Roberto Weigert

Intracellular Membrane Trafficking Unit, National Institutes of Health

Affiliated withNational Institutes of Health National Cancer Institute

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 18	2013
Publication title Cited by 2	2022
Publication title Cited by 3	2022

Other Publications

Article	Year
Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides. Molecular biology of the cell\| PubMed ID: 12589044	2003
A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14585930	2003
Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Molecular biology of the cell\| PubMed ID: 15146059	2004
Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Molecular biology of the cell\| PubMed ID: 15181155	2004
Multiple activities for Arf1 at the Golgi complex. Biochimica et biophysica acta\| PubMed ID: 15979507	2005
Fluorescent microscopy-based assays to study the role of Rab22a in clathrin-independent endocytosis. Methods in enzymology\| PubMed ID: 16473591	2005
Intravital two-photon microscopy for studying the uptake and trafficking of fluorescently conjugated molecules in live rodents. Traffic (Copenhagen, Denmark)\| PubMed ID: 18647170	2008
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS nano\| PubMed ID: 19236065	2009
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Molecular and cellular biology\| PubMed ID: 19255141	2009
Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis. Traffic (Copenhagen, Denmark)\| PubMed ID: 19302270	2009
The effect of hypusine modification on the intracellular localization of eIF5A. Biochemical and biophysical research communications\| PubMed ID: 19379712	2009
Myosin Vc is a molecular motor that functions in secretory granule trafficking. Molecular biology of the cell\| PubMed ID: 19741097	2009
Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. American journal of physiology. Cell physiology\| PubMed ID: 19794147	2009
Intravital microscopy: a novel tool to study cell biology in living animals. Histochemistry and cell biology\| PubMed ID: 20372919	2010
Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Molecular and cellular biology\| PubMed ID: 20385769	2010
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nature genetics\| PubMed ID: 20657595	2010
Intravital microscopy as a tool to study drug delivery in preclinical studies. Advanced drug delivery reviews\| PubMed ID: 20933026	2011
Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21694498	2011
The cyclooxygenase-2 pathway via the PGEâ‚‚ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. Journal of neurochemistry\| PubMed ID: 21699540	2012
Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21808006	2011
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Science signaling\| PubMed ID: 21934106	2011
Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer research\| PubMed ID: 21975930	2011
Regulated exocytosis: novel insights from intravital microscopy. Traffic (Copenhagen, Denmark)\| PubMed ID: 22243493	2012
Linking differences in membrane tension with the requirement for a contractile actomyosin scaffold during exocytosis in salivary glands. Communicative & integrative biology\| PubMed ID: 22482019	2012
Plasmid DNA is internalized from the apical plasma membrane of the salivary gland epithelium in live animals. Histochemistry and cell biology\| PubMed ID: 22544351	2012
Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22753477	2012
Homeostasis of the apical plasma membrane during regulated exocytosis in the salivary glands of live rodents. Bioarchitecture\| PubMed ID: 22754613	2011
Multiple roles for the actin cytoskeleton during regulated exocytosis. Cellular and molecular life sciences : CMLS\| PubMed ID: 22986507	2013
Intravital microscopy: A practical guide on imaging intracellular structures in live animals. Bioarchitecture\| PubMed ID: 22992750	2012
Intravital microscopy to image membrane trafficking in live rats. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23027003	2013
Rab25 regulates invasion and metastasis in head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23340300	2013
Imaging cell biology in live animals: ready for prime time. The Journal of cell biology\| PubMed ID: 23798727	2013
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. The Journal of cell biology\| PubMed ID: 24019537	2013
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nature medicine\| PubMed ID: 24056772	2013
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. The Journal of clinical investigation\| PubMed ID: 24177428	2013
Endosomes derived from clathrin-independent endocytosis serve as precursors for endothelial lumen formation. PloS one\| PubMed ID: 24282620	2013
Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Current biology : CB\| PubMed ID: 24613307	2014
Imaging the dynamics of endocytosis in live mammalian tissues. Cold Spring Harbor perspectives in biology\| PubMed ID: 24691962	2014
Two-photon excitation improves multifocal structured illumination microscopy in thick scattering tissue. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706872	2014
