Geert Bultynck

Department of Cellular and Molecular Medicine, KU Leuven

Affiliated withKU Leuven

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2013

Other Publications

Article	Year
The role of calmodulin for inositol 1,4,5-trisphosphate receptor function. Biochimica et biophysica acta\| PubMed ID: 12445455	2002
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. The EMBO journal\| PubMed ID: 14685260	2004
The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor. Journal of cell science\| PubMed ID: 14970260	2004
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction. The Biochemical journal\| PubMed ID: 15015936	2004
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. Molecular pharmacology\| PubMed ID: 15266018	2004
Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis. The Journal of biological chemistry\| PubMed ID: 15284241	2004
Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells. Molecular pharmacology\| PubMed ID: 15851651	2005
The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. The Journal of biological chemistry\| PubMed ID: 16380387	2006
The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis. Cell calcium\| PubMed ID: 16458354	2006
Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Molecular and cellular biology\| PubMed ID: 16738335	2006
Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate. The Journal of organic chemistry\| PubMed ID: 17585817	2007
The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2. Neuron\| PubMed ID: 17698014	2007
Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 17868032	2008
The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells. Investigative ophthalmology & visual science\| PubMed ID: 18614806	2008
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Molecular cell\| PubMed ID: 18657507	2008
Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Biochimica et biophysica acta\| PubMed ID: 19133301	2009
Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates. Organic & biomolecular chemistry\| PubMed ID: 19343261	2009
Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation. Cell calcium\| PubMed ID: 19482353	2009
Pannexins, distant relatives of the connexin family with specific cellular functions? BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 19644918	2009
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19706527	2009
Intracellular Ca2+ storage in health and disease: a dynamic equilibrium. Cell calcium\| PubMed ID: 20189643	2010
Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. The Journal of biological chemistry\| PubMed ID: 20375013	2010
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20634352	2010
Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum. Cellular signalling\| PubMed ID: 20688156	2011
Connexins: sensors and regulators of cell cycling. Biochimica et biophysica acta\| PubMed ID: 20801193	2011
STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling. Cell calcium\| PubMed ID: 20801505	2010
Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. Chemical communications (Cambridge, England)\| PubMed ID: 20938532	2011
The IP(3) receptor-mitochondria connection in apoptosis and autophagy. Biochimica et biophysica acta\| PubMed ID: 21146562	2011
Induction of CaÂ²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction. Blood\| PubMed ID: 21193695	2011
Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling. Communicative & integrative biology\| PubMed ID: 21331231	2010
IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging. Journal of aging research\| PubMed ID: 21423550	2011
Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harbor perspectives in biology\| PubMed ID: 21441595	2011
A dual role for Ca(2+) in autophagy regulation. Cell calcium\| PubMed ID: 21571367	2011
Calcium and connexin-based intercellular communication, a deadly catch? Cell calcium\| PubMed ID: 21621840	2011
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21654699	2011
Non-channel functions of connexins in cell growth and cell death. Biochimica et biophysica acta\| PubMed ID: 21718687	2012
STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function. Skeletal muscle\| PubMed ID: 21798093	2011
Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated. Autophagy\| PubMed ID: 22082873	2011
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. The Journal of biological chemistry\| PubMed ID: 22128171	2012
Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway. The Journal of biological chemistry\| PubMed ID: 22351781	2012
The contractile system as a negative regulator of the connexin 43 hemichannel. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 22375941	2012
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22665389	2012
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell communication and signaling : CCS\| PubMed ID: 22770472	2012
Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves. Brain research\| PubMed ID: 22789903	2012
Paracrine signaling through plasma membrane hemichannels. Biochimica et biophysica acta\| PubMed ID: 22796188	2013
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. PloS one\| PubMed ID: 22860057	2012
Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. The Journal of membrane biology\| PubMed ID: 22886208	2012
The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond. Cellular and molecular life sciences : CMLS\| PubMed ID: 22955373	2013
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor. Biochemical and biophysical research communications\| PubMed ID: 23058917	2012
Neuronal overexpression of IPâ‚ƒ receptor 2 is detrimental in mutant SOD1 mice. Biochemical and biophysical research communications\| PubMed ID: 23131553	2012
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic research in cardiology\| PubMed ID: 23184389	2013
Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors. Biochimica et biophysica acta\| PubMed ID: 23232185	2013
IP3, a small molecule with a powerful message. Biochimica et biophysica acta\| PubMed ID: 23291251	2013
Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions. Biochemical and biophysical research communications\| PubMed ID: 23376080	2013
Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress. Biochimica et biophysica acta\| PubMed ID: 23380704	2013
HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines. Haematologica\| PubMed ID: 23403318	2013
mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling. PloS one\| PubMed ID: 23565295	2013
Curcumin affects proprotein convertase activity: Elucidation of the molecular and subcellular mechanism. Biochimica et biophysica acta\| PubMed ID: 23583304	2013
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels. Neuropharmacology\| PubMed ID: 23664811	2013
Regulation of connexin- and pannexin-based channels by post-translational modifications. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 23718186	2013
Endothelial calcium dynamics; connexin channels and blood brain barrier function. Progress in neurobiology\| PubMed ID: 23851106	2013