Gianrico Farrugia

Enteric Neuroscience Program, Mayo Clinic

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 18	2013
Publication title Cited by 7	2018

Other Publications

Article	Year
Sodium current in human jejunal circular smooth muscle cells. Gastroenterology\| PubMed ID: 11781292	2002
Paraneoplastic dysmotility: loss of interstitial cells of Cajal. The American journal of gastroenterology\| PubMed ID: 12135044	2002
alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation. American journal of physiology. Cell physiology\| PubMed ID: 12176756	2002
The Kv2.2 alpha subunit contributes to delayed rectifier K(+) currents in myocytes from rabbit corpus cavernosum. Journal of andrology\| PubMed ID: 12399537	2002
Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. The Journal of biological chemistry\| PubMed ID: 12429735	2003
Cytoskeletal modulation of sodium current in human jejunal circular smooth muscle cells. American journal of physiology. Cell physiology\| PubMed ID: 12475760	2003
Chronic intestinal pseudoobstruction associated with altered interstitial cells of cajal networks. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 12658043	2003
Cholinergic denervation in diverticular disease. Lancet\| PubMed ID: 12801731	2003
A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12832617	2003
Sodium current in human intestinal interstitial cells of Cajal. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 12893628	2003
Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal. Current opinion in pharmacology\| PubMed ID: 14644008	2003
Heme: a determinant of life and death in renal tubular epithelial cells. American journal of physiology. Renal physiology\| PubMed ID: 14707007	2004
The role of carbon monoxide in the gastrointestinal tract. The Journal of physiology\| PubMed ID: 14766943	2004
Nitric oxide in gastrointestinal health and disease. Gastroenterology\| PubMed ID: 14988844	2004
Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15319183	2005
Meal-induced dysphagia and otalgia secondary to a pyriform sinus fistula. Digestive diseases and sciences\| PubMed ID: 15481338	2004
Intercellular coupling of interstitial cells of cajal in the digestive tract. International review of cytology\| PubMed ID: 15598471	2005
Effect of mibefradil on sodium and calcium currents. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15790762	2005
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16166345	2006
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16269521	2006
Deciphering the molecular basis for the pacemaker signal. Gastroenterology\| PubMed ID: 16285975	2005
Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy. The American journal of gastroenterology\| PubMed ID: 16771953	2006
Serotonergic modulation of murine fundic tone. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16873894	2006
Ca2+ handling in human interstitial cells of Cajal. Gastroenterology\| PubMed ID: 17484898	2007
Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 17510199	2007
Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studies. Nature clinical practice. Gastroenterology & hepatology\| PubMed ID: 17541447	2007
Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology\| PubMed ID: 17854596	2007
Determination of gastric emptying in nonobese diabetic mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 17884976	2007
Evolving concepts in the cellular control of gastrointestinal motility: neurogastroenterology and enteric sciences. Gastroenterology clinics of North America\| PubMed ID: 17950435	2007
Evaluation of endoscopic approaches for deep gastric-muscle-wall biopsies: what works? Gastrointestinal endoscopy\| PubMed ID: 18028922	2008
Endoscopic "no hole" full-thickness biopsy of the stomach to detect myenteric ganglia. Gastrointestinal endoscopy\| PubMed ID: 18262183	2008
A mutation in telethonin alters Nav1.5 function. The Journal of biological chemistry\| PubMed ID: 18408010	2008
Enteric autoantibodies and gut motility disorders. Gastroenterology clinics of North America\| PubMed ID: 18499027	2008
Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. Journal of neurochemistry\| PubMed ID: 18513201	2008
Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis. BMC gastroenterology\| PubMed ID: 18513423	2008
Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18591664	2008
Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. Gastroenterology\| PubMed ID: 18926825	2008
Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19056759	2009
Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19179622	2009
Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal. Histopathology\| PubMed ID: 19236504	2009
Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta neuropathologica\| PubMed ID: 19360428	2009
Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19372102	2009
The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes. Journal of cellular and molecular medicine\| PubMed ID: 19413888	2009
Neural autoantibody profile of primary achalasia. Digestive diseases and sciences\| PubMed ID: 19499338	2010
Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. The Journal of biological chemistry\| PubMed ID: 19531484	2009
Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxidants & redox signaling\| PubMed ID: 19769466	2010
Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science. Gastroenterology\| PubMed ID: 19778538	2009
The Mayo Dysphagia Questionnaire-30: documentation of reliability and validity of a tool for interventional trials in adults with esophageal disease. Dysphagia\| PubMed ID: 19856027	2010
CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology\| PubMed ID: 20178793	2010
T-type Ca(2+) channel modulation by otilonium bromide. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20203058	2010
Carbon monoxide reverses diabetic gastroparesis in NOD mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20378827	2010
Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT(2B) knockout mice with altered interstitial cells of Cajal networks. Biophysical journal\| PubMed ID: 20441740	2010
Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. The Journal of physiology\| PubMed ID: 20581042	2010
The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut\| PubMed ID: 20581236	2010
Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. The American journal of gastroenterology\| PubMed ID: 20588262	2010
Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology\| PubMed ID: 20621681	2010
Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years. Gut\| PubMed ID: 20871131	2010
Epidemiology, mechanisms, and management of diabetic gastroparesis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 20951838	2011
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology\| PubMed ID: 20965184	2011
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. The Journal of physiology\| PubMed ID: 21041530	2010
Esophageal papillomas and skin abnormalities. Focal dermal hypoplasia (Goltz syndrome) manifesting with esophageal papillomatosis. Gastroenterology\| PubMed ID: 21272558	2011
Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology\| PubMed ID: 21300066	2011
Altered expression of Ano1 variants in human diabetic gastroparesis. The Journal of biological chemistry\| PubMed ID: 21349842	2011
Gastrointestinal neuromuscular pathology in chronic constipation. Best practice & research. Clinical gastroenterology\| PubMed ID: 21382578	2011
Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21393430	2011
Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 21397732	2011
Bloating in gastroparesis: severity, impact, and associated factors. The American journal of gastroenterology\| PubMed ID: 21483459	2011
Reply. Gastroenterology\| PubMed ID: 21540031	2011
Hydrogen sulfide modulates contractile function in rat jejunum. The Journal of surgical research\| PubMed ID: 21571312	2012
Loss of NRF2 impairs gastric nitrergic stimulation and function. Free radical biology & medicine\| PubMed ID: 21605664	2011
Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology\| PubMed ID: 21684286	2011
Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives. Frontiers in physiology\| PubMed ID: 21772822	2011
A stochastic multi-scale model of electrical function in normal and depleted ICC networks. IEEE transactions on bio-medical engineering\| PubMed ID: 21843981	2011
Similarities and differences between diabetic and idiopathic gastroparesis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 21871247	2011
Ultrastructural differences between diabetic and idiopathic gastroparesis. Journal of cellular and molecular medicine\| PubMed ID: 21914127	2012
Ano1 as a regulator of proliferation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21940901	2011
Quantification of gastrointestinal sodium channelopathy. Journal of theoretical biology\| PubMed ID: 21959314	2012
Inhaled carbon monoxide attenuates myocardial inflammatory cytokine expression in a rat model of cardiopulmonary bypass. The Journal of extra-corporeal technology\| PubMed ID: 22164452	2011
Targeting ion channels for the treatment of gastrointestinal motility disorders. Therapeutic advances in gastroenterology\| PubMed ID: 22282704	2012
Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action. Circulation\| PubMed ID: 22565935	2012
The places to be for neurogastroenterologists. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society\| PubMed ID: 22583599	2012
Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology\| PubMed ID: 22643349	2012
Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity. Channels (Austin, Tex.)\| PubMed ID: 22874086	2012
Toward biphasic computed tomography (CT) enteric contrast: material classification of luminal bismuth and mural iodine in a small-bowel phantom using dual-energy CT. Journal of computer assisted tomography\| PubMed ID: 22992606	2012
Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1. Biochemical and biophysical research communications\| PubMed ID: 22995309	2012
Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells. Channels (Austin, Tex.)\| PubMed ID: 23018927	2012
Endoscopic full-thickness biopsy of the gastric wall with defect closure by using an endoscopic suturing device: survival porcine study. Gastrointestinal endoscopy\| PubMed ID: 23078926	2012
Age sensitizes the kidney to heme protein-induced acute kidney injury. American journal of physiology. Renal physiology\| PubMed ID: 23195679	2013
Intractable nausea and vomiting from autoantibodies against a brain water channel. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 23211959	2013
Kit Signaling Is Required for Development of Coordinated Motility Patterns in Zebrafish Gastrointestinal Tract. Zebrafish\| PubMed ID: 23297728	2013
Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice. Gastroenterology\| PubMed ID: 23380084	2013
Cholecystectomy and Clinical Presentations of Gastroparesis. Digestive diseases and sciences\| PubMed ID: 23456496	2013
Introducing our Associates. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society\| PubMed ID: 23480275	2013