Lali K. Medina-Kauwe

Lali K. Medina-Kauwe

Department of Biomedical Sciences, Cedars-Sinai Medical Center

Affiliated withCedars-Sinai Medical CenterUniversity of California, Los Angeles

Research Area

Biography

Dr. Lali Medina-Kauwe received her Ph.D. in Molecular Biology from UCLA in 1995 and used her skills in molecular engineering to create the first modified recombinant adenoviral capsid protein as a nonviral gene and drug delivery agent. She has since demonstrated that this agent can deliver imaging and therapeutic cargo to tumors in a missile-like targeted fashion by mimicking an essential ligand internalized by cancer cells; but, like a Trojan Horse, releases tumoricidal attack once past the cell barrier. Her technologies have led to several issued and pending patents related to nanobiologic targeting. In 2014, she co-founded Eos Biosciences, a spin-off company that has licensed her technologies for clinical development, while she continues to serve as Scientific Advisor to Eos.

Dr. Medina-Kauwe joined the Cedars-Sinai research faculty in 2003 and has remained continuously funded by the NIH/NCI as well as receiving grant support from the Department of Defense, Komen Foundation, Avon Foundation, and the American Cancer Society. She has served as a scientific reviewer for nearly three-dozen NIH study section panel meetings since 2006, as well as numerous grant review panels for the Department of Defense, and international foundations. She has been an invited conference speaker for the American Chemical Society, the American Society of Gene and Cell Therapy, Cold Spring Harbor Vector Targeting Strategies, and International Congress of Biochemistry and Molecular Biology; and at other institutions, including University of Washington, Emory University, U Penn, University of Wisconsin - Madison, UCLA, USC School of Pharmaceutical Sciences, UC Fullerton, and Oregon Health Sciences University.

In 2013, Dr. Medina-Kauwe accepted an appointment as Co-Director of the Ph.D. program in Biomedical Sciences and Translational Medicine at Cedars-Sinai Medical Center.

JoVE Journal Publications

ArticleTotal : 1
Year
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Publication title

Cited by 1

2013

Other Publications

Article
Year
Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells.

Vitamins and hormones| PubMed ID: 12481543

2002
Endocytosis of adenovirus and adenovirus capsid proteins.

Advanced drug delivery reviews| PubMed ID: 14597142

2003
Modulation of secretory functions in epithelia by adenovirus capsid proteins.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 14636719

2003
2006
2007
Corroles that bind with high affinity to both apo and holo transferrin.

Journal of inorganic biochemistry| PubMed ID: 18180041

2008
Tumor detection and elimination by a targeted gallium corrole.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19342490

2009
2011
2011
A Multimode Optical Imaging System for Preclinical Applications In Vivo: Technology Development, Multiscale Imaging, and Chemotherapy Assessment.

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging| PubMed ID: 21874388

2011
A mechanistic study of tumor-targeted corrole toxicity.

Molecular pharmaceutics| PubMed ID: 21981771

2011
2012
Chemotherapy targeting by DNA capture in viral protein particles.

Nanomedicine (London, England)| PubMed ID: 22385197

2012
2012
2012
Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 23041277

2012
2013
Investigating the photosensitizer-potential of targeted gallium corrole using multimode optical imaging.

Proceedings of SPIE--the International Society for Optical Engineering| PubMed ID: 26028799

2011
A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 26334483

2015
Multimode Optical Imaging for Translational Chemotherapy: In Vivo Tumor Detection and Delineation by Targeted Gallium Corroles.

Proceedings of SPIE--the International Society for Optical Engineering| PubMed ID: 26412924

2011
Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 29288681

2017
Large Field of View Scanning Fluorescence Lifetime Imaging System for Multimode Optical Imaging of Small Animals.

Proceedings of SPIE--the International Society for Optical Engineering| PubMed ID: 29386697

2008