring, Md.)\| PubMed ID: 18388898	2008
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. European journal of human genetics : EJHG\| PubMed ID: 18398438	2008
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). Diabetes care\| PubMed ID: 18411240	2008
Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians. Diabetes\| PubMed ID: 18430866	2008
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocrine reviews\| PubMed ID: 18436708	2008
TCF7L2 genetic defect and type 2 diabetes. Current diabetes reports\| PubMed ID: 18445358	2008
Inflammation is associated with a decrease of lipogenic factors in omental fat in women. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 18448614	2008
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (New York, N.Y.)\| PubMed ID: 18451265	2008
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature genetics\| PubMed ID: 18454146	2008
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature genetics\| PubMed ID: 18454148	2008
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PloS one\| PubMed ID: 18461161	2008
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC medical genetics\| PubMed ID: 18498634	2008
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 bi... The Journal of clinical endocrinology and metabolism\| PubMed ID: 18505768	2008
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes\| PubMed ID: 18556336	2008
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes\| PubMed ID: 18559663	2008
Common nonsynonymous variants in PCSK1 confer risk of obesity. Nature genetics\| PubMed ID: 18604207	2008
Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes care\| PubMed ID: 18689695	2008
The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring, Md.)\| PubMed ID: 18719664	2008
The power of the extreme in elucidating obesity. The New England journal of medicine\| PubMed ID: 18753645	2008
Small deletion variants have stable breakpoints commonly associated with alu elements. PloS one\| PubMed ID: 18769679	2008
Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Pharmacogenetics and genomics\| PubMed ID: 18854778	2008
The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population. Obesity (Silver Spring, Md.)\| PubMed ID: 18948963	2009
Is obesity our genetic legacy? The Journal of clinical endocrinology and metabolism\| PubMed ID: 18987270	2008
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nature genetics\| PubMed ID: 19060909	2009
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). The Journal of infectious diseases\| PubMed ID: 19115949	2009
Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height. European journal of endocrinology / European Federation of Endocrine Societies\| PubMed ID: 19139030	2009
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature genetics\| PubMed ID: 19151714	2009
Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 19165163	2009
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Human genetics\| PubMed ID: 19184112	2009
Evaluating the association of common APOA2 variants with type 2 diabetes. BMC medical genetics\| PubMed ID: 19216768	2009
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 19255736	2009
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochemical and biophysical research communications\| PubMed ID: 19275893	2009
Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study. BMC medical genetics\| PubMed ID: 19292929	2009
A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 19300429	2009
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19... Diabetes\| PubMed ID: 19324940	2009
Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochemical and biophysical research communications\| PubMed ID: 19332024	2009
Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC medical genetics\| PubMed ID: 19368707	2009
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. Human molecular genetics\| PubMed ID: 19377085	2009
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes\| PubMed ID: 19389826	2009
Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes. Pediatric endocrinology reviews : PER\| PubMed ID: 19396026	2009
Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. Diabetes\| PubMed ID: 19401419	2009
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Human molecular genetics\| PubMed ID: 19498035	2009
The genetic contribution to non-syndromic human obesity. Nature reviews. Genetics\| PubMed ID: 19506576	2009
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes\| PubMed ID: 19542200	2009
Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors. Biotechnology journal\| PubMed ID: 19557797	2009
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. American journal of human genetics\| PubMed ID: 19559399	2009
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA : the journal of the American Medical Association\| PubMed ID: 19567438	2009
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. The Journal of clinical endocrinology and metabolism\| PubMed ID: 19602561	2009
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes\| PubMed ID: 19651812	2009
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits. Diabetes\| PubMed ID: 19651813	2009
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nature genetics\| PubMed ID: 19734900	2009
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). The Journal of infectious diseases\| PubMed ID: 19754311	2009
Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes\| PubMed ID: 19833892	2010
MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. The Journal of biological chemistry\| PubMed ID: 19843526	2009
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS genetics\| PubMed ID: 19851442	2009
Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Obesity (Silver Spring, Md.)\| PubMed ID: 19876004	2010
Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia. Obesity (Silver Spring, Md.)\| PubMed ID: 19893502	2010
Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY). Diabetes care\| PubMed ID: 19903754	2010
[Inputs from the genetics of fasting glucose: lessons for diabetes]. MÃ©decine sciences : M/S\| PubMed ID: 19951660	2009
Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes\| PubMed ID: 20007936	2010
Genome-wide association study identifies five loci associated with lung function. Nature genetics\| PubMed ID: 20010834	2010
PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women. BMC medical genetics\| PubMed ID: 20030815	2009
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. The American journal of clinical nutrition\| PubMed ID: 20032493	2010
Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population. Obesity facts\| PubMed ID: 20054193	2008
Analysis of the SIM1 contribution to polygenic obesity in the French population. Obesity (Silver Spring, Md.)\| PubMed ID: 20075856	2010
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature genetics\| PubMed ID: 20081857	2010
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature genetics\| PubMed ID: 20081858	2010
Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Clinical biochemistry\| PubMed ID: 20132806	2010
Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Molecular genetics and metabolism\| PubMed ID: 20138556	2010
Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. Journal of human genetics\| PubMed ID: 20186155	2010
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes\| PubMed ID: 20200315	2010
Inflammatory role of Toll-like receptors in human and murine adipose tissue. Mediators of inflammation\| PubMed ID: 20339530	2010
Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS letters\| PubMed ID: 20347812	2010
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature genetics\| PubMed ID: 20372150	2010
