the-mir-21-5p-cell-adhesion-molecule-1-axis-non-small-cell-lung

The miR-21-5p-Cell Adhesion Molecule 1 Axis in Non-Small Cell Lung Cancer Progression and Prognosis

Evidence indicates that miR-21-5p is an important molecular regulator in non-small cell lung cancer (NSCLC). Cell adhesion molecule 1 (CADM1) is a ...

Sichuan University

In this paper, a multi-parameter integrated detection photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) is proposed for its application in detecting temperature, magnetic field, and refractive index. The air holes on both sides of the fiber core were coated with gold film and introduced to the temperature-sensitive medium (PDMS) and magnetic fluid (MF), detecting temperature and magnetic field, respectively. The graphene layer is also presented on the gold film of the D-type side polished surface to improve the sensor sensitivity. The sensor's critical parameters' influence on its performance is investigated using a mode solver based on the finite element method (FEM). Simulation results show when the samples refractive index (RI) detection is a range of 1.36~1.43, magnetic field detection is a range of 20~550 Oe, and the temperature detection is a range of 5~55 °C; the maximum sensor's sensitivity obtains 76,000 nm/RIU, magnetic field intensity sensitivity produces 164.06 pm/Oe, and temperature sensitivity obtains -5001.31 pm/°C.

An Integrated Detection Based on a Multi-Parameter Plasmonic Optical Fiber Sensor.

This paper presents a graphene-Au coated photonic crystal fiber (PCF) sensor in the visible regime. Designing a side-polish D-shaped plane over the PCF's defect of the periodic air holes can effectively enhance the evanescent field. Graphene on gold can enhance the sensor's sensitivity because it can stably adsorb biomolecules and increase the propagation constant of the surface plasmon polariton (SPP). Using the finite element method (FEM), we demonstrated that the sensing performance is greatly improved by optimizing the PCF's geometric structural parameter. The proposed PCF sensor exhibited high performance with a maximum wavelength sensitivity of 4200 nm/RIU, maximum amplitude sensitivity of 450 RIU, and refractive index resolution of 2.3 × 10 RIU in the sensing range 1.32-1.41. This research provides a potential application for the design a new generation of highly sensitive biosensors.

Highly Sensitive Graphene-Au Coated Plasmon Resonance PCF Sensor.

Herein, we propose a tunable plasmonic sensor with Fano resonators in an inverted U-shaped resonator. By manipulating the sharp asymmetric Fano resonance peaks, a high-sensitivity refractive index sensor can be realized. Using the multimode interference coupled-mode theory and the finite element method, we numerically simulate the influences of geometrical parameters on the plasmonic sensor. Optimizing the structure parameters, we can achieve a high plasmonic sensor with the maximum sensitivity for 840 nm/RIUand figure of merit for 3.9 × 10. The research results provide a reliable theoretical basis for designing high sensitivity to the next generation plasmonic nanosensor.

High Sensitivity Plasmonic Sensor Based on Fano Resonance with Inverted U-Shaped Resonator.

The development of antibiotic-resistant microorganisms is a major global health concern. Recently, there has been an increasing interest in antimicrobial peptides as a therapeutic option. This study aimed to evaluate the triple-action (broad-spectrum antibacterial, anti-biofilm, and anti-quorum sensing activities) of melittin, a membrane-active peptide present in bee venom. The minimum inhibitory concentration and minimum bactericidal concentration of the melittin were determined using the microdilution method and agar plate counting. Growth curve analysis revealed that melittin showed a concentration-dependent antibacterial activity. Scanning electron microscope analysis revealed that melittin treatment altered the morphology. Confocal laser scanning microscope revealed that melittin increased the membrane permeability and intracellular ROS generation in bacteria, all of which contribute to bacterial cell death. In addition, the crystal violet (CV) assay was used to test the anti-biofilm activity. The CV assay demonstrated that melittin inhibited biofilm formation and eradicated mature biofilms. Biofilm formation mediated by quorum sensing (QS) plays a major role in this regard, so molecular docking and molecular dynamics analysis confirmed that melittin interacts with LasR receptors through hydrogen bonds, and further evaluates the anti-QS activity of melittin through the production of virulence factors (pyocyanin, elastase, and rhamnolipid), exopolysaccharides secretion, and bacterial motility, that may be the key to inhibiting the biofilm formation mechanism. The present findings highlight the promising role of melittin as a broad-spectrum antibacterial, anti-biofilm agent, and potential QS inhibitor, providing a new perspective and theoretical basis for the development of alternative antibiotics.

Discovery of Melittin as Triple-Action Agent: Broad-Spectrum Antibacterial, Anti-Biofilm, and Potential Anti-Quorum Sensing Activities.

To systematically evaluate the therapeutic effect of BaitouWeng Decoction in patients with ulcerative colitis (UC), evaluate its safety and effectiveness, and provide a reference for clinical medication.

Article	Year
An Integrated Detection Based on a Multi-Parameter Plasmonic Optical Fiber Sensor. Sensors (Basel, Switzerland)\| PubMed ID: 33530317	2021
Highly Sensitive Graphene-Au Coated Plasmon Resonance PCF Sensor. Sensors (Basel, Switzerland)\| PubMed ID: 33530437	2021
High Sensitivity Plasmonic Sensor Based on Fano Resonance with Inverted U-Shaped Resonator. Sensors (Basel, Switzerland)\| PubMed ID: 33562255	2021
Discovery of Melittin as Triple-Action Agent: Broad-Spectrum Antibacterial, Anti-Biofilm, and Potential Anti-Quorum Sensing Activities. Molecules (Basel, Switzerland)\| PubMed ID: 38338303	2024
Efficacy and safety of BaitouWeng decoction for ulcerative colitis: A meta-analysis of randomized and controlled trials. Medicine\| PubMed ID: 38968514	2024

Hongyan Yang

Biography

JoVE Journal Publications

Other Publications