Korkut Uygun

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School

Affiliated withMassachusetts General Hospital, Harvard Medical School Shriners Hospital for Children

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2021

Other Publications

Article	Year
Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion. Transplantation direct\| PubMed ID: 29796416	2018
Oxygenated UW Solution Decreases ATP Decay and Improves Survival After Transplantation of DCD Liver Grafts. Transplantation\| PubMed ID: 30422952	2019
Advances in machine perfusion, organ preservation, and cryobiology: potential impact on vascularized composite allotransplantation. Current opinion in organ transplantation\| PubMed ID: 30080697	2018
Investigation of metabolic objectives in cultured hepatocytes. Biotechnology and bioengineering\| PubMed ID: 17058287	2007
A model for normothermic preservation of the rat liver. Tissue engineering\| PubMed ID: 17596120	2007
Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplantation proceedings\| PubMed ID: 18589093	2008
Tissue growth modeling in a wavy-walled bioreactor. Tissue engineering. Part A\| PubMed ID: 18847355	2009
Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation\| PubMed ID: 19155970	2009
High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology\| PubMed ID: 19303403	2009
Effects of burn injury on markers of hypermetabolism in rats. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 19898103	2009
Cell delivery: from cell transplantation to organ engineering. Cell transplantation\| PubMed ID: 20525441	2010
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature medicine\| PubMed ID: 20543851	2010
Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability. Transplantation proceedings\| PubMed ID: 20832525	2010
Optimization-based metabolic control analysis. Biotechnology progress\| PubMed ID: 20967921	2010
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21077107	2010
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21404258	2011
Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annual review of biomedical engineering\| PubMed ID: 21417722	2011
Subnormothermic Machine Perfusion at Both 20Â°C and 30Â°C Recovers Ischemic Rat Livers for Successful Transplantation. The Journal of surgical research\| PubMed ID: 21550058	2011
A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnology and bioengineering\| PubMed ID: 22006574	2012
A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PloS one\| PubMed ID: 22194843	2011
A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC research notes\| PubMed ID: 22731806	2012
Application of whole-organ tissue engineering in hepatology. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 22890112	2012
A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation. Transplantation research\| PubMed ID: 23369351	2012
Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PloS one\| PubMed ID: 23874947	2013
Strategies to rescue steatotic livers before transplantation in clinical and experimental studies. World journal of gastroenterology : WJG\| PubMed ID: 23922462	2013
Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PloS one\| PubMed ID: 23922793	2013
Perfusion defatting at subnormothermic temperatures in steatotic rat livers. Transplantation proceedings\| PubMed ID: 24182786	2013
Determination and extension of the limits to static cold storage using subnormothermic machine perfusion. The International journal of artificial organs\| PubMed ID: 24338652	2013
Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures. Journal of hepatology\| PubMed ID: 24560661	2014
Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites\| PubMed ID: 24957642	2012
Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nature medicine\| PubMed ID: 24973919	2014
Organomatics and organometrics: Novel platforms for long-term whole-organ culture. Technology\| PubMed ID: 25035864	2014
SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell medicine\| PubMed ID: 25431743	2013
Supercooling preservation and transplantation of the rat liver. Nature protocols\| PubMed ID: 25692985	2015
Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice. Nature protocols\| PubMed ID: 25719268	2015
Warm Ischemic Injury Is Reflected in the Release of Injury Markers during Cold Preservation of the Human Liver. PloS one\| PubMed ID: 25822248	2015
Machine perfusion enhances hepatocyte isolation yields from ischemic livers. Cryobiology\| PubMed ID: 26188080	2015
Metabolic profiling during ex vivo machine perfusion of the human liver. Scientific reports\| PubMed ID: 26935866	2016
Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nature chemical biology\| PubMed ID: 27723751	2016
Peritransplant Energy Changes and Their Correlation to Outcome After Human Liver Transplantation. Transplantation\| PubMed ID: 28230641	2017
Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 28240817	2017
Subzero organ preservation: the dawn of a new ice age? Current opinion in organ transplantation\| PubMed ID: 28266941	2017
The promise of organ and tissue preservation to transform medicine. Nature biotechnology\| PubMed ID: 28591112	2017
A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab on a chip\| PubMed ID: 29068447	2017
Metabolomic Modularity Analysis (MMA) to Quantify Human Liver Perfusion Dynamics. Metabolites\| PubMed ID: 29137180	2017
Improved Cuff Technique and Intraoperative Detection of Vascular Complications for Hind Limb Transplantation in Mice. Transplantation direct\| PubMed ID: 29464206	2018
Caspase Inhibition: Optimizing Grafts for Transplantation. Transplantation\| PubMed ID: 29757905	2018
Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. Technology\| PubMed ID: 29780857	2017
Contrast-Enhanced Ultrasound to Quantifyc Perfusion in a Machine-Perfused Pig Liver. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 30441057	2018
Bulk Droplet Vitrification: An Approach to Improve Large-Scale Hepatocyte Cryopreservation Outcome. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 30514081	2019
Specific Patterns of Postoperative Temperature Elevations Predict Blood Infection in Pediatric Burn Patients. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 30668737	2019
Increasing Donor Liver Utilization Through Machine Perfusion. Hepatology (Baltimore, Md.)\| PubMed ID: 30681724	2019
Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis. Journal of clinical and translational research\| PubMed ID: 30761355	2018
Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 30938927	2019
A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion. Technology\| PubMed ID: 31106253	2017
