direct-imaging-er-calcium-with-targeted-esterase-induced-dye-loading

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

Visualization of calcium dynamics is important to understand the role of calcium in cell physiology. To examine calcium dynamics, synthetic fluorescent ...

University of Wuerzburg

Neurodegenerative disease affects tens of millions of people, worldwide, and comes at a cost to the public of billions of dollars. Stem cell therapy, in recent years, has generated a lot of enthusiasm as a novel treatment for neurodegenerative disease. In particular, Parkinson's disease has been identified as the ideal neurodegenerative disease to be treated using stem cells. Despite years of setbacks, recent experimental results have renewed optimism in the validity of stem cell therapy for the treatment of Parkinson's disease. In this review, we discuss advances in our understanding of the embryonic development of the dopamine system and the importance of these discoveries in the continued efforts towards stem cell therapy for Parkinson's disease.

From stem cells to dopamine neurons: developmental biology meets neurodegeneration.

Maladie neurod&eacute;g&eacute;n&eacute;rative touche des dizaines de millions de personnes, partout dans le monde et vient &agrave; un prix du public de milliards de dollars. Th&eacute;rapie de cellules souches, ces derni&egrave;res ann&eacute;es, a suscit&eacute; beaucoup d&#39;enthousiasme comme un nouveau traitement pour les maladies neuro-d&eacute;g&eacute;n&eacute;ratives. En particulier, la maladie de Parkinson a &eacute;t&eacute; identifi&eacute;e comme la maladie neurod&eacute;g&eacute;n&eacute;rative id&eacute;al &agrave; traiter &agrave; l&#39;aide de cellules souches. Malgr&eacute; des ann&eacute;es de d&eacute;boires, les r&eacute;cents r&eacute;sultats exp&eacute;rimentaux ont renouvel&eacute; optimisme dans la validit&eacute; de la th&eacute;rapie de cellules souches pour le traitement de la maladie de Parkinson. Dans cette revue, nous discutons des avances dans nos connaissances sur le d&eacute;veloppement embryonnaire du syst&egrave;me de la dopamine et l&#39;importance de ces d&eacute;couvertes dans les efforts continus vers la th&eacute;rapie de cellules souches pour la maladie de Parkinson.

Partir de cellules souches de neurones dopaminergiques : biologie du d&eacute;veloppement r&eacute;unit la neurod&eacute;g&eacute;n&eacute;rescence.

Malattia neurodegenerativa colpisce decine di milioni di persone, in tutto il mondo e ha un costo al pubblico di miliardi di dollari. Terapia della cellula formativa, negli ultimi anni, ha generato un sacco di entusiasmo come un nuovo trattamento per le malattie neurodegenerative. In particolare, morbo di Parkinson &egrave; stato identificato come la malattia neurodegenerativa ideale per essere trattati con cellule staminali. Nonostante anni di battute d&#39;arresto, recenti risultati sperimentali hanno rinnovato ottimismo nella validit&agrave; della terapia di cellule staminali per il trattamento del morbo di Parkinson. In questa recensione, discutiamo progressi nella nostra comprensione dello sviluppo embrionale del sistema della dopamina e l&#39;importanza di queste scoperte in continui sforzi verso la terapia della cellula formativa per il morbo di Parkinson.

Thomas Andreska

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JoVE Journal Publications

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