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JoVE Journal Bioengineering
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
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Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Article DOI: 10.3791/50396 • 11:52 min • June 18th, 2013
June 18th, 2013 •
1, 1, 2,3
1Department of Biomedical Engineering, University of Southern California, 2Department of Biomedical Sciences, Cedars-Sinai Medical Center, 3Geffen School of Medicine, University of California, Los Angeles

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Summary
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This article details the procedures for optical imaging analysis of the tumor-targeted nanoparticle, HerDox. In particular, detailed use of the multimode imaging device for detecting tumor targeting and assessing tumor penetration is described here.

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Targeted Viral Protein Nanoparticles HER2+ Tumors HerDox Tumor-preferential Accumulation Tumor-growth Ablation Non-covalent Self-assembly Cell Penetration Protein Chemotherapy Agent Doxorubicin Small Nucleic Acid Linker Electrophilic Interactions Intercalation Interactions Oligomerization Interactions Stability In Blood Extended Storage Systemic Delivery Tumor-cell Death Adverse Effects Non-tumor Tissue Human Epidermal Growth Factor Receptor HER2 Elevation Fluorescence Intensity Imaging In Situ Confocal Analysis Spectral Analysis
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