Diabetic Vascular Disease
Diabetic Vascular Disease - Related Videos
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
09:06
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
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Cited by 7 •
2012
We describe a technique in which a section of the abdominal aorta from a mouse is transplanted orthotopically to just below the renal arteries in an allogeneic or syngeneic recipient. This technique can be useful in studies in which transplantation of large arteries of uniform size is deemed advantageous.
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Cited by 2 •
2007
10:43
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Cited by 98 •
2007
Our protocol was developed to cleanly and easily deliver islets or cells under the kidney capsule of mice. Cells are concentrated into pellets in the final tubing used for transplanting the cells under the kidney capsule. The ease of this technique reduces stress to the cells and the mouse.
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Cited by 2 •
2022
In line with the urgent need for screening for type 1 diabetes, celiac disease, and coronavirus disease 2019, we developed a high throughput 6-Plex electrochemiluminescence assay to simultaneously detect all four islet autoantibodies, tissue transglutaminase autoantibodies, and antibodies to the receptor binding domain of severe acute respiratory syndrome coronavirus 2.
FAQs
Persistent high glucose drives several linked disturbances rather than a single vascular defect. Advanced glycation end products accumulate, while oxidative stress and inflammation disrupt endothelial function. These changes interfere with nitric oxide signaling and vascular remodeling, altering how vessels regulate perfusion and repair. Bioengineered models can isolate these interacting processes under controlled diabetic conditions.
Reduced nitric oxide signaling matters because it is one of the endothelial changes associated with diabetic vascular injury. Studying this pathway alongside oxidative stress and inflammation helps distinguish a direct signaling defect from broader remodeling changes. That distinction can guide drug testing in engineered systems designed to reproduce diabetic vascular conditions.
Impaired healing is linked to the disease's combined effects on perfusion and vascular regulation. Ischemia limits blood supply, while endothelial dysfunction and disrupted remodeling reduce the vessel responses needed during tissue repair. Bioengineering models can reproduce these conditions to study why repair fails and evaluate strategies for restoring perfusion.
Engineered blood vessels provide a controllable setting for recreating diabetic conditions and examining their effects on vascular behavior. Within bioengineering studies, they can support investigation of disease mechanisms, drug testing, and assessment of biomaterials. Their value is experimental control: researchers can compare responses under defined conditions rather than relying only on affected tissues.
Organ-on-chip systems and vascularized tissue models extend the analysis beyond isolated blood vessels by placing vascular behavior within engineered tissue contexts. In diabetic vascular disease research, these platforms help recreate disease conditions, investigate organ- or wound-related consequences, and test candidate drugs or biomaterials. This connects vascular mechanisms with tissue-level outcomes.
Bioengineering platforms are especially relevant when the goal is to restore perfusion rather than only describe vascular injury. They support evaluation of approaches for diabetic wounds, cardiovascular complications, and tissue regeneration, while also enabling drug and biomaterial testing. The models connect mechanistic findings with therapeutic design across several consequences of diabetes-related vascular dysfunction.