Lars Kaestner

Institute for Molecular Cell Biology, Universty of Saarland

Affiliated withUniversty of Saarland Saarland University

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 35	2009
Publication title Cited by 6	2023

Other Publications

Article	Year
Ion channels in the human red blood cell membrane: their further investigation and physiological relevance. Bioelectrochemistry (Amsterdam, Netherlands)\| PubMed ID: 11786344	2002
Zinc octa-n-alkyl phthalocyanines in photodynamic therapy: photophysical properties, accumulation and apoptosis in cell cultures, studies in erythrocytes and topical application to Balb/c mi... Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 12859150	2003
Red blood cell ghosts and intact red blood cells as complementary models in photodynamic cell research. Bioelectrochemistry (Amsterdam, Netherlands)\| PubMed ID: 15039014	2004
Erythrocytes-the 'house elves' of photodynamic therapy. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 15570383	2004
Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process. Thrombosis and haemostasis\| PubMed ID: 15583732	2004
Calcium imaging of individual erythrocytes: problems and approaches. Cell calcium\| PubMed ID: 16242187	2006
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. Cell calcium\| PubMed ID: 16289269	2006
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circulation research\| PubMed ID: 16946137	2006
Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane. The Journal of biological chemistry\| PubMed ID: 17056596	2006
Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse. Cell calcium\| PubMed ID: 17580090	2007
A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes. Cell calcium\| PubMed ID: 17822759	2008
Identification of PatL1, a human homolog to yeast P body component Pat1. Biochimica et biophysica acta\| PubMed ID: 17936923	2007
Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells. International journal of cancer. Journal international du cancer\| PubMed ID: 18688854	2008
DNA double-strand break rejoining in complex normal tissues. International journal of radiation oncology, biology, physics\| PubMed ID: 18805648	2008
A system for optical high resolution screening of electrical excitable cells. Cell calcium\| PubMed ID: 20036001	2010
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling. Cardiovascular research\| PubMed ID: 20211865	2010
Functional NMDA receptors in rat erythrocytes. American journal of physiology. Cell physiology\| PubMed ID: 20457837	2010
Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during long term culture. Journal of molecular and cellular cardiology\| PubMed ID: 20540947	2010
Optical action potential screening on adult ventricular myocytes as an alternative QT-screen. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 21471717	2011
The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells inÂ vitro and inÂ vivo. Journal of neuro-oncology\| PubMed ID: 21607667	2011
Stimulation of human red blood cells leads to Ca2+-mediated intercellular adhesion. Cell calcium\| PubMed ID: 21616535	2011
Screening action potentials: the power of light. Frontiers in pharmacology\| PubMed ID: 21847381	2011
Lysophosphatidic acid induced red blood cell aggregation in vitro. Bioelectrochemistry (Amsterdam, Netherlands)\| PubMed ID: 21890432	2011
Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement. Journal of molecular and cellular cardiology\| PubMed ID: 21930133	2012
ATOM - an OMERO add-on for automated import of image data. BMC research notes\| PubMed ID: 21978452	2011
Regulation of phosphatidylserine exposure in red blood cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 22178937	2011
Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism. PloS one\| PubMed ID: 22470521	2012
Erythrocytes and erythropoietin. International journal of cell biology\| PubMed ID: 22481941	2011
Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes. Cardiovascular research\| PubMed ID: 22562663	2012
Noise-free visualization of microscopic calcium signaling by pixel-wise fitting. Circulation research\| PubMed ID: 22619280	2012
Accumulation of DNA damage in complex normal tissues after protracted low-dose radiation. DNA repair\| PubMed ID: 22947398	2012
Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1. Cell calcium\| PubMed ID: 23631848	2013
