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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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Journal (Immunology and Infection)
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An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization
Journal (Immunology and Infection)
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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Article DOI: 10.3791/50690
August 16th, 2013 •
1, 2
1Lurie Family Imaging Center, Dana-Farber Cancer Institute, Harvard Medical School, 2Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center

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Summary
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August 16th, 2013

We describe a non-invasive imaging method for distinguishing inflammatory stages. Systemic delivery of luminol reveals areas of acute inflammation dependent upon MPO activity in neutrophils. In contrast, injection of lucigenin allows for visualization of chronic inflammation dependent upon Phox activity in macrophages.

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