Kam W. Leong

Kam W. Leong

Biomedical Engineering, Duke University

Affiliated withDuke UniversityColumbia UniversityColumbia College

Research Area

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JoVE Journal Publications

ArticleTotal : 3
Year
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
Publication title

Cited by 4

2009
2016
2024

Other Publications

Article
Year
Autologous fixed tumor vaccine: a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma.

Japanese journal of cancer research : Gann| PubMed ID: 11985784

2002
2002
2002
New polyphosphoramidate with a spermidine side chain as a gene carrier.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 12220847

2002
2003
2003
2003
2003
Polyphosphoesters in drug and gene delivery.

Advanced drug delivery reviews| PubMed ID: 12706047

2003
2003
2003
2003
Multifunctional nanorods for gene delivery.

Nature materials| PubMed ID: 12970757

2003
Poly(D,L-lactide-co-ethyl ethylene phosphate)s as new drug carriers.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 14499184

2003
2003
2003
2003
2003
High density of immobilized galactose ligand enhances hepatocyte attachment and function.

Journal of biomedical materials research. Part A| PubMed ID: 14624494

2003
2004
2004
2004
Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 15014006

2004
2004
2004
2004
In vitro release of vascular endothelial growth factor from gadolinium-doped biodegradable microspheres.

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine| PubMed ID: 15170848

2004
Poly(phosphoester) ionomers as tissue-engineering scaffolds.

Journal of biomedical materials research. Part B, Applied biomaterials| PubMed ID: 15199588

2004
Evaluation of collagen and methylated collagen as gene carriers.

International journal of pharmaceutics| PubMed ID: 15234800

2004
Biodegradable polyphosphoester micelles for gene delivery.

Journal of pharmaceutical sciences| PubMed ID: 15236461

2004
2005
2004
Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering.

Journal of biomedical materials research. Part A| PubMed ID: 15499568

2004
2005
2004
2005
2005
Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression.

Journal of biomaterials science. Polymer edition| PubMed ID: 15648571

2004
Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 15681095

2005
MR imaging of biodegradable polymeric microparticles: a potential method of monitoring local drug delivery.

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine| PubMed ID: 15723408

2005
2005
2005
2005
Controlled release from fibers of polyelectrolyte complexes.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 15907585

2005
2005
2005
2005
2006
2006
2006
2005
2005
2005
2005
2005
2006
2006
2006
2005
2006
Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 16497560

2006
2006
2006
2006
2007
2005
2006
Enhancing efficacy of HIV gag DNA vaccine by local delivery of GM-CSF in murine and macaque models.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research| PubMed ID: 16734558

2006
2006
Natural polymers for gene delivery and tissue engineering.

Advanced drug delivery reviews| PubMed ID: 16762443

2006
2006
2006
2006
2006
2006
2006
2006
Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 17081642

2006
2007
Biomaterials approach to expand and direct differentiation of stem cells.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 17264853

2007
Significance of synthetic nanostructures in dictating cellular response.

Nanomedicine : nanotechnology, biology, and medicine| PubMed ID: 17292053

2005
Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 17356539

2007
2006
2008
2007
2007
2007
2006
2007
2007
2006
Chitosan nanoparticles for oral drug and gene delivery.

International journal of nanomedicine| PubMed ID: 17722528

2006
2008
2008
Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 18180773

2008
2008
Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors.

Journal of biomedical materials research. Part A| PubMed ID: 18404706

2009
Radiation-inducible caspase-8 gene therapy for malignant brain tumors.

International journal of radiation oncology, biology, physics| PubMed ID: 18407431

2008
2007
2007
Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 18634839

2008
Viscoelastic behaviour of human mesenchymal stem cells.

BMC cell biology| PubMed ID: 18644160

2008
Engineering strategies to enhance nanoparticle-mediated oral delivery.

Journal of biomaterials science. Polymer edition| PubMed ID: 19017470

2008
2006
2009
Sustained viral gene delivery through core-shell fibers.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 19539680

2009
Electrohydrodynamics: A facile technique to fabricate drug delivery systems.

Advanced drug delivery reviews| PubMed ID: 19651167

2009
Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery.

Journal of the Royal Society, Interface / the Royal Society| PubMed ID: 19734186

2010
2008
2009
Mast cell-derived particles deliver peripheral signals to remote lymph nodes.

The Journal of experimental medicine| PubMed ID: 19808250

2009
2010
Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences| PubMed ID: 19913612

2010
2010
Microscale oral delivery devices incorporating nanoparticles.

Nanomedicine (London, England)| PubMed ID: 20148626

2010
2009
Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 20179678

2010
2010
Electrosprayed core-shell microspheres for protein delivery.

Chemical communications (Cambridge, England)| PubMed ID: 20485844

2010
Polymer hydrogels: Chaperoning vaccines.

Nature materials| PubMed ID: 20571480

2010
2010
Quantum dot-based theranostics.

Nanoscale| PubMed ID: 20648364

2010
Nanoscale surfacing for regenerative medicine.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology| PubMed ID: 20803682

2010
2011
2011
2011
2011
2010
2011
2010
2011
2011
2011
2011
Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture.

Integrative biology : quantitative biosciences from nano to macro| PubMed ID: 21695342

2011
2011
Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres.

