Stephen C Cunnane

Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2013

Other Publications

Article	Year
Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology\| PubMed ID: 22855869	2012
The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study. Brain research\| PubMed ID: 23063891	2012
Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet. Clinical chemistry\| PubMed ID: 11751546	2002
Arachidonate metabolism in neonates. Pediatric research\| PubMed ID: 11861928	2002
Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia\| PubMed ID: 11879380	2002
Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology\| PubMed ID: 11923081	2002
Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized co... The American journal of clinical nutrition\| PubMed ID: 11976156	2002
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. The American journal of clinical nutrition\| PubMed ID: 12081817	2002
Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. The American journal of clinical nutrition\| PubMed ID: 12145008	2002
Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. The American journal of clinical nutrition\| PubMed ID: 12540417	2003
Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. Journal of lipid research\| PubMed ID: 12576513	2003
Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats. Lipids\| PubMed ID: 12733752	2003
Why is carbon from some polyunsaturates extensively recycled into lipid synthesis? Lipids\| PubMed ID: 12848297	2003
Survival of the fattest: fat babies were the key to evolution of the large human brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology\| PubMed ID: 14527626	2003
Problems with essential fatty acids: time for a new paradigm? Progress in lipid research\| PubMed ID: 14559071	2003
Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet. Lipids\| PubMed ID: 14669969	2003
Metabolism of polyunsaturated fatty acids and ketogenesis: an emerging connection. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 14769482	2004
Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle. Lipids\| PubMed ID: 14870924	2003
Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols. Journal of lipid research\| PubMed ID: 15314096	2004
Claims to identify detrimental effects of the ketogenic diet (KD) on cognitive function in rats. Pediatric research\| PubMed ID: 15319466	2004
Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant. Immunology letters\| PubMed ID: 15325802	2004
Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects. Lipids\| PubMed ID: 15884765	2005
Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain. The American journal of clinical nutrition\| PubMed ID: 16087997	2005
Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. Metabolism: clinical and experimental\| PubMed ID: 16125522	2005
Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 16183255	2006
Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. Pediatric research\| PubMed ID: 16326997	2006
[Survival of the fattest: the key to human brain evolution]. Médecine sciences : M/S\| PubMed ID: 16828044	2006
Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 16829066	2006
Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. Lipids\| PubMed ID: 17180881	2006
Comparison of composition and absorption of sugarcane policosanols. The British journal of nutrition\| PubMed ID: 17298709	2007
alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. The American journal of clinical nutrition\| PubMed ID: 17344517	2007
Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane. The British journal of nutrition\| PubMed ID: 17408531	2007
Biosynthetic production of universally (13)C-labelled polyunsaturated fatty acids as reference materials for natural health product research. Analytical and bioanalytical chemistry\| PubMed ID: 17486321	2007
Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine\| PubMed ID: 17544283	2007
Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal. American journal of human biology : the official journal of the Human Biology Council\| PubMed ID: 17546620	2007
Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme\| PubMed ID: 17622276	2007
Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 17981439	2008
Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 18036804	2007
Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 18195289	2008
An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development? The British journal of nutrition\| PubMed ID: 18307824	2008
[11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 18454299	2008
Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. Journal of the American College of Nutrition\| PubMed ID: 18460483	2008
Conjugated linoleic acids: why the discrepancy between animal and human studies? Nutrition reviews\| PubMed ID: 18667017	2008
Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. Lipids\| PubMed ID: 18795357	2008
Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias. Journal of the American College of Nutrition\| PubMed ID: 18838524	2008
Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 19036560	2009
Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate. Epilepsia\| PubMed ID: 19049595	2008
Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids. The Journal of nutrition\| PubMed ID: 19244379	2009
alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 19269799	2009
n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. Public health nutrition\| PubMed ID: 19433004	2010
Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men. The British journal of nutrition\| PubMed ID: 19828088	2009
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring. Endocrinology\| PubMed ID: 20160134	2010
Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20404010	2010
Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain. European journal of nuclear medicine and molecular imaging\| PubMed ID: 20437239	2010
Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. PloS one\| PubMed ID: 20532041	2010
Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly. Nutrition & metabolism\| PubMed ID: 21272363	2011
n-3 fatty acids and cardiovascular events. The New England journal of medicine\| PubMed ID: 21366485	2011
Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats. Nutritional neuroscience\| PubMed ID: 21605500	2011
Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 22466064	2012
Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 22575581	2013
n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal act... Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 22579067	2012
Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. The American journal of clinical nutrition\| PubMed ID: 23221573	2013
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 23274095	2013
Thyroid function and cognition in the euthyroid elderly: A case-control study embedded in Quebec longitudinal study - NuAge. Psychoneuroendocrinology\| PubMed ID: 23507188	2013
Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutrition research (New York, N.Y.)\| PubMed ID: 23684438	2013
Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. Journal of lipid research\| PubMed ID: 23801662	2013
Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet. Neurochemistry international\| PubMed ID: 23974047	2013
Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy. PloS one\| PubMed ID: 24098376	2013
Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. The Proceedings of the Nutrition Society\| PubMed ID: 24103099	2013