Calcium in red blood cells-a perilous balance. International journal of molecular sciences\| PubMed ID: 23698771	2013
Protein kinase Cα and P-type Ca channel CaV2.1 in red blood cell calcium signalling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 23817128	2013
Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation. PloS one\| PubMed ID: 23840765	2013
Irisin and exercise training in humans - results from a randomized controlled training trial. BMC medicine\| PubMed ID: 24191966	2013
Calcium homeostasis in red blood cells of dialysis patients in dependence of erythropoietin treatment. Frontiers in physiology\| PubMed ID: 24478727	2014
Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Medicine and science in sports and exercise\| PubMed ID: 24566753	2014
Targeted activation of conventional and novel protein kinases C through differential translocation patterns. Molecular and cellular biology\| PubMed ID: 24732802	2014
Genetically encoded Ca2+ indicators in cardiac myocytes. Circulation research\| PubMed ID: 24812351	2014
Differential Behavior of Fibroblasts and Epithelial Cells on Structured Implant Abutment Materials: A Comparison of Materials and Surface Topographies. Clinical implant dentistry and related research\| PubMed ID: 25066589	2015
Regulation of red cell life-span, erythropoiesis, senescence, and clearance. Frontiers in physiology\| PubMed ID: 25101005	2014
Detecting calcium in cardiac muscle: fluorescence to dye for. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 25260614	2014
Two-photon photolysis combined with a kilobeam array scanner to probe calcium signaling in cardiomyocytes. Cold Spring Harbor protocols\| PubMed ID: 25368304	2014
Multi-beam two-photon imaging of fast Ca2+ signals in the Langendorff mouse heart. Cold Spring Harbor protocols\| PubMed ID: 25368305	2014
Multi-channel imaging of cellular signaling: interplay of Ca2+ and conventional protein kinase C. Cold Spring Harbor protocols\| PubMed ID: 25368306	2014
Differential targeting of cPKC and nPKC decodes and regulates Ca²⁺ and lipid signalling. Biochemical Society transactions\| PubMed ID: 25399567	2014
Two-dimensional imaging of fast intracellular Ca2+ release. Cold Spring Harbor protocols\| PubMed ID: 25447280	2014
Confocal FLIM of genetically encoded FRET sensors for quantitative Ca2+ imaging. Cold Spring Harbor protocols\| PubMed ID: 25447281	2014
Conceptual and technical aspects of transfection and gene delivery. Bioorganic & medicinal chemistry letters\| PubMed ID: 25677659	2015
Channelizing the red blood cell: molecular biology competes with patch-clamp. Frontiers in molecular biosciences\| PubMed ID: 26322315	2015
Genetically Encoded Voltage Indicators in Circulation Research. International journal of molecular sciences\| PubMed ID: 26370981	2015
Cardiac remodeling in Gαq and Gα11 knockout mice. International journal of cardiology\| PubMed ID: 26476043	2016
Endothelin-1-induced remodelling of murine adult ventricular myocytes. Cell calcium\| PubMed ID: 26794932	2016
Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca(2+) handling, and red cell function in athletes and untrained subjects. Cell calcium\| PubMed ID: 27292137	2016
Red Cell Properties after Different Modes of Blood Transportation. Frontiers in physiology\| PubMed ID: 27471472	2016
Cardiac N-methyl D-aspartate Receptors as a Pharmacological Target. Journal of cardiovascular pharmacology\| PubMed ID: 27525575	2016
Hyperaldosteronism induces left atrial systolic and diastolic dysfunction. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27614224	2016
Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 27771709	2016
C2-domain mediated nano-cluster formation increases calcium signaling efficiency. Scientific reports\| PubMed ID: 27808106	2016
The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes. Scientific reports\| PubMed ID: 28045119	2017
PKCα diffusion and translocation are independent of an intact cytoskeleton. Scientific reports\| PubMed ID: 28352102	2017
'Gardos Channelopathy': a variant of hereditary Stomatocytosis with complex molecular regulation. Scientific reports\| PubMed ID: 28496185	2017
The potential of erythrocytes as cellular aging models. Cell death and differentiation\| PubMed ID: 28622292	2017
