Lawrence Lum

Department of Cell Biology, UT Southwestern Medical Center

Affiliated withUT Southwestern Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2013

Other Publications

Article	Year
Immune Modulation in Cancer Patients After Adoptive Transfer of Anti-CD3/Anti-CD28-Costimulated T Cells-Phase I Clinical Trial. Journal of immunotherapy : official journal of the Society for Biological Therapy\| PubMed ID: 11685083	2001
The new stem cell biology. Transactions of the American Clinical and Climatological Association\| PubMed ID: 12053709	2002
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (New York, N.Y.)\| PubMed ID: 12663920	2003
Potential role for ADAM15 in pathological neovascularization in mice. Molecular and cellular biology\| PubMed ID: 12897135	2003
Phase I/II study of treatment of stage IV breast cancer with OKT3 x trastuzumab-armed activated T cells. Clinical breast cancer\| PubMed ID: 14499016	2003
Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells. Medicine and health, Rhode Island\| PubMed ID: 14582220	2003
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Molecular cell\| PubMed ID: 14636583	2003
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). The Journal of biological chemistry\| PubMed ID: 14638693	2004
Differentiation hotspots: the deterioration of hierarchy and stochasm. Blood cells, molecules & diseases\| PubMed ID: 14757410	2004
Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood cells, molecules & diseases\| PubMed ID: 14757418	2004
Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model. Cancer\| PubMed ID: 14983507	2004
How important is HER2/neu amplification and expression when selecting patients for HER2/neu-targeted therapies? Clinical breast cancer\| PubMed ID: 15140288	2004
The Hedgehog response network: sensors, switches, and routers. Science (New York, N.Y.)\| PubMed ID: 15205520	2004
Anti-CD3 x anti-HER2 bispecific antibody effectively redirects armed T cells to inhibit tumor development and growth in hormone-refractory prostate cancer-bearing severe combined immunodefic... Clinical prostate cancer\| PubMed ID: 15479495	2004
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15598741	2004
T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B cells and bypass complement-mediated rituximab resistance in vitro. Experimental hematology\| PubMed ID: 15781336	2005
Preclinical studies comparing different bispecific antibodies for redirecting T cell cytotoxicity to extracellular antigens on prostate carcinomas. Anticancer research\| PubMed ID: 15816517	2005
Virtual reality of stem cell transplantation to repair injured myocardium. Journal of cellular biochemistry\| PubMed ID: 15962306	2005
Retargeting T cells and immune effector cells with bispecific antibodies. Cancer chemotherapy and biological response modifiers\| PubMed ID: 16110617	2005
Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16397041	2006
The new face of bispecific antibodies: targeting cancer and much more. Experimental hematology\| PubMed ID: 16413384	2006
Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16428502	2006
Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16551871	2006
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell\| PubMed ID: 16630821	2006
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16882716	2006
Prevalence of off-target effects in Drosophila RNA interference screens. Nature\| PubMed ID: 16964239	2006
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature methods\| PubMed ID: 16990807	2006
Antibody targeting of stem cells to infarcted myocardium. Stem cells (Dayton, Ohio)\| PubMed ID: 17138964	2007
Tissue engineering and stem cell therapy for myocardial repair. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17569637	2007
Deconstructing the hedgehog pathway in development and disease. Science (New York, N.Y.)\| PubMed ID: 17916724	2007
Hedgehog signaling pathway. Science's STKE : signal transduction knowledge environment\| PubMed ID: 17925577	2007
Hedgehog signaling pathway in Drosophila. Science's STKE : signal transduction knowledge environment\| PubMed ID: 17925578	2007
Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18292296	2008
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18621708	2008
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology\| PubMed ID: 19125156	2009
Nonabsorbable corticosteroids use in the treatment of gastrointestinal graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 19285626	2009
Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorganic & medicinal chemistry letters\| PubMed ID: 19410457	2009
Chemical and biological studies of nakiterpiosin and nakiterpiosinone. Journal of the American Chemical Society\| PubMed ID: 20000429	2010
Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited. Cancer treatment reviews\| PubMed ID: 20381970	2010
Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart. Cardiovascular research\| PubMed ID: 20410290	2010
Cancer therapy with bispecific antibodies: Clinical experience. Current opinion in molecular therapeutics\| PubMed ID: 20521223	2010
Tankyrase is necessary for canonical Wnt signaling during kidney development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20549720	2010
Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: utility of cycle threshold values of qualitative real-time reverse ... Journal of clinical microbiology\| PubMed ID: 20844229	2010
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annual review of pharmacology and toxicology\| PubMed ID: 20887197	2011
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Science signaling\| PubMed ID: 21266715	2011
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (Cambridge, England)\| PubMed ID: 21350016	2011
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Journal of molecular and cellular cardiology\| PubMed ID: 21569778	2011
Induction of specific cellular and humoral responses against renal cell carcinoma after combination therapy with cryoablation and granulocyte-macrophage colony stimulating factor: a pilot st... Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 21577139	2011
In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 21713642	2011
Activated T cells from umbilical cord blood armed with anti-CD3 Ã— anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal allogeneic reactivity: a str... Transfusion\| PubMed ID: 21745212	2012
Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21808024	2012
A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 21971587	2012
Targeting T cells with bispecific antibodies for cancer therapy. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy\| PubMed ID: 22050339	2011
Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-Î²1 activity. Cancer immunology, immunotherapy : CII\| PubMed ID: 22057676	2012
The immunological contribution of NF-ÎºB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent. Biochimica et biophysica acta\| PubMed ID: 22155217	2012
Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II t... Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 22193771	2012
Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3 Ã— anti-CMV bispecific antibody. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 22313635	2012
Melphalan 180 mg/m2 can be safely administered as conditioning regimen before an autologous stem cell transplantation (ASCT) in multiple myeloma patients with creatinine clearance 60 mL/min/... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 22453252	2012
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental biology\| PubMed ID: 22546689	2012
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. The Journal of biological chemistry\| PubMed ID: 22593577	2012
Anti-CD3â€‰Ã—â€‰anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets. Pediatric blood & cancer\| PubMed ID: 22707078	2012
Anti-thymocyte globulin (thymoglobulin), tacrolimus, and sirolimus as acute graft-versus-host disease prophylaxis for unrelated hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 22710143	2012
Generation and immunologic functions of Th17 cells in malignant gliomas. Cancer immunology, immunotherapy : CII\| PubMed ID: 22752645	2012
Phase I trial of bortezomib during maintenance phase after high dose melphalan and autologous stem cell transplantation in patients with multiple myeloma. Journal of chemotherapy (Florence, Italy)\| PubMed ID: 22759762	2012
A phase I dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal rena... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 22892551	2013
Cell biology. The unusual case of Porcupine. Science (New York, N.Y.)\| PubMed ID: 22923569	2012
Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PloS one\| PubMed ID: 23185240	2012
The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids. Synlett : accounts and rapid communications in synthetic organic chemistry\| PubMed ID: 23226922	2012
Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway. Journal of translational medicine\| PubMed ID: 23394575	2013
Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies. BMC cancer\| PubMed ID: 23433400	2013
The development of highly potent inhibitors for porcupine. Journal of medicinal chemistry\| PubMed ID: 23477365	2013
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23479679	2013
Development and prospects for bispecific antibody-based therapeutics in cancer and other applications. Expert opinion on drug discovery\| PubMed ID: 23506181	2008
Signaling: Making a leaner Hedgehog. Nature chemical biology\| PubMed ID: 23508185	2013
CD20-Targeted T Cells after Stem Cell Transplantation for High Risk and Refractory Non-Hodgkin's Lymphoma. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 23529012	2013
Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 23591714	2013