Dobromir Dobrev

Institute of Pharmacology, University of Duisburg-Essen

Affiliated withUniversity of Duisburg-Essen University of Heidelberg

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 29	2013

Other Publications

Article	Year
Problem-based learning: a new pathway to competence? Trends in pharmacological sciences\| PubMed ID: 11931987	2002
Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovascular research\| PubMed ID: 12062344	2002
What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy". Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 12107636	2002
Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 12134978	2002
Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum. European journal of pharmacology\| PubMed ID: 12586205	2003
Cardiac sympathetic innervation and control of potassium channel function. Journal of molecular and cellular cardiology\| PubMed ID: 12606253	2003
Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic research in cardiology\| PubMed ID: 12883831	2003
Transcription factors for ion channels: active or passive players in cardiac remodeling? Cardiovascular research\| PubMed ID: 14613850	2003
Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation. Journal of molecular and cellular cardiology\| PubMed ID: 14654366	2003
Mechanisms of beta-adrenergic receptor-mediated venodilation in humans. Clinical pharmacology and therapeutics\| PubMed ID: 14749691	2004
Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation? European heart journal\| PubMed ID: 15231365	2004
Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation\| PubMed ID: 15477405	2004
An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 15599709	2004
Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo? Pacing and clinical electrophysiology : PACE\| PubMed ID: 15613126	2004
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation\| PubMed ID: 15851612	2005
Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing. Gene expression\| PubMed ID: 15892449	2005
Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. Basic & clinical pharmacology & toxicology\| PubMed ID: 15910408	2005
Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 15942582	2005
Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation\| PubMed ID: 16027256	2005
Electrical remodeling in atrial fibrillation. Herz\| PubMed ID: 16738832	2006
Do genetics help to better understand the underlying mechanisms of atrial fibrillation? European heart journal\| PubMed ID: 16760202	2006
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochemical and biophysical research communications\| PubMed ID: 16774736	2006
Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation\| PubMed ID: 16894034	2006
5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation? Journal of molecular and cellular cardiology\| PubMed ID: 17064728	2007
Novel anti-arrhythmic agents for the treatment of atrial fibrillation. Current opinion in pharmacology\| PubMed ID: 17303472	2007
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation. Cardiovascular research\| PubMed ID: 17362895	2007
Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 17560599	2007
Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 17593353	2007
Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 17932654	2007
Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis? Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 17999053	2007
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovascular research\| PubMed ID: 18006448	2008
Bootstrapped two-electrode biosignal amplifier. Medical & biological engineering & computing\| PubMed ID: 18266016	2008
New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing\| PubMed ID: 18330686	2008
Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis. Cardiovascular research\| PubMed ID: 18390898	2008
Digital lock-in techniques for adaptive power-line interference extraction. Physiological measurement\| PubMed ID: 18560061	2008
Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 18598963	2008
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovascular research\| PubMed ID: 18689792	2008
Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circulation research\| PubMed ID: 18723446	2008
Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. Journal of cardiovascular pharmacology\| PubMed ID: 18791467	2008
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovascular research\| PubMed ID: 18826964	2009
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. Journal of molecular and cellular cardiology\| PubMed ID: 19100271	2009
The German Competence Network on Atrial Fibrillation (AFNET). Herz\| PubMed ID: 19137244	2008
Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. European heart journal\| PubMed ID: 19269986	2009
Ion channel portrait of the human sinus node: useful for a better understanding of sinus node function and dysfunction in humans? Circulation\| PubMed ID: 19332478	2009
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. The Journal of clinical investigation\| PubMed ID: 19603549	2009
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 19760273	2010
Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 19784635	2010
Atrial remodeling and atrial fibrillation: mechanisms and implications. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 19808395	2008
Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 19808399	2008
Animal models for atrial fibrillation: clinical insights and scientific opportunities. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 19875395	2010
Stroke prevention versus bleeding risk of vitamin-K antagonists: a double-edged sword in patients with atrial fibrillation who require surgery. Cardiovascular therapeutics\| PubMed ID: 19903184	2009
