Andrew L. Kung

Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center

Affiliated withColumbia University Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2013

Other Publications

Article	Year
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11959990	2002
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12397173	2002
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer cell\| PubMed ID: 12620411	2003
Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science (New York, N.Y.)\| PubMed ID: 12690203	2003
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nature structural biology\| PubMed ID: 12778114	2003
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14595012	2003
Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Molecular imaging\| PubMed ID: 14717328	2003
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer cell\| PubMed ID: 15050914	2004
p53 targets simian virus 40 large T antigen for acetylation by CBP. Journal of virology\| PubMed ID: 15254196	2004
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer cell\| PubMed ID: 15261140	2004
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (New York, N.Y.)\| PubMed ID: 15353804	2004
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer cell\| PubMed ID: 15710326	2005
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes & development\| PubMed ID: 15713842	2005
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. The Journal of biological chemistry\| PubMed ID: 15951563	2005
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS genetics\| PubMed ID: 16103922	2005
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging. Cancer research\| PubMed ID: 16166309	2005
Antimyeloma activity of heat shock protein-90 inhibition. Blood\| PubMed ID: 16234364	2006
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer research\| PubMed ID: 16357147	2005
Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessin... Neurosurgery\| PubMed ID: 16462491	2006
Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16638967	2006
A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy. The American journal of pathology\| PubMed ID: 16723720	2006
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer cell\| PubMed ID: 16766266	2006
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood\| PubMed ID: 17068153	2007
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology\| PubMed ID: 17087936	2006
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood\| PubMed ID: 17119115	2007
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17121897	2006
Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. Cancer research\| PubMed ID: 17145884	2006
Practices and pitfalls of mouse cancer models in drug discovery. Advances in cancer research\| PubMed ID: 17161681	2007
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS medicine\| PubMed ID: 17425403	2007
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Molecular cancer therapeutics\| PubMed ID: 17620426	2007
Therapeutic targeting of apoptosis pathways in cancer. Current opinion in oncology\| PubMed ID: 18043263	2008
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood\| PubMed ID: 18184863	2008
Anti-apoptosis mechanisms in malignant gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18202424	2008
Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. Human molecular genetics\| PubMed ID: 18319327	2008
Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells. Molecular cancer therapeutics\| PubMed ID: 18445657	2008
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18607002	2008
The requirement for cyclin D function in tumor maintenance. Cancer cell\| PubMed ID: 23079655	2012
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage. Pigment cell & melanoma research\| PubMed ID: 18627530	2008
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins. The Journal of clinical investigation\| PubMed ID: 18677408	2008
Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells. Blood\| PubMed ID: 18820131	2008
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer cell\| PubMed ID: 18977325	2008
Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1. Clinical science (London, England : 1979)\| PubMed ID: 19014354	2009
HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood\| PubMed ID: 19056693	2009
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nature biotechnology\| PubMed ID: 19098899	2009
Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia (New York, N.Y.)\| PubMed ID: 19107234	2009
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood\| PubMed ID: 19139079	2009
Lipocalin 2 promotes breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19237579	2009
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19255431	2009
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. The Journal of biological chemistry\| PubMed ID: 19297328	2009
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. Journal of the National Cancer Institute\| PubMed ID: 19318631	2009
Identification of AML1-ETO modulators by chemical genomics. Blood\| PubMed ID: 19377049	2009
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. The Journal of clinical investigation\| PubMed ID: 19662677	2009
In vivo pharmacodynamic imaging of proteasome inhibition. Molecular imaging\| PubMed ID: 19723471	2009
Proteomic and genetic approaches identify Syk as an AML target. Cancer cell\| PubMed ID: 19800574	2009
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805293	2009
Systematic in vivo structure-function analysis of p300 in hematopoiesis. Blood\| PubMed ID: 19822904	2009