Systems engineering the organ preservation process for transplantation. Current opinion in biotechnology\| PubMed ID: 31280087	2019
The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artificial organs\| PubMed ID: 31368159	2020
Exploring donor demographics effects on hepatocyte yield and viability: Results of whole human liver isolation from one center. Technology\| PubMed ID: 31414037	2019
Leveraging the zebrafish to model organ transplantation. Current opinion in organ transplantation\| PubMed ID: 31483338	2019
Supercooling extends preservation time of human livers. Nature biotechnology\| PubMed ID: 31501557	2019
Effect of Ice Nucleation and Cryoprotectants during High Subzero-Preservation in Endothelialized Microchannels. ACS biomaterials science & engineering\| PubMed ID: 31544149	2018
Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion. Metabolites\| PubMed ID: 31652927	2019
Pumping new life into old ideas: Preservation and rehabilitation of the liver using ex situ machine perfusion. Artificial organs\| PubMed ID: 31691326	2020
Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PloS one\| PubMed ID: 31790444	2019
Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions. Journal of clinical medicine\| PubMed ID: 31963739	2020
Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PloS one\| PubMed ID: 31978172	2020
Cell release during perfusion reflects cold ischemic injury in rat livers. Scientific reports\| PubMed ID: 31980677	2020
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content. PloS one\| PubMed ID: 32396553	2020
Subzero non-frozen preservation of human livers in the supercooled state. Nature protocols\| PubMed ID: 32433625	2020
Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion. Journal of clinical medicine\| PubMed ID: 32549246	2020
Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost. Clinical transplantation\| PubMed ID: 32860634	2020
Multiorgan Metabolomics and Lipidomics Provide New Insights Into Fat Infiltration in the Liver, Muscle Wasting, and Liver-Muscle Crosstalk Following Burn Injury. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 32877506	2021
A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. Nature biomedical engineering\| PubMed ID: 33257853	2021
Evolving utilization of donation after circulatory death livers in liver transplantation: The day of DCD has come. Clinical transplantation\| PubMed ID: 33368701	2021
Liver donor age affects hepatocyte function through age-dependent changes in decellularized liver matrix. Biomaterials\| PubMed ID: 33524812	2021
In Vivo Activity of Genetically Modified Cells Preseeded in Rat Vascularized Composite Allografts. Transplantation proceedings\| PubMed ID: 33985799	2021
Thrombolytic Therapy During Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury. Frontiers in surgery\| PubMed ID: 34222314	2021
Twenty-four hour ex-vivo normothermic machine perfusion in rat livers. Technology\| PubMed ID: 34307768	2020
Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts. The Journal of surgical research\| PubMed ID: 34670191	2022
Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion. PloS one\| PubMed ID: 34705828	2021
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 34730028	2022
The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion. Scientific reports\| PubMed ID: 34848781	2021
CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 35062050	2022
Specific patterns of vital sign fluctuations predict infection and enable sepsis diagnosis in pediatric burn patients. PloS one\| PubMed ID: 35130306	2022
Modeling energy depletion in rat livers using Nash equilibrium metabolic pathway analysis. Scientific reports\| PubMed ID: 35241684	2022
Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion. Journal of reconstructive microsurgery\| PubMed ID: 35764315	2022
Partial freezing of rat livers extends preservation time by 5-fold. Nature communications\| PubMed ID: 35840553	2022
A Novel Digital Algorithm for Identifying Liver Steatosis Using Smartphone-Captured Images. Transplantation direct\| PubMed ID: 35935028	2022
Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates innate immune responses. Frontiers in immunology\| PubMed ID: 35958587	2022
Subnormothermic Ex Vivo Porcine Kidney Perfusion Improves Energy Metabolism: Analysis Using P Magnetic Resonance Spectroscopic Imaging. Transplantation direct\| PubMed ID: 36176724	2022
Microvascular assessment of fascio-cutaneous flaps by ultrasound: A large animal study. Frontiers in physiology\| PubMed ID: 36589429	2022
Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol. PloS one\| PubMed ID: 36652460	2023
Continuous versus Pulsatile Flow in 24-Hour Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study. The Journal of surgical research\| PubMed ID: 36915006	2023
The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers. Frontiers in physics\| PubMed ID: 37151819	2022
Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction. Journal of clinical medicine\| PubMed ID: 37373707	2023
Response Regarding: Continuous Versus Pulsatile Flow in 24-h Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study. The Journal of surgical research\| PubMed ID: 37517972	2023
Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136006	2023
The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136031	2023
VCA supercooling in a swine partial hindlimb model. Scientific reports\| PubMed ID: 38824189	2024
Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery. Biosensors & bioelectronics\| PubMed ID: 38971037	2024
Sub-zero non-freezing of vascularized composite allografts in a rodent partial hindlimb model. Cryobiology\| PubMed ID: 39134131	2024
Supercooling preservation of vascularized composite allografts through CPA optimization, thermal tracking, and stepwise loading techniques. Scientific reports\| PubMed ID: 39333375	2024
Optimized partial freezing protocol enables 10-day storage of rat livers. Scientific reports\| PubMed ID: 39448774	2024
Enhanced VCA Storage: A Pilot Study Demonstrating Supercooling in Orthotopic Rodent Hindlimb Transplantation. Transplantation proceedings\| PubMed ID: 39490377	2024
UW supplementation with AP39 improves liver viability following static cold storage. Scientific reports\| PubMed ID: 39789174	2025
Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion. Annual review of biomedical engineering\| PubMed ID: 39874605	2025
Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers. Gene therapy\| PubMed ID: 40263629	2025
Subzero kidney preservation comes to scale. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41138969	2025