Murine Model of Wound Healing

Wound healing and repair are the most complex biological processes that occur in human life. After injury, multiple biological pathways become activated. ...

The Heart Research Institute

University of Sydney 

The aim of this study was to observe the direct physiological and biochemical cardiac effects in response to a newly identified putative component of the renin-angiotensin system, proangiotensin-12 (PA12); and investigate whether PA12 can serve as a substrate for Angiotensin II (AngII) generation.

Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics.

Le but de cette &eacute;tude &eacute;tait d&#39;observer les effets cardiaques directs physiologiques et biochimiques en r&eacute;ponse &agrave; un composant nouvellement identifi&eacute; putatif du syst&egrave;me r&eacute;nine-angiotensine, proangiotensin-12 (PA12) ; et &eacute;tudier si PA12 peut servir de substrat pour la production d&#39;angiotensine II (AngII).

Cardiaque chymase convertit rat proAngiotensin-12 (PA12) &agrave; l&#39;angiotensine II : effets de PA12 sur l&#39;h&eacute;modynamique cardiaque.

Lo scopo di questo studio era quello di osservare gli effetti diretti fisiologici e biochimici cardiache in risposta a un componente putativo recentemente identificato del sistema renina-angiotensina, proangiotensin-12 (PA12); e indagare se PA12 pu&ograve; servire come substrato per la generazione di angiotensina II (AngII).

Hamish C. G Prosser

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