Corneoscleral Shell
Corneoscleral Shell - Related Videos
03:17
Corneoscleral Button Isolation: A Surgical Procedure to Obtain Corneoscleral Button from Porcine Eye
0 Views •
2025
In this video, we show a procedure to surgically isolate the corneoscleral button to generate an ex vivo porcine cornea model. The model is helpful for histological, pathological, and pharmacological studies due to its similarity to the human eye.
05:00
Porcine Ex vivo Cornea Model of Bacterial Keratitis: A Technique to Establish Bacterial Infection in Corneal Epithelial Cells
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2025
This video describes a protocol to set up an ex vivo model for bacterial keratitis using a corneoscleral button dissected from the porcine eye. Inoculated bacteria traverse the corneal epithelial incisions to invade the underlying stroma and establish an infection within the corneal tissues that mimic the in vivo infection.
05:21
Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses
0 Views •
Cited by 9 •
2019
Here we present a protocol which characterizes the sense of agency developed over the control of sensate virtual or robotic prosthetic hands. Psychophysical questionnaires are employed to capture the explicit experience of agency, and time interval estimates (intentional binding) are employed to implicitly measure the sense of agency.
03:24
Anterior Eye Segment Dissection: A Method to Isolate Cornea Bearing Anterior Segment from Porcine Eye
0 Views •
2025
In this video, we demonstrate the dissection of the cornea-bearing anterior segment of the porcine eye. The isolated segment can be used for organ culturing to study the pathophysiology of eye disorders.
04:11
Laser-assisted Selective Ablation of Porcine Corneal Endothelial Cells: A Technique to Induce Focused Porcine Corneal Endothelial Injury for Ex Vivo Studies
0 Views •
2025
This video demonstrates a non-invasive laser-assisted procedure to selectively damage the corneal endothelial cells in the porcine eye. The developed ex vivo model of endothelial cell damage can be used to study diseases of the corneal endothelium.
FAQs
Layered, directionally organized collagen causes the tissue to respond differently depending on loading direction, rather than behaving as a uniform material. This anisotropy is important because the shell must distribute intraocular-pressure loads while preserving the cornea’s precise refractive shape. Bioengineers therefore treat collagen organization as a structural variable when linking tissue deformation to ocular function.
Hydration and regional material differences jointly influence how pressure-related loads move through the shell. The cornea and sclera cannot be represented as mechanically identical regions, because their distinct material behavior must coexist within one continuous coat. Accounting for both factors improves interpretation of deformation and helps models connect local tissue mechanics with overall ocular support.
A useful model cannot optimize only for strength or only for optical shape. The corneal region requires a precise refractive surface, whereas the shell as a whole must provide mechanical support and distribute intraocular-pressure loads. Separating these roles helps engineers evaluate how changes in geometry or material properties could affect both vision and structural behavior.
At minimum, geometry, stiffness, anisotropy, and deformation are the central descriptors identified for bioengineering characterization. Together, they provide the structural and mechanical inputs needed to represent pressure loading and tissue response in a finite-element model. Characterizing these properties also allows investigators to compare different disease or injury conditions without reducing the shell to a single uniform material.
Its geometry and mechanical behavior matter whenever a device or procedure interacts with the ocular surface or changes its shape. Characterizing stiffness, anisotropy, and deformation gives designers information for evaluating contact-lens concepts and surgical approaches. The same data can reveal how design choices may influence optical shape, pressure-load distribution, and the mechanical support needed for eye health.
Bioengineering studies use shell mechanics to connect altered tissue behavior with changes in ocular form and function. Geometry, stiffness, anisotropy, and deformation can be incorporated into investigations of disease and injury, then used to guide biomimetic ocular implant development. The resulting analyses help relate structural changes to vision and eye health, rather than treating those outcomes independently.