Stephen C. Harrison

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2009

Other Publications

Article	Year
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Molecular cell\| PubMed ID: 11804587	2002
Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3. Cell\| PubMed ID: 11832217	2002
Don C. Wiley (1944-2001). Cell\| PubMed ID: 11853666	2002
Don C. Wiley (1944--2001). Molecular cell\| PubMed ID: 11864596	2002
The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. The EMBO journal\| PubMed ID: 11867517	2002
Atomic model of the papillomavirus capsid. The EMBO journal\| PubMed ID: 12234916	2002
Specificity and affinity of sialic acid binding by the rhesus rotavirus VP8* core. Journal of virology\| PubMed ID: 12239329	2002
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12357034	2002
RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell\| PubMed ID: 12464184	2002
How does radiation damage in protein crystals depend on X-ray dose? Structure (London, England : 1993)\| PubMed ID: 12517336	2003
Variation on an Src-like theme. Cell\| PubMed ID: 12654240	2003
Disulfide bonding among micro 1 trimers in mammalian reovirus outer capsid: a late and reversible step in virion morphogenesis. Journal of virology\| PubMed ID: 12692241	2003
A ligand-binding pocket in the dengue virus envelope glycoprotein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12759475	2003
An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nature structural biology\| PubMed ID: 12949491	2003
Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Molecular biology of the cell\| PubMed ID: 13679521	2003
Two distinct size classes of immature and mature subviral particles from tick-borne encephalitis virus. Journal of virology\| PubMed ID: 14557621	2003
X-ray structure of a protein-conducting channel. Nature\| PubMed ID: 14661030	2004
Whither structural biology? Nature structural & molecular biology\| PubMed ID: 14718917	2004
Structure of the dengue virus envelope protein after membrane fusion. Nature\| PubMed ID: 14737159	2004
Structure of the human transferrin receptor-transferrin complex. Cell\| PubMed ID: 14980223	2004
Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces. Virus research\| PubMed ID: 15010214	2004
A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. Journal of virology\| PubMed ID: 15078931	2004
Full-length influenza hemagglutinin HA2 refolds into the trimeric low-pH-induced conformation. Biochemistry\| PubMed ID: 15134464	2004
Discovery of antivirals against smallpox. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15249657	2004
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15326297	2004
Structural rearrangements in the membrane penetration protein of a non-enveloped virus. Nature\| PubMed ID: 15329727	2004
Crystal structure of the clathrin adaptor protein 1 core. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15377783	2004
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature\| PubMed ID: 15502812	2004
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature\| PubMed ID: 15502813	2004
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. The EMBO journal\| PubMed ID: 15510218	2004
Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15534202	2004
Crystal structure of the spindle assembly checkpoint protein Bub3. Journal of molecular biology\| PubMed ID: 15544799	2004
Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. Journal of virology\| PubMed ID: 15613349	2005
The yeast DASH complex forms closed rings on microtubules. Nature structural & molecular biology\| PubMed ID: 15640796	2005
Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure (London, England : 1993)\| PubMed ID: 15698564	2005
Structure of an unliganded simian immunodeficiency virus gp120 core. Nature\| PubMed ID: 15729334	2005
Molecular organization of the Ndc80 complex, an essential kinetochore component. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15809444	2005
The active conformation of the PAK1 kinase domain. Structure (London, England : 1993)\| PubMed ID: 15893667	2005
Mechanism of membrane fusion by viral envelope proteins. Advances in virus research\| PubMed ID: 16139596	2005
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science (New York, N.Y.)\| PubMed ID: 16166518	2005
Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution. Structure (London, England : 1993)\| PubMed ID: 16216585	2005
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature\| PubMed ID: 16319884	2005
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. The Journal of biological chemistry\| PubMed ID: 16339146	2006
Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. Journal of molecular biology\| PubMed ID: 16343539	2006
Single particle reconstruction of the human apo-transferrin-transferrin receptor complex. Journal of structural biology\| PubMed ID: 16343946	2005
Stu2p binds tubulin and undergoes an open-to-closed conformational change. The Journal of cell biology\| PubMed ID: 16567500	2006
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure (London, England : 1993)\| PubMed ID: 16765893	2006
Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. Journal of virology\| PubMed ID: 16809285	2006
Crystal structure of glycoprotein B from herpes simplex virus 1. Science (New York, N.Y.)\| PubMed ID: 16840698	2006
Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. Journal of structural biology\| PubMed ID: 16908193	2006
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16963566	2006
