Evan Y. Snyder

Department of Pediatrics, University of California, San Diego School of Medicine

Affiliated withUniversity of California, San Diego School of Medicine Sanford Consortium for Regenerative Medicine Sanford Burnham Prebys Medical Discovery Institute

Research Area

Developmental Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2021

Other Publications

Article	Year
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11867737	2002
Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. Experimental neurology\| PubMed ID: 11922658	2002
Limitations in brain repair. Nature medicine\| PubMed ID: 12205449	2002
Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery\| PubMed ID: 12234415	2002
Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nature biotechnology\| PubMed ID: 12379867	2002
The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nature biotechnology\| PubMed ID: 12379868	2002
Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Experimental neurology\| PubMed ID: 12429210	2002
Neural stem cells for CNS repair: state of the art and future directions. Advances in experimental medicine and biology\| PubMed ID: 12614070	2002
Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis. Physiological genomics\| PubMed ID: 12923300	2003
Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer journal (Sudbury, Mass.)\| PubMed ID: 12952304	2003
Realistic prospects for stem cell therapeutics. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 14633792	2003
Constitutive EGFR signaling confers a motile phenotype to neural stem cells. Molecular and cellular neurosciences\| PubMed ID: 14697673	2003
Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells. Experimental neurology\| PubMed ID: 14980806	2004
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14981254	2004
Reality and immortality--neural stem cells for therapies. Nature biotechnology\| PubMed ID: 14990948	2004
Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. Journal of neuroscience research\| PubMed ID: 15048913	2004
Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli. The American journal of pathology\| PubMed ID: 15111308	2004
Stem cells: cross-talk and developmental programs. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 15293810	2004
Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord. The Journal of comparative neurology\| PubMed ID: 15514921	2004
Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Molecular and cellular neurosciences\| PubMed ID: 15519246	2004
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15608062	2004
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. Journal of neurotrauma\| PubMed ID: 15684646	2004
Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures. Cell transplantation\| PubMed ID: 15929553	2005
Expression profile of an operationally-defined neural stem cell clone. Experimental neurology\| PubMed ID: 15992799	2005
A role for stem cell biology in the physiological and pathological aspects of aging. Journal of the American Geriatrics Society\| PubMed ID: 16131354	2005
Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. Brain research\| PubMed ID: 16309635	2005
Gene therapy: can neural stem cells deliver? Nature reviews. Neuroscience\| PubMed ID: 16371952	2006
Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis. Neuroscience letters\| PubMed ID: 16388902	2006
Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16434473	2006
Beyond fraud--stem-cell research continues. The New England journal of medicine\| PubMed ID: 16436761	2006
Can science resolve the ethical impasse in stem cell research? Nature biotechnology\| PubMed ID: 16601717	2006
Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. The European journal of neuroscience\| PubMed ID: 16630059	2006
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16682647	2006
Neural stem cells as novel cancer therapeutic vehicles. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16697638	2006
Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Experimental neurology\| PubMed ID: 16714016	2006
Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but are not committed. Experimental neurology\| PubMed ID: 16714017	2006
Acute injury directs the migration, proliferation, and differentiation of solid organ stem cells: evidence from the effect of hypoxia-ischemia in the CNS on clonal "reporter" neural stem cel... Experimental neurology\| PubMed ID: 16737696	2006
Special issue: the intersection of stem/progenitor cell biology and hypoxic-ischemic cerebral injury/stroke. Experimental neurology\| PubMed ID: 16798271	2006
Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non-autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy. Journal of neurochemistry\| PubMed ID: 16805770	2006
Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology\| PubMed ID: 16839540	2006
Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16870729	2006
Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology. Nature methods\| PubMed ID: 16990812	2006
Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins. Stem cells (Dayton, Ohio)\| PubMed ID: 17071855	2006
The leading edge of stem cell therapeutics. Annual review of medicine\| PubMed ID: 17100553	2007
Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology\| PubMed ID: 17114629	2006
Exploring common ground in the stem cell ethical debate--a perspective for scientists: introduction to this special issue of stem cell reviews. Stem cell reviews\| PubMed ID: 17142867	2005
Isolation of amniotic stem cell lines with potential for therapy. Nature biotechnology\| PubMed ID: 17206138	2007
Immunomodulatory neural stem cells for brain tumour therapy. Expert opinion on biological therapy\| PubMed ID: 17223735	2006
Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice. Brain research\| PubMed ID: 17289003	2007
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nature medicine\| PubMed ID: 17351625	2007
Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells. Regenerative medicine\| PubMed ID: 17465758	2006
Large animal models are critical for rationally advancing regenerative therapies. Regenerative medicine\| PubMed ID: 17465832	2006
A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes. Stem cells (Dayton, Ohio)\| PubMed ID: 17556596	2007
Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17586681	2007
Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hearing research\| PubMed ID: 17659854	2007
Neural stem cell implantation extends life in Niemann-Pick C1 mice. Journal of applied genetics\| PubMed ID: 17666780	2007
Neural progenitor cell transplantation and imaging in a large animal model. Neuroscience research\| PubMed ID: 17897743	2007
Genetic modification of neural stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18253153	2008
Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge. Neurosurgical focus\| PubMed ID: 18341398	2008
Brain tumor stem cells and the tumor microenvironmen. Neurosurgical focus\| PubMed ID: 18341404	2008
Quo vadis brain repair? A long axonal journey in the adult CNS. Cell stem cell\| PubMed ID: 18371370	2007
Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease. Experimental neurology\| PubMed ID: 18394605	2008
Neural stem cell transplantation in mouse brain. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 18428671	2008
Inflammation as a matchmaker: revisiting cell fusion. Nature cell biology\| PubMed ID: 18454127	2008
Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida. Surgery\| PubMed ID: 18707035	2008
Preparation of autogenic human feeder cells for growth of human embryonic stem cells. Current protocols in stem cell biology\| PubMed ID: 18770638	2008
Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2. Experimental neurology\| PubMed ID: 19109951	2009
Neural precursor cell lines promote neurite branching. The International journal of neuroscience\| PubMed ID: 19116829	2009
Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. Journal of neuroscience research\| PubMed ID: 19125409	2009
Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19193855	2009
Neuroimaging as a basis for rational stem cell therapy. Pediatric neurology\| PubMed ID: 19218036	2009
The dynamics of long-term transgene expression in engrafted neural stem cells. The Journal of comparative neurology\| PubMed ID: 19399895	2009
Long-term multilayer adherent network (MAN) expansion, maintenance, and characterization, chemical and genetic manipulation, and transplantation of human fetal forebrain neural stem cells. Current protocols in stem cell biology\| PubMed ID: 19455542	2009
Maintaining and engineering neural stem cells for delivery of genetically encoded therapy to brain tumors. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19582432	2009
Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease. Stem cells (Dayton, Ohio)\| PubMed ID: 19591217	2009
Phosphoproteomic analysis of human embryonic stem cells. Cell stem cell\| PubMed ID: 19664994	2009
Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturation. Current protocols in stem cell biology\| PubMed ID: 19725014	2009
A safer stem cell: on guard against cancer. Nature medicine\| PubMed ID: 19734873	2009
Cross-talk between stem cells and the dysfunctional brain is facilitated by manipulating the niche: evidence from an adhesion molecule. Stem cells (Dayton, Ohio)\| PubMed ID: 19785036	2009
Important precautions when deriving patient-specific neural elements from pluripotent cells. Cytotherapy\| PubMed ID: 19903095	2009
The transcriptional network for mesenchymal transformation of brain tumours. Nature\| PubMed ID: 20032975	2010
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133595	2010
Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20147621	2010
Derivation of vasculature from embryonic stem cells. Current protocols in stem cell biology\| PubMed ID: 20200855	2010
Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer. The Journal of biological chemistry\| PubMed ID: 20404328	2010
Culture and manipulation of neural stem cells. Advances in experimental medicine and biology\| PubMed ID: 20455492	2010