Intravital Microscopy Reveals Differences in the Kinetics of Endocytic Pathways between Cell Cultures and Live Animals. Cells\| PubMed ID: 24710546	2012
Probing the role of the actin cytoskeleton during regulated exocytosis by intravital microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24947398	2014
Altered endosome biogenesis in prostate cancer has biomarker potential. Molecular cancer research : MCR\| PubMed ID: 25080433	2014
In vivo tissue-wide synchronization of mitochondrial metabolic oscillations. Cell reports\| PubMed ID: 25373899	2014
SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25466898	2015
Polyethylenimine-mediated expression of transgenes in the acinar cells of rats salivary glands in vivo. Frontiers in cell and developmental biology\| PubMed ID: 25621283	2014
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications\| PubMed ID: 25857352	2015
Imaging membrane remodeling during regulated exocytosis in live mice. Experimental cell research\| PubMed ID: 26160452	2015
Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo. Nature communications\| PubMed ID: 26639106	2015
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood\| PubMed ID: 26647393	2016
Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Experimental eye research\| PubMed ID: 27179411	2017
Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology (Baltimore, Md.)\| PubMed ID: 27396550	2016
Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β. Molecular cell\| PubMed ID: 27746021	2016
Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow. The Journal of clinical investigation\| PubMed ID: 27820703	2016
Kinetics of milk lipid droplet transport, growth, and secretion revealed by intravital imaging: lipid droplet release is intermittently stimulated by oxytocin. Molecular biology of the cell\| PubMed ID: 28179456	2017
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule. Cell systems\| PubMed ID: 28330614	2017
Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals. The Journal of cell biology\| PubMed ID: 28600434	2017
Non-invasive intravital imaging of head and neck squamous cell carcinomas in live mice. Methods (San Diego, Calif.)\| PubMed ID: 28780320	2017
ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 28834398	2017
Isoform-specific roles of NMII drive membrane remodeling in vivo. Cell cycle (Georgetown, Tex.)\| PubMed ID: 28937881	2017
Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake. Cell reports\| PubMed ID: 29281816	2017
Parallel assembly of actin and tropomyosin, but not myosin II, during actin filament formation in live mice. Journal of cell science\| PubMed ID: 29487177	2018
ONC201 kills breast cancer cells by targeting mitochondria. Oncotarget\| PubMed ID: 29719618	2018
The Actomyosin Cytoskeleton Drives Micron-Scale Membrane Remodeling In Vivo Via the Generation of Mechanical Forces to Balance Membrane Tension Gradients. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 30080263	2018
Symposium review: Intravital imaging of the lactating mammary gland in live mice reveals novel aspects of milk-lipid secretion. Journal of dairy science\| PubMed ID: 30471915	2019
Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals. Molecular biology of the cell\| PubMed ID: 30540520	2019
Mitochondrial Populations Exhibit Differential Dynamic Responses to Increased Energy Demand during Exocytosis In Vivo. iScience\| PubMed ID: 30661001	2019
Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7. Frontiers in immunology\| PubMed ID: 30891040	2019
Intravital microscopy in mammalian multicellular organisms. Current opinion in cell biology\| PubMed ID: 31125832	2019
Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice. Nature cell biology\| PubMed ID: 31358965	2019
Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy. Communications biology\| PubMed ID: 31925335	2020
Cdc42 controls secretory granules morphology in rodent salivary glands in vivo. Communicative & integrative biology\| PubMed ID: 32128025	2020
A role for keratins in supporting mitochondrial organization and function in skin keratinocytes. Molecular biology of the cell\| PubMed ID: 32213122	2020
The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation. The Journal of cell biology\| PubMed ID: 32854115	2020
Collective cancer cell invasion requires RNA accumulation at the invasive front. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33060293	2020
Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9. Molecular therapy. Methods & clinical development\| PubMed ID: 33294494	2020
Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling. The Journal of clinical investigation\| PubMed ID: 33822776	2021
Method for Acute Intravital Imaging of the Large Intestine in Live Mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34028723	2021
The butyrophilin 1a1 knockout mouse revisited: Ablation of leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB bioAdvances\| PubMed ID: 34938960	2021