Reovirus mu1 structural rearrangements that mediate membrane penetration. Journal of virology\| PubMed ID: 17005655	2006
Restraining the conformation of HIV-1 gp120 by removing a flexible loop. The EMBO journal\| PubMed ID: 17006538	2006
Interactions between SARS coronavirus and its receptor. Advances in experimental medicine and biology\| PubMed ID: 17037534	2006
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. Journal of molecular biology\| PubMed ID: 17095010	2007
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nature structural & molecular biology\| PubMed ID: 17195848	2007
Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17227844	2007
Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure (London, England : 1993)\| PubMed ID: 17355870	2007
Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Molecular biology of the cell\| PubMed ID: 17460120	2007
Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. Journal of molecular biology\| PubMed ID: 17498738	2007
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. The Journal of biological chemistry\| PubMed ID: 17526488	2007
An atomic model of the interferon-beta enhanceosome. Cell\| PubMed ID: 17574024	2007
Structure and function of an essential component of the outer membrane protein assembly machine. Science (New York, N.Y.)\| PubMed ID: 17702946	2007
Interactions of lipids with aquaporin-0 and other membrane proteins. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 17932686	2008
Comments on the NIGMS PSI. Structure (London, England : 1993)\| PubMed ID: 17997957	2007
Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure (London, England : 1993)\| PubMed ID: 17997968	2007
Three-dimensional intricacies in protein-DNA recognition and transcriptional control. Nature structural & molecular biology\| PubMed ID: 18059448	2007
XMAP215 is a processive microtubule polymerase. Cell\| PubMed ID: 18191222	2008
Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18238898	2008
Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. The EMBO journal\| PubMed ID: 18369316	2008
Viral membrane fusion. Nature structural & molecular biology\| PubMed ID: 18596815	2008
Single-particle kinetics of influenza virus membrane fusion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18829437	2008
The pH sensor for flavivirus membrane fusion. The Journal of cell biology\| PubMed ID: 18936246	2008
Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure (London, England : 1993)\| PubMed ID: 19000820	2008
Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide. Journal of virology\| PubMed ID: 19439475	2009
Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19487668	2009
Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science (New York, N.Y.)\| PubMed ID: 19520960	2009
VP5* rearranges when rotavirus uncoats. Journal of virology\| PubMed ID: 19692464	2009
Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19906992	2009
A rotavirus spike protein conformational intermediate binds lipid bilayers. Journal of virology\| PubMed ID: 20007281	2010
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. The EMBO journal\| PubMed ID: 20033059	2010
X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. Journal of molecular biology\| PubMed ID: 20122940	2010
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nature structural & molecular biology\| PubMed ID: 20208545	2010
Subunit interactions in bovine papillomavirus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20308582	2010
Effect of mutations in VP5 hydrophobic loops on rotavirus cell entry. Journal of virology\| PubMed ID: 20375171	2010
Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS pathogens\| PubMed ID: 20386713	2010
Analysis of kinetic intermediates in single-particle dwell-time distributions. Biophysical journal\| PubMed ID: 20643053	2010
CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Developmental cell\| PubMed ID: 20708587	2010
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell\| PubMed ID: 20723757	2010
Structural biology: Conservation in vesicle coats. Nature\| PubMed ID: 20739998	2010
Virology. Looking inside adenovirus. Science (New York, N.Y.)\| PubMed ID: 20798308	2010
Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure (London, England : 1993)\| PubMed ID: 20826345	2010
Peptide inhibitors of flavivirus entry derived from the E protein stem. Journal of virology\| PubMed ID: 20881042	2010
Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure (London, England : 1993)\| PubMed ID: 20947020	2010
Mechanistic biology in the next quarter century. Molecular biology of the cell\| PubMed ID: 21079017	2010
Atomic model of an infectious rotavirus particle. The EMBO journal\| PubMed ID: 21157433	2011
Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nature structural & molecular biology\| PubMed ID: 21278753	2011
Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Current opinion in structural biology\| PubMed ID: 21333526	2011
Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21606327	2011
Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature\| PubMed ID: 21785437	2011
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21825125	2011
Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry. Journal of virology\| PubMed ID: 21849465	2011
Ndc10 is a platform for inner kinetochore assembly in budding yeast. Nature structural & molecular biology\| PubMed ID: 22139014	2012
RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. EMBO reports\| PubMed ID: 22322944	2012