David R. Walt

Department of Chemistry, Tufts University

Affiliated withTufts University Wyss Institute at Harvard University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 4	2013
Publication title Cited by 2	2021

Other Publications

Article	Year
Aluminum surface corrosion and the mechanism of inhibitors using pH and metal ion selective imaging fiber bundles. Analytical chemistry\| PubMed ID: 11866069	2002
High-density fiber-optic genosensor microsphere array capable of zeptomole detection limits. Analytical chemistry\| PubMed ID: 11985315	2002
Fabrication of an optoelectrochemical microring array. Analytical chemistry\| PubMed ID: 12033265	2002
Optical imaging fiber-based single live cell arrays: a high-density cell assay platform. Analytical chemistry\| PubMed ID: 12141663	2002
Automatic decoding of sensor types within randomly ordered, high-density optical sensor arrays. Analytical and bioanalytical chemistry\| PubMed ID: 12194041	2002
Imaging optical sensor arrays. Current opinion in chemical biology\| PubMed ID: 12413555	2002
The use of optical fiber bundles combined with electrochemistry for chemical imaging. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 12619418	2003
Enhancing vapor sensor discrimination by mimicking a canine nasal cavity flow environment. Journal of the American Chemical Society\| PubMed ID: 12656583	2003
Optical imaging fiber-based live bacterial cell array biosensor. Analytical biochemistry\| PubMed ID: 12672418	2003
High-density, microsphere-based fiber optic DNA microarrays. Biosensors & bioelectronics\| PubMed ID: 12706560	2003
Fluorescence-based fibre optic arrays: a universal platform for sensing. Chemical Society reviews\| PubMed ID: 12875026	2003
Combinatorial decoding: an approach for universal DNA array fabrication. Journal of the American Chemical Society\| PubMed ID: 14599214	2003
Spatially resolved electrochemiluminescence on an array of electrode tips. Analytical chemistry\| PubMed ID: 14632040	2003
Information coding in artificial olfaction multisensor arrays. Analytical chemistry\| PubMed ID: 14632130	2003
Reversible ratiometric probe for quantitative DNA measurements. Analytical chemistry\| PubMed ID: 14961724	2004
Living bacterial cell array for genotoxin monitoring. Analytical chemistry\| PubMed ID: 15144203	2004
Optical fiber-based biosensors. Analytical and bioanalytical chemistry\| PubMed ID: 15221182	2004
Simultaneously monitoring gene expression kinetics and genetic noise in single cells by optical well arrays. Analytical chemistry\| PubMed ID: 15516119	2004
Array-based binary analysis for bacterial typing. Analytical chemistry\| PubMed ID: 15623311	2005
Chemistry. Miniature analytical methods for medical diagnostics. Science (New York, N.Y.)\| PubMed ID: 15821081	2005
Individual cell migration analysis using fiber-optic bundles. Analytical and bioanalytical chemistry\| PubMed ID: 15900449	2005
Personalized exposure assessment: promising approaches for human environmental health research. Environmental health perspectives\| PubMed ID: 16002370	2005
Detection of Salmonella spp. using microsphere-based, fiber-optic DNA microarrays. Analytical chemistry\| PubMed ID: 16053320	2005
Monitoring "promiscuous" drug effects on single cells of multiple cell types. Analytical biochemistry\| PubMed ID: 16099418	2005
Optical fiber-based sensors: application to chemical biology. Current opinion in chemical biology\| PubMed ID: 16125439	2005
Development of a microfluidic platform with an optical imaging microarray capable of attomolar target DNA detection. Analytical chemistry\| PubMed ID: 16131069	2005
Extending the longevity of fluorescence-based sensor arrays using adaptive exposure. Analytical chemistry\| PubMed ID: 16194073	2005
Detecting biological warfare agents. Emerging infectious diseases\| PubMed ID: 16318712	2005
Fiber-optic microsphere-based arrays for multiplexed biological warfare agent detection. Analytical chemistry\| PubMed ID: 16478092	2006
Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano letters\| PubMed ID: 16522055	2006
Microbead chemical switches: an approach to detection of reactive organophosphate chemical warfare agent vapors. Journal of the American Chemical Society\| PubMed ID: 16608338	2006
Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays. Journal of the American Chemical Society\| PubMed ID: 16683771	2006
Detecting oxygen consumption in the proximity of Saccharomyces cerevisiae cells using self-assembled fluorescent nanosensors. Biotechnology and bioengineering\| PubMed ID: 16878334	2007
