Marina K. Kuimova Department of Chemistry Imperial College London Biography Publications Institution JoVE Articles Marina K. Kuimova has not added a biography. If you are Marina K. Kuimova and would like to personalize this page please email our Author Liaison for assistance. Publications Cyclopropyl Substituents Transform the Viscosity-Sensitive BODIPY Molecular Rotor into a Temperature Sensor ACS Sensors. 06, 2021 | Pubmed ID: 34060823 Metal Complexes As Optical Probes for DNA Sensing and Imaging Current Opinion in Chemical Biology. 04, 2021 | Pubmed ID: 33784589 Rotaxanes As Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule* Angewandte Chemie (International Ed. in English). 05, 2021 | Pubmed ID: 33577711 Visualising G-quadruplex DNA Dynamics in Live Cells by Fluorescence Lifetime Imaging Microscopy Nature Communications. 01, 2021 | Pubmed ID: 33420085 Assessing The Key Photophysical Properties of Triangulenium Dyes for DNA Binding by Alteration of the Fluorescent Core Chemistry (Weinheim an Der Bergstrasse, Germany). Feb, 2021 | Pubmed ID: 33105523 Imaging Non-classical Mechanical Responses of Lipid Membranes Using Molecular Rotors Chemical Science. Dec, 2020 | Pubmed ID: 34164028 Mapping Cisplatin-induced Viscosity Alterations in Cancer Cells Using Molecular Rotor and Fluorescence Lifetime Imaging Microscopy Journal of Biomedical Optics. 12, 2020 | Pubmed ID: 33331150 Transcutaneous Fluorescence Spectroscopy As a Tool for Non-invasive Monitoring of Gut Function: First Clinical Experiences Scientific Reports. 09, 2020 | Pubmed ID: 32999336 The Effect of Structural Heterogeneity Upon the Microviscosity of Ionic Liquids Chemical Science. Jun, 2020 | Pubmed ID: 32874514 Unravelling the Enzymatic Degradation Mechanism of Supramolecular Peptide Nanofibers and Its Correlation with Their Internal Viscosity Nano Letters. 10, 2020 | Pubmed ID: 32866016 Monitoring Membrane Viscosity in Differentiating Stem Cells Using BODIPY-based Molecular Rotors and FLIM Scientific Reports. 08, 2020 | Pubmed ID: 32820221 Rapid Formation of Human Immunodeficiency Virus-like Particles Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32817566 Simultaneous Detection of Carbon Monoxide and Viscosity Changes in Cells Angewandte Chemie (International Ed. in English). 11, 2020 | Pubmed ID: 32686308 Linker Length Affects Photostability of Protein-targeted Sensor of Cellular Microviscosity Methods and Applications in Fluorescence. Oct, 2019 | Pubmed ID: 31557750 Microscopic Viscosity of Neuronal Plasma Membranes Measured Using Fluorescent Molecular Rotors: Effects of Oxidative Stress and Neuroprotection ACS Applied Materials & Interfaces. Oct, 2019 | Pubmed ID: 31513373 Measuring Intracellular Viscosity in Conditions of Hypergravity Biophysical Journal. 05, 2019 | Pubmed ID: 31053255 Rapid Fragmentation During Seeded Lysozyme Aggregation Revealed at the Single Molecule Level Analytical Chemistry. 05, 2019 | Pubmed ID: 30999745 Molecular Rotors Report on Changes in Live Cell Plasma Membrane Microviscosity Upon Interaction with Beta-amyloid Aggregates Soft Matter. Nov, 2018 | Pubmed ID: 30427370 An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles ACS Nano. 05, 2018 | Pubmed ID: 29648785 Live Cell Imaging of Viscosity in 3D Tumour Cell Models Advances in Experimental Medicine and Biology. 2017 | Pubmed ID: 29080136 Exploring Viscosity, Polarity and Temperature Sensitivity of BODIPY-based Molecular Rotors Physical Chemistry Chemical Physics : PCCP. Sep, 2017 | Pubmed ID: 28718466 Probing Supramolecular Protein Assembly Using Covalently Attached Fluorescent Molecular Rotors Biomaterials. Sep, 2017 | Pubmed ID: 28622603 Visualising the Membrane Viscosity of Porcine Eye Lens Cells Using Molecular Rotors Chemical Science. May, 2017 | Pubmed ID: 28580097 Tuning the Sensitivity of Fluorescent Porphyrin Dimers to Viscosity and Temperature Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2017 | Pubmed ID: 28480989 Imaging Tumor Microscopic Viscosity in Vivo Using Molecular Rotors Scientific Reports. 01, 2017 | Pubmed ID: 28134273 Modulation of the Molecular Arrangement in Artificial and Biological Membranes by Phospholipid-shelled Microbubbles Biomaterials. 