Wolf Reik

Epigenetics Programme, The Babraham Institute

Affiliated withThe Babraham Institute University of Cambridge

Research Area

Biography

Wolf Reik has not added Biography.
If you are Wolf Reik and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 48	2013

Other Publications

Article	Year
Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis. Genes & development\| PubMed ID: 18559472	2008
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS genetics\| PubMed ID: 18584034	2008
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nature genetics\| PubMed ID: 18587395	2008
Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nature cell biology\| PubMed ID: 18836439	2008
Dynamic reprogramming of DNA methylation in the early mouse embryo. Developmental biology\| PubMed ID: 11784103	2002
Disruption of mesodermal enhancers for Igf2 in the minute mutant. Development (Cambridge, England)\| PubMed ID: 11923202	2002
Placental overgrowth in mice lacking the imprinted gene Ipl. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12032310	2002
Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature\| PubMed ID: 12087403	2002
Replication timing properties within the mouse distal chromosome 7 imprinting cluster. Bioscience, biotechnology, and biochemistry\| PubMed ID: 12092814	2002
Epigenetic reprogramming in mouse primordial germ cells. Mechanisms of development\| PubMed ID: 12204247	2002
Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer. Oncogene\| PubMed ID: 12370819	2002
Back to the beginning. Nature\| PubMed ID: 12432368	2002
Evidence that paternal expression of the epsilon-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia. American journal of human genetics\| PubMed ID: 12444570	2002
Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Seminars in cell & developmental biology\| PubMed ID: 12524012	2003
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (New York, N.Y. : 2000)\| PubMed ID: 12533790	2003
Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Human molecular genetics\| PubMed ID: 12554683	2003
Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. The Journal of physiology\| PubMed ID: 12562908	2003
The need for Eed. Nature genetics\| PubMed ID: 12665859	2003
Gene expression: Silent clones speak up. Nature\| PubMed ID: 12761530	2003
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Current biology : CB\| PubMed ID: 12842010	2003
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nature genetics\| PubMed ID: 12937418	2003
Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment? Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 14511488	2003
Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA. Human molecular genetics\| PubMed ID: 14532328	2003
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. Human molecular genetics\| PubMed ID: 14645199	2004
Genomic imprinting controls matrix attachment regions in the Igf2 gene. Molecular and cellular biology\| PubMed ID: 14645508	2003
Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region. Molecular and cellular biology\| PubMed ID: 15199123	2004
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nature genetics\| PubMed ID: 15273689	2004
Active genes dynamically colocalize to shared sites of ongoing transcription. Nature genetics\| PubMed ID: 15361872	2004
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. The Journal of biological chemistry\| PubMed ID: 15448152	2004
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nature genetics\| PubMed ID: 15516931	2004
Resourceful imprinting. Nature\| PubMed ID: 15525980	2004
The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Human molecular genetics\| PubMed ID: 15640248	2005
Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Developmental biology\| PubMed ID: 15766761	2005
Epigenetic reprogramming in mammals. Human molecular genetics\| PubMed ID: 15809273	2005
Co-evolution of X-chromosome inactivation and imprinting in mammals. Nature reviews. Genetics\| PubMed ID: 15818385	2005
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC genetics\| PubMed ID: 15885138	2005
Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. European journal of human genetics : EJHG\| PubMed ID: 15999116	2005
Mice deficient in APOBEC2 and APOBEC3. Molecular and cellular biology\| PubMed ID: 16055735	2005
Developmental biology: the X-inactivation yo-yo. Nature\| PubMed ID: 16292295	2005
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16365304	2005
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16815976	2006
Artificial sperm and epigenetic reprogramming. Nature biotechnology\| PubMed ID: 16964217	2006
Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development (Cambridge, England)\| PubMed ID: 17021040	2006
A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 17245608	2007
Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma\| PubMed ID: 17447080	2007
Stability and flexibility of epigenetic gene regulation in mammalian development. Nature\| PubMed ID: 17522676	2007
Non-coding transcripts in the H19 imprinting control region mediate gene silencing in transgenic Drosophila. EMBO reports\| PubMed ID: 17948025	2007
Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Human reproduction (Oxford, England)\| PubMed ID: 19073614	2009
DNA demethylation by DNA repair. Trends in genetics : TIG\| PubMed ID: 19144439	2009
The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development (Cambridge, England)\| PubMed ID: 19144718	2009
Evolution and functions of long noncoding RNAs. Cell\| PubMed ID: 19239885	2009
Germline mutation in NLRP2 (NALP2) in a familial imprinting disorder (Beckwith-Wiedemann Syndrome). PLoS genetics\| PubMed ID: 19300480	2009
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nature reviews. Molecular cell biology\| PubMed ID: 19603040	2009
Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13. Diabetes\| PubMed ID: 19794064	2010
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS genetics\| PubMed ID: 19956766	2009
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature\| PubMed ID: 20098412	2010
Wolf Reik: Inheritance beyond DNA. Interview by Nicole Lebrasseur. The Journal of cell biology\| PubMed ID: 20142419	2010
Evaluation of epigenetic marks in human embryos derived from IVF and ICSI. Human reproduction (Oxford, England)\| PubMed ID: 20634187	2010
Retrotransposons and germ cells: reproduction, death, and diversity. F1000 biology reports\| PubMed ID: 20948789	2010
Epigenetic reprogramming in plant and animal development. Science (New York, N.Y.)\| PubMed ID: 21030646	2010
Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21282203	2011
Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating... Experimental diabetes research\| PubMed ID: 21331382	2011
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nature communications\| PubMed ID: 21407207	2011
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature\| PubMed ID: 21460836	2011
DNA demethylases: a new epigenetic frontier in drug discovery. Drug discovery today\| PubMed ID: 21601651	2011
Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nature reviews. Genetics\| PubMed ID: 22083101	2012
BLUEPRINT to decode the epigenetic signature written in blood. Nature biotechnology\| PubMed ID: 22398613	2012
Methylome analysis using MeDIP-seq with low DNA concentrations. Nature protocols\| PubMed ID: 22402632	2012
Shifting behaviour: epigenetic reprogramming in eusocial insects. Current opinion in cell biology\| PubMed ID: 22429916	2012
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (New York, N.Y.)\| PubMed ID: 22539555	2012
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nature cell biology\| PubMed ID: 22684254	2012
Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status. PloS one\| PubMed ID: 22802932	2012
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome biology\| PubMed ID: 22902005	2012
Incomplete methylation reprogramming in SCNT embryos. Nature genetics\| PubMed ID: 22932499	2012
Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (Cambridge, England)\| PubMed ID: 22949617	2012
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 23166394	2013
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Molecular cell\| PubMed ID: 23219530	2012
Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation. BioTechniques\| PubMed ID: 23227987	2012
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature\| PubMed ID: 23395962	2013
Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells. Current opinion in cell biology\| PubMed ID: 23510682	2013
Reprogramming by cell fusion: boosted by Tets. Molecular cell\| PubMed ID: 23541036	2013
Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23641003	2013
Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PloS one\| PubMed ID: 23825703	2013
FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency. Cell stem cell\| PubMed ID: 23850245	2013