Noninvasive Imaging
Noninvasive Imaging - Related Videos
09:31
Noninvasive Blood Pressure Measurement Techniques
0 Views •
2023
Source: Hamna J. Qureshi and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Here we will highlight the key similarities and differences of noninvasive blood pressure measurement techniques between humans and rodents and examine the engineering principles that govern blood pressure. The principles that govern current cuff technology to acquire systolic and diastolic pressures will also be discussed. Commercially available cuffs that connect...
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
10:17
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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Cited by 2 •
2025
This study introduces a novel approach for real-time cardiac mapping using a noninvasive, imageless electrocardiographic imaging system. This system enables the acquisition of electrophysiological cardiac maps without requiring pre-procedural computed tomography or magnetic resonance imaging scans, enabling efficient guidance for cardiac procedures such as ablation and cardiac resynchronization therapy implants.
07:09
In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
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Cited by 17 •
2014
In this study, the use of an in situ loading device coupled with micro-X-ray computed tomography for fibrous joint biomechanics will be discussed. Experimental readouts identifiable with an overall change in joint biomechanics will include: 1) reactionary force vs. displacement, i.e. tooth displacement within the alveolar socket and its reactionary response to loading, 2) three-dimensional (3D) spatial configuration and morphometrics, i.e. geometric relationship of the tooth with the alveolar...
04:36
Noninvasive Electrocardiography in the Perinatal Mouse
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Cited by 3 •
2020
Here, we present a noninvasive electrocardiography (ECG) protocol, optimized for early postnatal mice, that does not require the use of anesthetics.
FAQs
Image formation depends on contrasts in tissue properties. A modality transmits or detects a surface-accessible signal, and tissues respond differently according to their physical characteristics. Those differences become measurable patterns that can be processed into an image. The resulting contrast allows internal structures or processes to be compared without removing tissue, supporting characterization of anatomy or engineered materials.
Noninvasive imaging can use sound waves, magnetic responses, light, or radiation, so the signal source determines what information is available. These modalities do not simply photograph the body; they detect responses at the surface and translate them into representations of internal structure or function. In bioengineering, selecting among them can align the measurement with a tissue, organ, biomaterial, or device question.
Signal processing and computational reconstruction are the bridge between detected surface signals and interpretable images. Processing organizes or transforms the measured responses, while reconstruction uses those processed data to estimate internal structures, functions, or processes. Without these steps, measurements at the body surface would not directly provide the spatially organized information needed for characterization, diagnosis, or research.
Repeated measurements make it possible to follow changes in a biological system, biomaterial, or device over time while limiting the need for surgical entry or tissue removal. This longitudinal perspective can reveal whether a disease or therapy is changing, and it supports monitoring rather than relying on a single observation. The same principle strengthens evaluation during development and treatment design.
A general workflow begins by positioning the signal source or detector at the body surface, then collecting responses associated with internal tissues or materials. The measurements undergo signal processing and computational reconstruction before researchers interpret the resulting images. Depending on the study goal, the output can describe structure, function, or process, and can be recorded repeatedly for comparison across time.
Beyond visual inspection, these methods can produce quantitative data for comparing tissue or organ characteristics, assessing biomaterials, or tracking changes during therapy. Quantification turns image-derived observations into measurements that can support diagnosis, research, and treatment design. Its value depends on linking the measured signal patterns to the specific structural, functional, or process-related question under investigation.
In bioengineering, noninvasive imaging contributes to several stages of development and evaluation. Researchers can characterize tissues and organs, examine biomaterials, assess devices, and monitor disease or therapy without surgically entering the measurement site. These uses connect imaging with design decisions: observations about internal structure or function can inform device development, material evaluation, and more personalized treatment planning.