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS genetics\| PubMed ID: 20421936	2010
cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nature methods\| PubMed ID: 20512141	2010
Monogenic forms of diabetes mellitus: an update. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion\| PubMed ID: 20542223	2009
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature genetics\| PubMed ID: 20581827	2010
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors. Metabolism: clinical and experimental\| PubMed ID: 20619427	2011
Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes\| PubMed ID: 20622168	2010
Monogenic forms of diabetes mellitus: an update. EndocrinologÃa y nutriciÃ³n : Ã³rgano de la Sociedad EspaÃ±ola de EndocrinologÃa y NutriciÃ³n\| PubMed ID: 20629227	2009
Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. The Journal of infectious diseases\| PubMed ID: 20704485	2010
Evaluation of A2BP1 as an obesity gene. Diabetes\| PubMed ID: 20724578	2010
The emerging genetics of type 2 diabetes. Trends in molecular medicine\| PubMed ID: 20728409	2010
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature genetics\| PubMed ID: 20818381	2010
Common variants at 10 genomic loci influence hemoglobin Aâ‚(C) levels via glycemic and nonglycemic pathways. Diabetes\| PubMed ID: 20858683	2010
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature genetics\| PubMed ID: 20935629	2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics\| PubMed ID: 20935630	2010
Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects. Obesity (Silver Spring, Md.)\| PubMed ID: 20966904	2011
Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. PloS one\| PubMed ID: 21049026	2010
Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 21107268	2011
Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Annals of the New York Academy of Sciences\| PubMed ID: 21175686	2010
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations. Pediatric diabetes\| PubMed ID: 21214702	2011
Childhood obesity is associated with shorter leukocyte telomere length. The Journal of clinical endocrinology and metabolism\| PubMed ID: 21349907	2011
TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Human molecular genetics\| PubMed ID: 21357677	2011
Bio-Repository of DNA in stroke (BRAINS): a study protocol. BMC medical genetics\| PubMed ID: 21366918	2011
Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Annals of human genetics\| PubMed ID: 21401563	2011
Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. The Journal of biological chemistry\| PubMed ID: 21454707	2011
Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. American journal of medical genetics. Part A\| PubMed ID: 21465662	2011
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes\| PubMed ID: 21515849	2011
famCNV: copy number variant association for quantitative traits in families. Bioinformatics (Oxford, England)\| PubMed ID: 21546396	2011
Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. The Journal of biological chemistry\| PubMed ID: 21592955	2011
Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. Clinical chemistry\| PubMed ID: 21677093	2011
Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring, Md.)\| PubMed ID: 21720444	2012
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome medicine\| PubMed ID: 21745417	2011
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 21760635	2012
Characterization of the human SLC30A8 promoter and intronic enhancer. Journal of molecular endocrinology\| PubMed ID: 21798992	2011
ITIH-5 expression in human adipose tissue is increased in obesity. Obesity (Silver Spring, Md.)\| PubMed ID: 21852814	2012
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes\| PubMed ID: 21873549	2011
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature genetics\| PubMed ID: 21874001	2011
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature\| PubMed ID: 21881559	2011
Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study. Diabetes\| PubMed ID: 21911746	2011
Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. PloS one\| PubMed ID: 21980470	2011
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature genetics\| PubMed ID: 22001757	2011
Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. The Journal of biological chemistry\| PubMed ID: 22065581	2011
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS medicine\| PubMed ID: 22069379	2011
New gene functions in megakaryopoiesis and platelet formation. Nature\| PubMed ID: 22139419	2011
Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes\| PubMed ID: 22210313	2012
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes\| PubMed ID: 22210315	2012
Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations. Diabetes care\| PubMed ID: 22210575	2012
A genome-wide association search for type 2 diabetes genes in African Americans. PloS one\| PubMed ID: 22238593	2012
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nature genetics\| PubMed ID: 22286214	2012
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. Nature genetics\| PubMed ID: 22327514	2012
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature\| PubMed ID: 22343897	2012
Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition. The Journal of infectious diseases\| PubMed ID: 22362864	2012
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. PloS one\| PubMed ID: 22403646	2012
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nature genetics\| PubMed ID: 22406640	2012
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes\| PubMed ID: 22415877	2012
Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population. Obesity (Silver Spring, Md.)\| PubMed ID: 22447289	2012
High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Molecular genetics and metabolism\| PubMed ID: 22463805	2012
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS genetics\| PubMed ID: 22479202	2012
A genome-wide association meta-analysis identifies new childhood obesity loci. Nature genetics\| PubMed ID: 22484627	2012
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. Best practice & research. Clinical endocrinology & metabolism\| PubMed ID: 22498247	2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature genetics\| PubMed ID: 22581228	2012
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 22592557	2012
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. Human molecular genetics\| PubMed ID: 22595969	2012
Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. PloS one\| PubMed ID: 22606236	2012
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PloS one\| PubMed ID: 22685556	2012
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS genetics\| PubMed ID: 22693455	2012
Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes\| PubMed ID: 22698912	2012
Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene. PloS one\| PubMed ID: 22701567	2012
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic acids research\| PubMed ID: 22730288	2012
Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS one\| PubMed ID: 22768283	2012
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature genetics\| PubMed ID: 22885922	2012
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature genetics\| PubMed ID: 22885924	2012
Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530. Diabetes\| PubMed ID: 22923658	2012
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature genetics\| PubMed ID: 23202124	2012
Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. PloS one\| PubMed ID: 23209618	2012
Seventy-five genetic loci influencing the human red blood cell. Nature\| PubMed ID: 23222517	2012
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature genetics\| PubMed ID: 23263486	2012
Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23264395	2012