Trifluoperazine-Induced Suicidal Erythrocyte Death and S-Nitrosylation Inhibition, Reversed by the Nitric Oxide Donor Sodium Nitroprusside. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 28793283	2017
The buckling instability of aggregating red blood cells. Scientific reports\| PubMed ID: 28801570	2017
Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia? Frontiers in physiology\| PubMed ID: 28932200	2017
NMDA Receptor Activity in Circulating Red Blood Cells: Methods of Detection. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28986879	2017
An adaptation of astronomical image processing enables characterization and functional 3D mapping of individual sites of excitation-contraction coupling in rat cardiac muscle. eLife\| PubMed ID: 29135437	2017
Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca-mediated Adaptations. Frontiers in physiology\| PubMed ID: 29259557	2017
Voltage-Activated Ion Channels in Non-excitable Cells-A Viewpoint Regarding Their Physiological Justification. Frontiers in physiology\| PubMed ID: 29755371	2018
The Red Blood Cells on the Move! Frontiers in physiology\| PubMed ID: 29765336	2018
Classification of red blood cell shapes in flow using outlier tolerant machine learning. PLoS computational biology\| PubMed ID: 29906283	2018
Squeezing for Life - Properties of Red Blood Cell Deformability. Frontiers in physiology\| PubMed ID: 29910743	2018
Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels. Biophysical journal\| PubMed ID: 30021115	2018
A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp. Haematologica\| PubMed ID: 30237269	2019
DREADD technology reveals major impact of Gq signalling on cardiac electrophysiology. Cardiovascular research\| PubMed ID: 30321287	2019
Editorial: The Red Cell Life-Cycle From Erythropoiesis to Clearance. Frontiers in physiology\| PubMed ID: 30467481	2018
Commentary: Voltage Gating of Mechanosensitive PIEZO Channels. Frontiers in physiology\| PubMed ID: 30524293	2018
A Previously Unrecognized Ca-inhibited Nonselective Cation Channel in Red Blood Cells. HemaSphere\| PubMed ID: 30887009	2018
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias. Frontiers in physiology\| PubMed ID: 31040790	2019
Glutaraldehyde - A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells. Frontiers in physiology\| PubMed ID: 31139090	2019
Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis. Haematologica\| PubMed ID: 31147440	2019
The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence. Frontiers in physiology\| PubMed ID: 31275166	2019
Red Blood Cells: Chasing Interactions. Frontiers in physiology\| PubMed ID: 31417415	2019
Large scale, unbiased analysis of elementary calcium signaling events in cardiac myocytes. Journal of molecular and cellular cardiology\| PubMed ID: 31419438	2019
Calcium Channels and Calcium-Regulated Channels in Human Red Blood Cells. Advances in experimental medicine and biology\| PubMed ID: 31646528	2020
Cross-sectional focusing of red blood cells in a constricted microfluidic channel. Soft matter\| PubMed ID: 31808773	2020
Intracellular Ca Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on Cell Age. Frontiers in physiology\| PubMed ID: 31998145	2019
Correction: Cross-sectional focusing of red blood cells in a constricted microfluidic channel. Soft matter\| PubMed ID: 32039425	2020
Heterogeneity of Red Blood Cells: Causes and Consequences. Frontiers in physiology\| PubMed ID: 32457644	2020
Trends in the Development of Diagnostic Tools for Red Blood Cell-Related Diseases and Anemias. Frontiers in physiology\| PubMed ID: 32528298	2020
Early Career Scientists' Guide to the Red Blood Cell - Don't Panic! Frontiers in physiology\| PubMed ID: 32903637	2020
Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells. Cell communication and signaling : CCS\| PubMed ID: 32948210	2020
Artificial intelligence meets hematology. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis\| PubMed ID: 33153901	2020
Editorial: Red Blood Cells at the Mount of Truth: Highlights of the 22nd Meeting of the European Red Cell Research Society. Frontiers in physiology\| PubMed ID: 33329062	2020
Gardos channelopathy: functional analysis of a novel KCNN4 variant. Blood advances\| PubMed ID: 33351129	2020
Lingering Dynamics in Microvascular Blood Flow. Biophysical journal\| PubMed ID: 33359171	2021