The spine journal : official journal of the North American Spine Society| PubMed ID: 21843975

2011
Nucleic acid-binding polymers as anti-inflammatory agents.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21844380

2011
Mechanical behavior of human embryonic stem cell pellet under unconfined compression.

Biomechanics and modeling in mechanobiology| PubMed ID: 21858691

2011
2011
2011
2011
2012
Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference| PubMed ID: 22255034

2011
2012
Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 22326811

2012
2018
2018
Editorial.

Biomaterials| PubMed ID: 25443403

2015
2014
2015
2015
2015
2015
2015
2015
MicroRNA delivery for regenerative medicine.

Advanced drug delivery reviews| PubMed ID: 26024978

2015
3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 26033288

2015
2015
2015
2016
2016
2016
Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions.

Small (Weinheim an der Bergstrasse, Germany)| PubMed ID: 27038291

2016
2016
2016
Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 27091696

2016
Signal-on Protein Detection via Dye Translocation between Aptamer and Quantum Dot.

ACS applied materials & interfaces| PubMed ID: 27101438

2016
2016
Polycationic Nanofibers for Nucleic Acid Scavenging.

Biomacromolecules| PubMed ID: 27741396

2016
2016
2017
2017
2017
2017
Progress in Nanotheranostics Based on Mesoporous Silica Nanomaterial Platforms.

ACS applied materials & interfaces| PubMed ID: 28274115

2017
Diverse Applications of Nanomedicine.

ACS nano| PubMed ID: 28290206

2017
2017
2017
2017
2017
Functional Recovery of Contused Spinal Cord in Rat with the Injection of Optimal-Dosed Cerium Oxide Nanoparticles.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 29051850

2017
2017
2017
Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing.

Integrative biology : quantitative biosciences from nano to macro| PubMed ID: 29168874

2017
2018
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 29686087

2018
2018
2018
2018
2018
2018
Folding artificial mucosa with cell-laden hydrogels guided by mechanics models.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 29967135

2018
2018
2017
HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Argonaute.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 30027026

2018
2018
Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 30128227

2018
2018
2018
2016
2019
2018
2019
2019
Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment.

Angewandte Chemie (International ed. in English)| PubMed ID: 30724436

2019
2019
Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes.

Journal of controlled release : official journal of the Controlled Release Society| PubMed ID: 30894322

2019
2019
2019
2019
Engineering Cell Membrane-Based Nanotherapeutics to Target Inflammation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 31406672

2019
2020
2020
2020
2020
2020
Dual-Color Plasmonic Nanosensor for Radiation Dosimetry.

ACS applied materials & interfaces| PubMed ID: 32337977

2020
2020
2020
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 32546520

2020
2020
2020
2021
2018
2020
2020
2020
2020
A Versatile Nonviral Delivery System for Multiplex Gene-Editing in the Liver.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 33053221

2020
A materials-science perspective on tackling COVID-19.

Nature reviews. Materials| PubMed ID: 33078077

2020
2020
2020
2020
2020
2019
2021
2021
2021
2021
2021
2021
Inhibition of DNA replication initiation by silver nanoclusters.

Nucleic acids research| PubMed ID: 33905520

2021
2021
2020
2021
Drug delivery carriers with therapeutic functions.

Advanced drug delivery reviews| PubMed ID: 34302897

2021
A Versatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 34386315

2021
2021
Light: A Magical Tool for Controlled Drug Delivery.

Advanced functional materials| PubMed ID: 34483808

2020
2021
2021
2020
2022
2021
2022
2022
Design of therapeutic biomaterials to control inflammation.

Nature reviews. Materials| PubMed ID: 35251702

2022
2022
Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses.

Signal transduction and targeted therapy| PubMed ID: 35338114

2022
2022
2022
2022
Material Engineering in Gut Microbiome and Human Health.

Research (Washington, D.C.)| PubMed ID: 35958108

2022
2022
2022
2022
2023
2022
2022
Therapeutic Nanocarriers Inhibit Chemotherapy-Induced Breast Cancer Metastasis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 36220339

2022
2023
2022
2023
2023
2023
2022
2022
2023
2023
2023
The Year 2022 in biomaterials research: A perspective from the editors of six leading journals.

Journal of biomedical materials research. Part A| PubMed ID: 36951261

2023
Circulating Cell-Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen-Induced Liver Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 37035952

2023
2023
MDM2-Targeting Reassembly Peptide (TRAP) Nanoparticles for p53-Based Cancer Therapy.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 37474204

2023
2023
2023
Focused ultrasound-mediated brain genome editing.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 37579143

2023
2023
Delivery of biologics: Topical administration.

Biomaterials| PubMed ID: 37690380

2023
2023
2023
2024
2024
2024
2023
2024
Human vascular organoids with a mosaic mutation recapitulate Proteus syndrome.

bioRxiv : the preprint server for biology| PubMed ID: 38328122

2024
2024
2024
Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 38549185

2024
2024
2024
Multiscale engineering of brain organoids for disease modeling.

Advanced drug delivery reviews| PubMed ID: 38810702

2024
2022
Bacterial therapies at the interface of synthetic biology and nanomedicine.

Nature reviews bioengineering| PubMed ID: 38962719

2024
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 38965824

2024
2024
2024
2025
2024
2024
2024
2025
Nanomaterial-Mediated Reprogramming of Macrophages to Inhibit Refractory Muscle Fibrosis.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 39548911

2024
Magnetic soft microrobots for erectile dysfunction therapy.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 39556757

2024
Sound innovations for biofabrication and tissue engineering.

Microsystems & nanoengineering| PubMed ID: 39562793

2024