Birgitta R. Knudsen Department of Molecular Biology and Genetics Aarhus University Biography Publications Institution JoVE Articles Birgitta R. Knudsen has not added a biography. If you are Birgitta R. Knudsen and would like to personalize this page please email our Author Liaison for assistance. Publications Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts Sensors (Basel, Switzerland). Oct, 2022 | Pubmed ID: 36298113 Topoisomerase 1 Inhibits MYC Promoter Activity by Inducing G-quadruplex Formation Nucleic Acids Research. Jun, 2022 | Pubmed ID: 35687110 Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX Cells. Apr, 2022 | Pubmed ID: 35563813 TDP1 and TOP1 As Targets in Anticancer Treatment of NSCLC: Activity and Protein Level in Normal and Tumor Tissue from 150 NSCLC Patients Correlated to Clinical Data Lung Cancer (Amsterdam, Netherlands). Feb, 2022 | Pubmed ID: 34974222 Synthesis of Hybrid Phosphorated Indenoquinolines and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferative Agents Bioorganic & Medicinal Chemistry Letters. Feb, 2022 | Pubmed ID: 34952177 Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1 Pharmaceutics. Aug, 2021 | Pubmed ID: 34452216 Hybrid Quinolinyl Phosphonates As Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation Against Topoisomerase 1B (TOP1B) Pharmaceuticals (Basel, Switzerland). Aug, 2021 | Pubmed ID: 34451880 A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors Sensors (Basel, Switzerland). Jul, 2021 | Pubmed ID: 34300575 Fused Chromeno and Quinolino[1,8]naphthyridines: Synthesis and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferative Agents Bioorganic & Medicinal Chemistry. Jun, 2021 | Pubmed ID: 33962152 Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities Cancers. May, 2020 | Pubmed ID: 32423158 DNA Flowerstructure Co-localizes with Human Pathogens in Infected Macrophages Nucleic Acids Research. Jun, 2020 | Pubmed ID: 32402089 Synthesis of Novel Hybrid Quinolino[4,3-b][1,5]naphthyridines and Quinolino[4,3-b][1,5]naphthyridin-6(5H)-one Derivatives and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferatives European Journal of Medicinal Chemistry. Jun, 2020 | Pubmed ID: 32279049 Topoisomerase I Activity and Sensitivity to Camptothecin in Breast Cancer-derived Cells: a Comparative Study BMC Cancer. Nov, 2019 | Pubmed ID: 31783818 Enzymatic Activity in Single Cells Methods in Enzymology. 2019 | Pubmed ID: 31668235 A New DNA Sensor System for Specific and Quantitative Detection of Mycobacteria Nanoscale. Jan, 2019 | Pubmed ID: 30556557 Detection of the Malaria Causing Plasmodium Parasite in Saliva from Infected Patients Using Topoisomerase I Activity As a Biomarker Scientific Reports. Mar, 2018 | Pubmed ID: 29515150 Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5 Cancer Genomics & Proteomics. 2018 | Pubmed ID: 29496689 On-slide Detection of Enzymatic Activities in Selected Single Cells Nanoscale. Sep, 2017 | Pubmed ID: 28872165 Interlinked DNA Nano-circles for Measuring Topoisomerase II Activity at the Level of Single Decatenation Events Nucleic Acids Research. Jul, 2017 | Pubmed ID: 28541438 The Effects of Dithiothreitol on DNA Sensors (Basel, Switzerland). May, 2017 | Pubmed ID: 28538659 Advantages of an Optical Nanosensor System for the Mechanistic Analysis of a Novel Topoisomerase I Targeting Drug: a Case Study Nanoscale. Feb, 2017 | Pubmed ID: 28094391 Novel DNA Sensor System for Highly Sensitive and Quantitative Retrovirus Detection Using Virus Encoded Integrase As a Biomarker Nanoscale. Jan, 2017 | Pubmed ID: 27934981 Optimized Detection of Plasmodium Falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons Sensors (Basel, Switzerland). Nov, 2016 | Pubmed ID: 27854277 DNA Hairpins Promote Temperature Controlled Cargo Encapsulation in a Truncated Octahedral Nanocage Structure Family Nanoscale. Jul, 2016 | Pubmed ID: 27341703 Characterization of DNA Topoisomerase I in Three SN-38 Resistant Human Colon Cancer Cell Lines Reveals a New Pair of Resistance-associated Mutations Journal of Experimental & Clinical Cancer Research : CR. Mar, 2016 | Pubmed ID: 27029323 Synthesis and Biological Evaluation of Indeno[1,5]naphthyridines As Topoisomerase I (TopI) Inhibitors with Antiproliferative Activity European Journal of Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27017547 Molecular Characterization of Irinotecan (SN-38) Resistant Human Breast Cancer Cell Lines BMC Cancer. Jan, 2016 | Pubmed ID: 26801902 Specific