Fiber-optic microarray for simultaneous detection of multiple harmful algal bloom species. Applied and environmental microbiology\| PubMed ID: 16957189	2006
Fiber-based single cell analysis of reporter gene expression in yeast two-hybrid systems. Analytical biochemistry\| PubMed ID: 17113561	2007
Fiber optic array biosensors. BioTechniques\| PubMed ID: 17140107	2006
Microsensor arrays for saliva diagnostics. Annals of the New York Academy of Sciences\| PubMed ID: 17435144	2007
Duplexed sandwich immunoassays on a fiber-optic microarray. Analytica chimica acta\| PubMed ID: 17723359	2006
Optical-fiber bundles. The FEBS journal\| PubMed ID: 17937772	2007
Stochastic inhibitor release and binding from single-enzyme molecules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17965235	2007
Multianalyte single-cell analysis with multiple cell lines using a fiber-optic array. Analytical chemistry\| PubMed ID: 17973503	2007
Very high density sensing arrays. Chemical reviews\| PubMed ID: 18229955	2008
Distinct and long-lived activity states of single enzyme molecules. Journal of the American Chemical Society\| PubMed ID: 18318491	2008
Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle. Clinical chemistry\| PubMed ID: 18676588	2008
Detection of single-molecule DNA hybridization using enzymatic amplification in an array of femtoliter-sized reaction vessels. Journal of the American Chemical Society\| PubMed ID: 18763768	2008
Fabrication and optical characterization of imaging fiber-based nanoarrays. Talanta\| PubMed ID: 18970195	2005
Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Analytical chemistry\| PubMed ID: 19192965	2009
DNA detection on ultrahigh-density optical fiber-based nanoarrays. Biosensors & bioelectronics\| PubMed ID: 19195871	2009
Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies. Journal of the American Chemical Society\| PubMed ID: 19338338	2009
Multiplexed sandwich immunoassays using electrochemiluminescence imaging resolved at the single bead level. Journal of the American Chemical Society\| PubMed ID: 19361216	2009
Infochemistry and infofuses for the chemical storage and transmission of coded information. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19470465	2009
Temporally resolved fluorescence spectroscopy of a microarray-based vapor sensing system. Analytical chemistry\| PubMed ID: 19518137	2009
Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay. Analytical chemistry\| PubMed ID: 19548682	2009
Design, implementation, and field testing of a portable fluorescence-based vapor sensor. Analytical chemistry\| PubMed ID: 19563211	2009
Chromatically resolved optical microscope (CROMoscope): a grating-based instrument for spectral imaging. Analytical chemistry\| PubMed ID: 19653690	2009
Intelligent medical diagnostics via molecular logic. Journal of the American Chemical Society\| PubMed ID: 19715272	2009
Ubiquitous sensors: when will they be here? ACS nano\| PubMed ID: 19856977	2009
Detection and classification of ignitable liquid residues using a fluorescence-based vapor-sensitive microsphere array. Journal of forensic sciences\| PubMed ID: 20002259	2010
Fibre optic microarrays. Chemical Society reviews\| PubMed ID: 20023835	2010
Note: Toward multiple addressable optical trapping. The Review of scientific instruments\| PubMed ID: 20192526	2010
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nature biotechnology\| PubMed ID: 20495550	2010
Multiplexed spectroscopic detections. Annual review of analytical chemistry (Palo Alto, Calif.)\| PubMed ID: 20636088	2008
Bead-based optical fiber arrays for artificial olfaction. Current opinion in chemical biology\| PubMed ID: 20655803	2010
Visualizing Fluorescence: Using a Homemade Fluorescence "Microscope" to View Latent Fingerprints on Paper. Journal of chemical education\| PubMed ID: 20852733	2010
Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 21057320	2011
Single cell time-resolved quorum responses reveal dependence on cell density and configuration. The Journal of biological chemistry\| PubMed ID: 21527637	2011
InfoBiology by printed arrays of microorganism colonies for timed and on-demand release of messages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21949364	2011
Oil-sealed femtoliter fiber-optic arrays for single molecule analysis. Lab on a chip\| PubMed ID: 22311152	2012
Optical methods for single molecule detection and analysis. Analytical chemistry\| PubMed ID: 23215010	2013
Dynamic microbead arrays for biosensing applications. Lab on a chip\| PubMed ID: 23615790	2013
Assessing the stochastic intermittency of single quantum dot luminescence for robust quantification of biomolecules. Analytical chemistry\| PubMed ID: 23631644	2013
