causal-relationship-between-ischemic-stroke-vascular-dementia

Causal Relationship Between Ischemic Stroke and Vascular Dementia: A Mendelian Randomization Study

Ischemic stroke (IS) is a major cause of disability and mortality worldwide, and vascular dementia (VaD) is a common dementia subtype associated with ...

Baoding Second Hospital

We report on the synthesis of TiO2 nanotube (NT) powders using anodic oxidation and ultrasonication. Compared to free-standing NT array films, the powder-type NTs can be easily fabricated in a cost-effective way. Particularly, without the substrate effect arising from underlying Ti metals, highly crystallized NT powders with intact tube structures and pure anatase phase can be obtained using high-temperature heat treatment. The application of NTs with different crystallinity for the photocatalytic decomposition of methylene blue (MB) was then demonstrated. The results showed that with increasing annealing temperature, the photocatalytic decomposition rate was gradually enhanced, and the NT powder electrode annealed at 650°C showed the highest photoactivity. Compared to typical NTs annealed at 450°C, the rate constant increased by 2.7-fold, although the surface area was 21% lower. These findings indicate that the better photocatalytic activity was due to the significantly improved crystallinity of anatase anodic NTs in powder form, resulting in a low density of crystalline defects. This simple and efficient approach is applicable for scaled-up water purification and other light utilization applications. 

Anatase TiO2 nanotube powder film with high crystallinity for enhanced photocatalytic performance.

The abnormal self-assembly of the amyloid-&beta; peptide into toxic &beta;-rich aggregates can cause Alzheimer&rsquo;s disease. Recently, it has been shown that small gold nanoparticles (AuNPs) inhibit A&beta; aggregation and fibrillation by slowing down the nucleation process in experimental studies. However, the effects of AuNPs on A&beta; oligomeric structures are still unclear. In this study, we investigate the conformation of A&beta;(16-22) tetramers/octamers in the absence and presence of AuNPs using extensive all-atom molecular-dynamics simulations in explicit solvent. Our studies demonstrate that the addition of AuNPs into A&beta;(16-22) solution prevents &beta;-sheet formation, and the inhibition depends on the concentration of A&beta;(16-22) peptides. A detailed analysis of the A&beta;(16-22)/A&beta;(16-22)/water/AuNPs interactions reveals that AuNPs inhibit the &beta;-sheet formation resulting from the same physical forces: hydrophobic interactions. Overall, our computational study provides evidence that AuNPs are likely to inhibit A&beta;(16-22) and full-length A&beta; fibrillation. Thus, this work provides theoretical insights into the development of inorganic nanoparticles as drug candidates for treatment of AD.

Exploring the Mechanism of Inhibition of Au Nanoparticles on the Aggregation of Amyloid-β(16-22) Peptides at the Atom Level by All-Atom Molecular Dynamics.

Article	Year
Anatase TiO2 nanotube powder film with high crystallinity for enhanced photocatalytic performance. Nanoscale research letters\| PubMed ID: 25852405	2015
Exploring the Mechanism of Inhibition of Au Nanoparticles on the Aggregation of Amyloid-β(16-22) Peptides at the Atom Level by All-Atom Molecular Dynamics. International journal of molecular sciences\| PubMed ID: 29925792	2018

Yongsheng Liu

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