01, 2017 | Pubmed ID: 27814482 Direct Imaging of Changes in Aerosol Particle Viscosity Upon Hydration and Chemical Aging Chemical Science. Feb, 2016 | Pubmed ID: 29910892 Dynamic Viscosity Mapping of the Oxidation of Squalene Aerosol Particles Physical Chemistry Chemical Physics : PCCP. Nov, 2016 | Pubmed ID: 27781216 Imaging Plasma Membrane Phase Behaviour in Live Cells Using a Thiophene-based Molecular Rotor Chemical Communications (Cambridge, England). Nov, 2016 | Pubmed ID: 27775102 Measuring the Viscosity of the Escherichia Coli Plasma Membrane Using Molecular Rotors Biophysical Journal. Oct, 2016 | Pubmed ID: 27705775 A Molecular Rotor That Measures Dynamic Changes of Lipid Bilayer Viscosity Caused by Oxidative Stress Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2016 | Pubmed ID: 27487026 Effect of Ethanol Perturbation on Viscosity and Permeability of an Inner Membrane in Bacillus Subtilis Spores Biochimica Et Biophysica Acta. 09, 2016 | Pubmed ID: 27267704 Trianguleniums As Optical Probes for G-Quadruplexes: A Photophysical, Electrochemical, and Computational Study Chemistry (Weinheim an Der Bergstrasse, Germany). Mar, 2016 | Pubmed ID: 26880483 Dual Use of Porphyrazines As Sensitizers and Viscosity Markers in Photodynamic Therapy Journal of Materials Chemistry. B. Feb, 2015 | Pubmed ID: 32261987 Dual Wavelength Asymmetric Photochemical Synthesis with Circularly Polarized Light Chemical Science. Jul, 2015 | Pubmed ID: 29218156 Unravelling the Effect of Temperature on Viscosity-sensitive Fluorescent Molecular Rotors Chemical Science. Oct, 2015 | Pubmed ID: 28791085 The Interactions Between a Small Molecule and G-quadruplexes Are Visualized by Fluorescence Lifetime Imaging Microscopy Nature Communications. Sep, 2015 | Pubmed ID: 26350962 Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation The Journal of Physical Chemistry. B. Aug, 2015 | Pubmed ID: 26192338 Imaging Phase Separation in Model Lipid Membranes Through the Use of BODIPY Based Molecular Rotors Physical Chemistry Chemical Physics : PCCP. Jul, 2015 | Pubmed ID: 26104504 Dual Mode Quantitative Imaging of Microscopic Viscosity Using a Conjugated Porphyrin Dimer Physical Chemistry Chemical Physics : PCCP. Mar, 2015 | Pubmed ID: 25706402 Fatty Acid Membrane Assembly on Coacervate Microdroplets As a Step Towards a Hybrid Protocell Model Nature Chemistry. Jun, 2014 | Pubmed ID: 24848239 A Molecular Rotor for Measuring Viscosity in Plasma Membranes of Live Cells Chemical Communications (Cambridge, England). May, 2014 | Pubmed ID: 24266030 Fluorescent Lifetime Imaging of Atmospheric Aerosols: a Direct Probe of Aerosol Viscosity Faraday Discussions. 2013 | Pubmed ID: 24601010 Molecular Rheometry: Direct Determination of Viscosity in Lo and Ld Lipid Phases Via Fluorescence Lifetime Imaging Physical Chemistry Chemical Physics : PCCP. Sep, 2013 | Pubmed ID: 23912893 Mapping Microbubble Viscosity Using Fluorescence Lifetime Imaging of Molecular Rotors Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23690599 A Cyclometallated Platinum Complex As a Selective Optical Switch for Quadruplex DNA Chemistry (Weinheim an Der Bergstrasse, Germany). Dec, 2012 | Pubmed ID: 23165895 Mapping Viscosity in Cells Using Molecular Rotors Physical Chemistry Chemical Physics : PCCP. Oct, 2012 | Pubmed ID: 22806312 Novel Photosensitisers Derived from Pyropheophorbide-a: Uptake by Cells and Photodynamic Efficiency in Vitro Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Jul, 2010 | Pubmed ID: 20532306 Imaging Intracellular Viscosity of a Single Cell During Photoinduced Cell Death Nature Chemistry. Apr, 2009 | Pubmed ID: 21378803 Intramolecular Rotation in a Porphyrin Dimer Controls Singlet Oxygen Production Journal of the American Chemical Society. Jun, 2009 | Pubmed ID: 19507899 Photophysical Properties and Intracellular Imaging of Water-soluble Porphyrin Dimers for Two-photon Excited Photodynamic Therapy Organic & Biomolecular Chemistry. Mar, 2009 | Pubmed ID: 19225671 Chemical Imaging of Live Cancer Cells in the Natural Aqueous Environment Applied Spectroscopy. Feb, 2009 | Pubmed ID: 19215645 Singlet Oxygen in a Cell: Spatially Dependent Lifetimes and Quenching Rate Constants Journal of the American Chemical Society. Jan, 2009 | Pubmed ID: 19128181 Molecular Rotor Measures Viscosity of Live Cells Via Fluorescence Lifetime Imaging Journal of the American Chemical Society. May, 2008 | Pubmed ID: 18457396 Fluorescence Characterisation of Multiply-loaded Anti-HER2 Single Chain Fv-photosensitizer Conjugates Suitable for Photodynamic Therapy Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Sep, 2007 | Pubmed ID: 17721591 Determination of the Triplet State Energies of a Series of Conjugated Porphyrin Oligomers Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Jun, 2007 | Pubmed ID: 17549270 Probing Metabolism and Viscosity of Cancer Cells using Fluorescence Lifetime Imaging Microscopy Liubov Shimolina1, Maria Lukina1, Vladislav Shcheslavskiy1,2, Vadim Elagin1, Varvara Dudenkova1, Nadezhda Ignatova1, Marina K. Kuimova3, Marina Shirmanova1 1Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 2Becker & Hickl GmbH, 3Department of Chemistry, Imperial College London JoVE 62708 Cancer Research
Probing Metabolism and Viscosity of Cancer Cells using Fluorescence Lifetime Imaging Microscopy Liubov Shimolina1, Maria Lukina1, Vladislav Shcheslavskiy1,2, Vadim Elagin1, Varvara Dudenkova1, Nadezhda Ignatova1, Marina K. Kuimova3, Marina Shirmanova1 1Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 2Becker & Hickl GmbH, 3Department of Chemistry, Imperial College London JoVE 62708 Cancer Research