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia. Genome biology\| PubMed ID: 19828020	2009
Direct inhibition of the NOTCH transcription factor complex. Nature\| PubMed ID: 19907488	2009
An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer cell\| PubMed ID: 20227043	2010
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nature medicine\| PubMed ID: 20228816	2010
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood\| PubMed ID: 20299508	2010
Discovery and characterization of novel mutant FLT3 kinase inhibitors. Molecular cancer therapeutics\| PubMed ID: 20807780	2010
Selective inhibition of BET bromodomains. Nature\| PubMed ID: 20871596	2010
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer research\| PubMed ID: 20952506	2010
A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer cell\| PubMed ID: 21075307	2010
Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. Journal of neuro-oncology\| PubMed ID: 21246394	2011
Optical techniques for tracking multiple myeloma engraftment, growth, and response to therapy. Journal of biomedical optics\| PubMed ID: 21280893	2011
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature\| PubMed ID: 21368833	2011
Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer research\| PubMed ID: 21447744	2011
Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. Blood\| PubMed ID: 21555743	2011
A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo. Neuro-oncology\| PubMed ID: 21724651	2011
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer cell\| PubMed ID: 21741596	2011
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer cell\| PubMed ID: 21741597	2011
Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation. PloS one\| PubMed ID: 21750699	2011
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chemistry & biology\| PubMed ID: 21802004	2011
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. The Journal of experimental medicine\| PubMed ID: 21807868	2011
Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in exper... Fertility and sterility\| PubMed ID: 21821246	2011
BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell\| PubMed ID: 21889194	2011
Inactivation of a single copy of Crebbp selectively alters pre-mRNA processing in mouse hematopoietic stem cells. PloS one\| PubMed ID: 21901164	2011
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21949374	2011
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment. Blood\| PubMed ID: 22096244	2012
Mice heterozygous for CREB binding protein are hypersensitive to Î³-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Experimental hematology\| PubMed ID: 22198154	2011
Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma. Molecular cancer therapeutics\| PubMed ID: 22246439	2012
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood\| PubMed ID: 22262760	2012
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. The Journal of experimental medicine\| PubMed ID: 22271575	2012
Incongruity of imaging using fluorescent 2-DG conjugates compared to 18F-FDG in preclinical cancer models. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 22302178	2012
The intersection of genetic and chemical genomic screens identifies GSK-3Î± as a target in human acute myeloid leukemia. The Journal of clinical investigation\| PubMed ID: 22326953	2012
Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study. The journal of trauma and acute care surgery\| PubMed ID: 22327976	2012
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood\| PubMed ID: 22394600	2012
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature\| PubMed ID: 22425996	2012
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Cancer cell\| PubMed ID: 22516262	2012
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. The Journal of clinical investigation\| PubMed ID: 22622039	2012
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nature medicine\| PubMed ID: 22683780	2012
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood\| PubMed ID: 22904298	2012
Targeted disruption of the BCL9/Î²-catenin complex inhibits oncogenic Wnt signaling. Science translational medicine\| PubMed ID: 22914623	2012
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer cell\| PubMed ID: 22975378	2012
In vivo imaging of inflammatory phagocytes. Chemistry & biology\| PubMed ID: 22999887	2012
In Vivo Fluorescent Labeling of Tumor Cells with the HaloTagÂ® Technology. Current chemical genomics\| PubMed ID: 23115613	2012
The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations. Genes & cancer\| PubMed ID: 23264850	2012
Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Angiogenesis\| PubMed ID: 23334337	2013
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. British journal of haematology\| PubMed ID: 23373539	2013
Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 23422689	2013
Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer discovery\| PubMed ID: 23430699	2013
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer cell\| PubMed ID: 23434461	2013
Oncogenic BRAF regulates oxidative metabolism via PGC1Î± and MITF. Cancer cell\| PubMed ID: 23477830	2013
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer research\| PubMed ID: 23536552	2013
AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/Î²-catenin signaling pathway. Blood\| PubMed ID: 23645839	2013
Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chemistry & biology\| PubMed ID: 23706636	2013
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer. Cancer discovery\| PubMed ID: 23715154	2013
Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents. PloS one\| PubMed ID: 23894528	2013