Daniel E. Kaufmann

The Ragon Institute of MGH, MIT and Harvard

Affiliated withThe Ragon Institute of MGH, MIT and Harvard Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM)

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2013

Other Publications

Article	Year
The value of preserving HIV-specific immune responses. Journal of HIV therapy\| PubMed ID: 12840711	2003
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. Journal of virology\| PubMed ID: 15078927	2004
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells. AIDS research and human retroviruses\| PubMed ID: 15117455	2004
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells. Journal of virology\| PubMed ID: 15280492	2004
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. The Journal of experimental medicine\| PubMed ID: 15381726	2004
Limited durability of viral control following treated acute HIV infection. PLoS medicine\| PubMed ID: 15526059	2004
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection. Blood\| PubMed ID: 15905189	2005
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. Journal of virology\| PubMed ID: 16227247	2005
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef. Blood\| PubMed ID: 16249391	2006
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature\| PubMed ID: 16921384	2006
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 in... Journal of virology\| PubMed ID: 17005693	2006
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection. PLoS medicine\| PubMed ID: 17194190	2006
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory... Journal of virology\| PubMed ID: 17329344	2007
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nature immunology\| PubMed ID: 17906628	2007
Increased sequence diversity coverage improves detection of HIV-specific T cell responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17982054	2007
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. The Journal of infectious diseases\| PubMed ID: 18275276	2008
In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection. PloS one\| PubMed ID: 19165342	2009
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection. PloS one\| PubMed ID: 19352428	2009
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood\| PubMed ID: 19365081	2009
Treatment interruption to boost specific HIV immunity in acute infection. Current opinion in HIV and AIDS\| PubMed ID: 19372861	2007
Programmed death-1 as a factor in immune exhaustion and activation in HIV infection. Current opinion in HIV and AIDS\| PubMed ID: 19372991	2008
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19414738	2009
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19949078	2010
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences. The Journal of experimental medicine\| PubMed ID: 20065065	2010
Impaired replication capacity of acute/early viruses in persons who become HIV controllers. Journal of virology\| PubMed ID: 20504921	2010
Protective andÂ detrimental roles ofÂ IL-10 inÂ HIV pathogenesis. European cytokine network\| PubMed ID: 20732847	2010
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nature medicine\| PubMed ID: 20890291	2010
Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. Journal of leukocyte biology\| PubMed ID: 21097698	2011
Ets-1 maintains IL-7 receptor expression in peripheral T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21148801	2011
Epithelial adhesion molecules can inhibit HIV-1-specific CD8âº T-cell functions. Blood\| PubMed ID: 21403126	2011
HIV-specific CD4 T cells and immune control of viral replication. Current opinion in HIV and AIDS\| PubMed ID: 21502921	2011
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood\| PubMed ID: 21652684	2011
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. Journal of virology\| PubMed ID: 21752903	2011
HIV controllers: a multifactorial phenotype of spontaneous viral suppression. Clinical immunology (Orlando, Fla.)\| PubMed ID: 21865089	2011
Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 22100578	2012
Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report. Stem cells international\| PubMed ID: 22190964	2011
Role of PD-1 in HIV pathogenesis and as target for therapy. Current HIV/AIDS reports\| PubMed ID: 22198819	2012
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. The Journal of infectious diseases\| PubMed ID: 22427677	2012
CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes. Journal of virology\| PubMed ID: 22496237	2012
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nature immunology\| PubMed ID: 22683743	2012
A Blueprint for HIV Vaccine Discovery. Cell host & microbe\| PubMed ID: 23084910	2012
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood\| PubMed ID: 23233659	2013
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23772031	2013
Simultaneous TCR and CD244 Signals Induce Dynamic Downmodulation of CD244 on Human Antiviral T Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23913963	2013