Mechanical Stress Induces Ca-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis. International journal of molecular sciences\| PubMed ID: 33478008	2021
Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients. Cells\| PubMed ID: 33672679	2021
Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn. Acta physiologica (Oxford, England)\| PubMed ID: 33729672	2021
Acanthocyte Sedimentation Rate as a Diagnostic Biomarker for Neuroacanthocytosis Syndromes: Experimental Evidence and Physical Justification. Cells\| PubMed ID: 33918219	2021
Red blood cell phenotyping from 3D confocal images using artificial neural networks. PLoS computational biology\| PubMed ID: 33983926	2021
The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib. Biomolecules\| PubMed ID: 34066168	2021
The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel-A New Druggable Ca Pathway in Red Cells, Implications for Red Cell Ion Homeostasis. Frontiers in physiology\| PubMed ID: 34177620	2021
Rare Anemias: Are Their Names Just Smoke and Mirrors? Frontiers in physiology\| PubMed ID: 34177628	2021
"So is science …" : No evidence for neocytolysis on descending the mountains (Response to Rice and Gunga). Acta physiologica (Oxford, England)\| PubMed ID: 34197698	2021
Of mice and men : How to achieve a better life with lower total Hb mass after returning from hypoxia to normoxia. (response to Song and colleagues). Acta physiologica (Oxford, England)\| PubMed ID: 34292651	2021
Mechanistic ion channel interactions in red cells of patients with Gárdos channelopathy. Blood advances\| PubMed ID: 34468723	2021
Imaging Erythrocyte Sedimentation in Whole Blood. Frontiers in physiology\| PubMed ID: 35153805	2021
The Function of Ion Channels and Membrane Potential in Red Blood Cells: Toward a Systematic Analysis of the Erythroid Channelome. Frontiers in physiology\| PubMed ID: 35177994	2022
Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer. American journal of hematology\| PubMed ID: 35179248	2022
Erythrocyte Sedimentation: Collapse of a High-Volume-Fraction Soft-Particle Gel. Physical review letters\| PubMed ID: 35275655	2022
Erythrocyte sedimentation: Effect of aggregation energy on gel structure during collapse. Physical review. E\| PubMed ID: 35291110	2022
In Vitro Erythropoiesis at Different pO Induces Adaptations That Are Independent of Prior Systemic Exposure to Hypoxia. Cells\| PubMed ID: 35406648	2022
The Relation Between Extracellular Vesicles Released From Red Blood Cells, Their Cargo, and the Clearance by Macrophages. Frontiers in physiology\| PubMed ID: 35432007	2022
Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium. Frontiers in physiology\| PubMed ID: 35444561	2022
Continuous Percoll Gradient Centrifugation of Erythrocytes-Explanation of Cellular Bands and Compromised Age Separation. Cells\| PubMed ID: 35455975	2022
Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications. Frontiers in physiology\| PubMed ID: 35574449	2022
Artificial intelligence: Training the trainer. British journal of haematology\| PubMed ID: 35822904	2022
Space anemia unexplained: Red blood cells seem to be space-proof. American journal of hematology\| PubMed ID: 35836385	2022
A pilot clinical phase II trial MemSID: Acute and durable changes of red blood cells of sickle cell disease patients on memantine treatment. EJHaem\| PubMed ID: 35847705	2020
Editorial: Insights in red blood cell physiology: 2021. Frontiers in physiology\| PubMed ID: 36117690	2022
Commentary: Acanthocytes identified in Huntington's disease. Frontiers in neuroscience\| PubMed ID: 36408380	2022
Hemoglobin is an oxygen-dependent glutathione buffer adapting the intracellular reduced glutathione levels to oxygen availability. Redox biology\| PubMed ID: 36413919	2022
Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept. Blood advances\| PubMed ID: 36490356	2023
Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19. eLife\| PubMed ID: 36537079	2022
Editorial: Comparative biology of red blood cells. Frontiers in physiology\| PubMed ID: 36589422	2022
Editorial: Images from red cell. Frontiers in physiology\| PubMed ID: 36714320	2022
Red blood cell lingering modulates hematocrit distribution in the microcirculation. Biophysical journal\| PubMed ID: 36932676	2023