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. The Journal of clinical investigation\| PubMed ID: 20071777	2010
New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet\| PubMed ID: 20334907	2010
Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation. British journal of pharmacology\| PubMed ID: 20388187	2010
Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 20657029	2010
Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 20660541	2010
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends in cardiovascular medicine\| PubMed ID: 20685575	2010
The impact of rapid atrial pacing on ADMA and endothelial NOS. International journal of cardiology\| PubMed ID: 20926145	2012
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovascular research\| PubMed ID: 20943673	2011
Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods in enzymology\| PubMed ID: 21036255	2010
Vernakalant. Nature reviews. Drug discovery\| PubMed ID: 21119728	2010
Enhanced myofilament responsiveness upon Î²-adrenergic stimulation in post-infarct remodeled myocardium. Journal of molecular and cellular cardiology\| PubMed ID: 21156182	2011
Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation\| PubMed ID: 21200008	2011
New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications. Cardiovascular research\| PubMed ID: 21296897	2011
Phosphatase-1 inhibitor-1 in physiological and pathological Î²-adrenoceptor signalling. Cardiovascular research\| PubMed ID: 21354993	2011
Atrial-selective sodium channel block by dronedarone: sufficient to terminate atrial fibrillation? Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 21541758	2011
Prevention of atrial fibrillation complications with antiarrhythmic drugs: still an unmet need in clinical practice. Expert opinion on pharmacotherapy\| PubMed ID: 21548721	2011
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation\| PubMed ID: 21555709	2011
No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population. Clinical chemistry and laboratory medicine : CCLM / FESCC\| PubMed ID: 21574885	2011
Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovascular research\| PubMed ID: 21622683	2011
Oxidized CaMKII causes cardiac sinus node dysfunction in mice. The Journal of clinical investigation\| PubMed ID: 21785215	2011
Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rh... Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 21791573	2012
Recent advances in the molecular pathophysiology of atrial fibrillation. The Journal of clinical investigation\| PubMed ID: 21804195	2011
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation\| PubMed ID: 21859974	2011
Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circulation research\| PubMed ID: 21903936	2011
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation research\| PubMed ID: 21921263	2011
Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice. Circulation research\| PubMed ID: 22158709	2012
Proarrhythmic atrial calcium cycling in the diseased heart. Advances in experimental medicine and biology\| PubMed ID: 22453988	2012
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation\| PubMed ID: 22456474	2012
Novel molecular targets for atrial fibrillation therapy. Nature reviews. Drug discovery\| PubMed ID: 22460122	2012
The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities. European heart journal\| PubMed ID: 22507975	2012
Role of RyR2 phosphorylation at S2814 during heart failure progression. Circulation research\| PubMed ID: 22511749	2012
Calcium handling and atrial fibrillation. Wiener medizinische Wochenschrift (1946)\| PubMed ID: 22695810	2012
Systems approaches to post-operative atrial fibrillation - do they help us to better understand the ionic basis of the arrhythmogenic substrate? Journal of molecular and cellular cardiology\| PubMed ID: 22742961	2012
Is altered atrial microRNA-ome a critical contributor to the pathophysiology of atrial fibrillation? Basic research in cardiology\| PubMed ID: 22802051	2012
Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C. The Journal of biological chemistry\| PubMed ID: 22843729	2012
Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation\| PubMed ID: 22992321	2012
Voltage-gated Naâº channels: novel players in fibroblast-to-myofibroblast transition with a potential role in atrial arrhythmogenesis? The Journal of physiology\| PubMed ID: 23082023	2012
Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 23104921	2012
The biology of human pulmonary veins: does it help us to better understand AF pathophysiology in patients? Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 23237913	2013
New directions in antiarrhythmic drug therapy for atrial fibrillation. Future cardiology\| PubMed ID: 23259476	2013
Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic research in cardiology\| PubMed ID: 23429935	2013
MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation\| PubMed ID: 23459615	2013
Impaired Na(+)-dependent regulation of acetylcholine-activated inward-rectifier K(+) current modulates action potential rate dependence in patients with chronic atrial fibrillation. Journal of molecular and cellular cardiology\| PubMed ID: 23531443	2013
Pleiotropic actions of amiodarone: still puzzling after half a century. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 23568552	2013
Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. Journal of the American College of Cardiology\| PubMed ID: 23583240	2013
KCNQ1 autoantibodies: another way to regulate IKs. Cardiovascular research\| PubMed ID: 23615563	2013
Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update. Vascular health and risk management\| PubMed ID: 23637539	2013
Phosphodiesterase-2 is Upregulated in Human Failing Hearts and Blunts Î²-Adrenergic Responses in Cardiomyocytes. Journal of the American College of Cardiology\| PubMed ID: 23810893	2013