Detection of the Cleavage Activity of Mycobacterial Enzymes Using a Quantum Dot Based DNA Nanosensor Nanoscale. Jan, 2016 | Pubmed ID: 26616006 Microfluidics-Enabled Enzyme Activity Measurement in Single Cells Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 26542724 Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene ACS Nano. Nov, 2015 | Pubmed ID: 26445172 Correlation Between Topoisomerase I and Tyrosyl-DNA Phosphodiesterase 1 Activities in Non-small Cell Lung Cancer Tissue Experimental and Molecular Pathology. Aug, 2015 | Pubmed ID: 25987486 Real-time Investigation of Human Topoisomerase I Reaction Kinetics Using an Optical Sensor: a Fast Method for Drug Screening and Determination of Active Enzyme Concentrations Nanoscale. Jun, 2015 | Pubmed ID: 25963854 NanoCluster Beacons As Reporter Probes in Rolling Circle Enhanced Enzyme Activity Detection Nanoscale. May, 2015 | Pubmed ID: 25901841 Decreased Camptothecin Sensitivity of the Stem-cell-like Fraction of Caco2 Cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I PloS One. 2014 | Pubmed ID: 24960044 Synthesis of Fluorosurfactants for Emulsion-based Biological Applications ACS Nano. Apr, 2014 | Pubmed ID: 24646088 Rolling Circle Amplification-based Detection of Human Topoisomerase I Activity on Magnetic Beads Analytical Biochemistry. Apr, 2014 | Pubmed ID: 24525043 Topoisomerase I As a Biomarker: Detection of Activity at the Single Molecule Level Sensors (Basel, Switzerland). Jan, 2014 | Pubmed ID: 24434877 Real-time Detection of TDP1 Activity Using a Fluorophore-quencher Coupled DNA-biosensor Biosensors & Bioelectronics. Oct, 2013 | Pubmed ID: 23693093 Quantum Dot-based Nanosensors for Diagnosis Via Enzyme Activity Measurement Expert Review of Molecular Diagnostics. May, 2013 | Pubmed ID: 23638819 DNA-based Sensor for Real-time Measurement of the Enzymatic Activity of Human Topoisomerase I Sensors (Basel, Switzerland). Mar, 2013 | Pubmed ID: 23529147 Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-causing Plasmodium Parasites Based on Enzyme Activity Measurement ACS Nano. Dec, 2012 | Pubmed ID: 23121492 Microfluidics-mediated Isothermal Detection of Enzyme Activity at the Single Molecule Level Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. Aug, 2011 | Pubmed ID: 22255034 Peptide Inhibition of Topoisomerase IB from Plasmodium Falciparum Molecular Biology International. 2011 | Pubmed ID: 22091414 Detection of Single Enzymatic Events in Rare or Single Cells Using Microfluidics ACS Nano. Oct, 2011 | Pubmed ID: 21936557 Strategies for Highly Sensitive Biomarker Detection by Rolling Circle Amplification of Signals from Nucleic Acid Composed Sensors Integrative Biology : Quantitative Biosciences from Nano to Macro. Oct, 2011 | Pubmed ID: 21927767 The Geometry of DNA Supercoils Modulates the DNA Cleavage Activity of Human Topoisomerase I Nucleic Acids Research. Feb, 2011 | Pubmed ID: 20855291 Topoisomerase I Deficiency Results in Chromosomal Alterations in Cervical Cancer Cells Anticancer Research. Sep, 2010 | Pubmed ID: 20944095 Multiplexed Detection of Site Specific Recombinase and DNA Topoisomerase Activities at the Single Molecule Level ACS Nano. Dec, 2009 | Pubmed ID: 19950974 Single-molecule Detection of Human Topoisomerase I Cleavage-ligation Activity ACS Nano. Jan, 2009 | Pubmed ID: 19206270 Tryptophane-205 of Human Topoisomerase I is Essential for Camptothecin Inhibition of Negative but Not Positive Supercoil Removal Nucleic Acids Research. 2007 | Pubmed ID: 17827209 Dynamics of Human DNA Topoisomerases IIalpha and IIbeta in Living Cells The Journal of Cell Biology. Apr, 2002 | Pubmed ID: 11927602 Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples Josephine Geertsen Keller1,2, Karol Mizielinski3, Kamilla Vandsø Petersen1,2, Magnus Stougaard2,3,4, Birgitta R. Knudsen1,3, Cinzia Tesauro3 1Department of Molecular Biology and Genetics, Aarhus University, 2Department of Clinical Medicine, Aarhus University, 3VPCIR Biosciences ApS, 4Department of Pathology, Aarhus University Hospital JoVE 64484 Cancer Research
Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples Josephine Geertsen Keller1,2, Karol Mizielinski3, Kamilla Vandsø Petersen1,2, Magnus Stougaard2,3,4, Birgitta R. Knudsen1,3, Cinzia Tesauro3 1Department of Molecular Biology and Genetics, Aarhus University, 2Department of Clinical Medicine, Aarhus University, 3VPCIR Biosciences ApS, 4Department of Pathology, Aarhus University Hospital JoVE 64484 Cancer Research