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-ÎºB signaling. Neuron\| PubMed ID: 20920790	2010
Early acquisition of neural crest competence during hESCs neuralization. PloS one\| PubMed ID: 21085480	2010
Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption. Stem cell research & therapy\| PubMed ID: 21122109	2010
Self-renewal induced efficiently, safely, and effective therapeutically with one regulatable gene in a human somatic progenitor cell. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21378266	2011
Dorsomorphin promotes human embryonic stem cell self-renewal. Angewandte Chemie (International ed. in English)\| PubMed ID: 21384475	2011
Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury. Annals of neurology\| PubMed ID: 21387373	2011
The risk of putting something where it does not belong: mesenchymal stem cells produce masses in the brain. Experimental neurology\| PubMed ID: 21420402	2011
Overexpression of Basic Helix-Loop-Helix Transcription Factors Enhances Neuronal Differentiation of Fetal Human Neural Progenitor Cells in Various Ways. Stem cells and development\| PubMed ID: 21561385	2011
The intricate dance between repair and inflammation: introduction to special issue. Experimental neurology\| PubMed ID: 21596040	2011
DMSO-Free Programmed Cryopreservation of Fully Dissociated and Adherent Human Induced Pluripotent Stem Cells. Stem cells international\| PubMed ID: 21716669	2011
Modeling complex neuropsychiatric disorders with human induced pluripotent stem cells. Current opinion in pharmacology\| PubMed ID: 21723195	2011
Phosphoproteomic Analysis: An Emerging Role in Deciphering Cellular Signaling in Human Embryonic Stem Cells and Their Differentiated Derivatives. Stem cell reviews\| PubMed ID: 22009073	2011
Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. Journal of tissue engineering\| PubMed ID: 25383173	2014
Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies. Cell stem cell\| PubMed ID: 25575079	2015
Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem cells translational medicine\| PubMed ID: 25650438	2015
hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature. Stem cell reports\| PubMed ID: 26004631	2015
Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem cell reports\| PubMed ID: 27569059	2016
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28500272	2017
Finding a new purpose for old drugs. Science (New York, N.Y.)\| PubMed ID: 28860370	2017
Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder. Results and problems in cell differentiation\| PubMed ID: 30209664	2018
Stem Cell Composition of Umbilical Cord Blood Following Milking Compared with Delayed Clamping of the Cord Appears Better Suited for Promoting Hematopoiesis. The Journal of pediatrics\| PubMed ID: 31471115	2020
The Evolution of Stem Cells, Disease Modeling, and Drug Discovery for Neurological Disorders. Stem cells and development\| PubMed ID: 32024446	2020
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion. Translational psychiatry\| PubMed ID: 32094324	2020
Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells. Biochemical and biophysical research communications\| PubMed ID: 32115145	2020
A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury. Cell reports\| PubMed ID: 32402283	2020
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Current protocols in stem cell biology\| PubMed ID: 32640120	2020
Deriving Keratinocyte Progenitor Cells and Keratinocytes from Human-Induced Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 32744801	2020
"Reprogram Enablement" as an Assay for Identifying Early Oncogenic Pathways by Their Ability to Allow Neoplastic Cells to Reacquire an Epiblast State. Stem cell reports\| PubMed ID: 32795421	2020
Chemical mutagenesis of a GPCR ligand: Detoxifying "inflammo-attraction" to direct therapeutic stem cell migration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33219123	2020
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2. Molecular psychiatry\| PubMed ID: 33235333	2021
Strategies and Progress in CXCR4-Targeted Anti-Human Immunodeficiency Virus (HIV) Therapeutic Development. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 33624027	2021
Meningeal Multipotent Cells: A Hidden Target for CNS Repair? Neuromolecular medicine\| PubMed ID: 33893971	2021
A Tool for Accurate Stoichiometric Composition of Cryopreservative Media for Fetal and Induced Pluripotent Stem Cell-Derived Human Neural Stem Cells. Current protocols\| PubMed ID: 33950578	2021
The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Followin... Cell transplantation\| PubMed ID: 34053245	2021
Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34330827	2021
Protocol to optimize the Rice-Vannucci rat pup model of perinatal asphyxia to ensure predictable hypoxic-ischemic cerebral lesions. STAR protocols\| PubMed ID: 38852156	2024
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 39028694	2024
Exercise your graft - An important lesson for cell replacement therapy for Parkinson's disease. Experimental neurology\| PubMed ID: 39631719	2024