Multiplexed salivary protein profiling for patients with respiratory diseases using fiber-optic bundles and fluorescent antibody-based microarrays. Analytical chemistry\| PubMed ID: 23972398	2013
Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma. PloS one\| PubMed ID: 24409298	2014
An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples. Lab on a chip\| PubMed ID: 24448498	2014
Observing single enzyme molecules interconvert between activity states upon heating. PloS one\| PubMed ID: 24465972	2014
Protein measurements in microwells. Lab on a chip\| PubMed ID: 24825470	2014
Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. Journal of the American Chemical Society\| PubMed ID: 25198059	2014
Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Nature nanotechnology\| PubMed ID: 25466541	2014
Genome-wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus biotype 3. PloS one\| PubMed ID: 25526263	2014
Stoichiometry of the α-complementation reaction of Escherichia coli β-galactosidase as revealed through single-molecule studies. Biochemistry\| PubMed ID: 25668156	2015
Single-molecule arrays for ultrasensitive detection of host immune response to dengue virus infection. Journal of clinical microbiology\| PubMed ID: 25694521	2015
Salivary diagnostics using a portable point-of-service platform: a review. Clinical therapeutics\| PubMed ID: 25732629	2015
Ultrasensitive Detection of Ricin Toxin in Multiple Sample Matrixes Using Single-Domain Antibodies. Analytical chemistry\| PubMed ID: 26001138	2015
Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring. Scientific reports\| PubMed ID: 26052106	2015
Correlations of salivary biomarkers with clinical assessments in patients with cystic fibrosis. PloS one\| PubMed ID: 26258476	2015
Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples. The Analyst\| PubMed ID: 26270328	2015
Protein Counting in Single Cancer Cells. Analytical chemistry\| PubMed ID: 26813414	2016
Incorporation of Slow Off-Rate Modified Aptamers Reagents in Single Molecule Array Assays for Cytokine Detection with Ultrahigh Sensitivity. Analytical chemistry\| PubMed ID: 27529794	2016
Using Antigen-antibody Binding Kinetic Parameters to Understand Single-Molecule Array Immunoassay Performance. Analytical chemistry\| PubMed ID: 27779850	2016
Personal microbiomes and next-generation sequencing for laboratory-based education. FEMS microbiology letters\| PubMed ID: 27856569	2016
Single-Molecule Arrays for Protein and Nucleic Acid Analysis. Annual review of analytical chemistry (Palo Alto, Calif.)\| PubMed ID: 28301748	2017
Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom. CBE life sciences education\| PubMed ID: 28408407	2017
Digital direct detection of microRNAs using single molecule arrays. Nucleic acids research\| PubMed ID: 28637221	2017
Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomarkers in medicine\| PubMed ID: 28644039	2017
Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variations between Individuals. The American journal of pathology\| PubMed ID: 28919109	2017
Single Molecule Arrays for ultra-sensitive detection of rat cytokines in serum. Journal of immunological methods\| PubMed ID: 29037955	2018
Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis. Chemical science\| PubMed ID: 29142687	2015
Development of a Rapid Salivary Proteomic Platform for Oral Feeding Readiness in the Preterm Newborn. Frontiers in pediatrics\| PubMed ID: 29312906	2017
Bottom-up single-molecule strategy for understanding subunit function of tetrameric β-galactosidase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30061400	2018
Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease. Analytical biochemistry\| PubMed ID: 30267709	2019
Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines. Clinical biochemistry\| PubMed ID: 30633878	2019
Protein Detection by Counting Molecules. Clinical chemistry\| PubMed ID: 30692115	2019
A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough. Science translational medicine\| PubMed ID: 31645455	2019
Evaluation of two commercial and two non-commercial immunoassays for the detection of prior infection to SARS-CoV-2. medRxiv : the preprint server for health sciences\| PubMed ID: 32607518	2020
Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clinical chemistry\| PubMed ID: 32897389	2020
Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19. Nature biomedical engineering\| PubMed ID: 32948854	2020
Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC. Journal for immunotherapy of cancer\| PubMed ID: 33020238	2020