Probe Insertion Technique
Probe Insertion Technique - Related Videos
06:40
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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Cited by 99 •
2013
Insertion of flexible neural microelectrode probes is enabled by attaching probes to rigid stiffeners with polyethylene glycol (PEG). A unique assembly process ensures uniform and repeatable attachment. After insertion into tissue, the PEG dissolves and the stiffener is extracted. An in vitro test method evaluates the technique in agarose gel.
02:58
Laser Doppler Needle Probe Insertion: A Technique for Real-time Quantification of Blood Flow within the Spinal Cord in a Porcine Model
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2025
This video demonstrates the placement of a laser Doppler needle probe in the spinal cord of a porcine model. This helps in the continuous quantification of blood supply to the spinal cord, an important assessment in spinal cord injury.
09:47
A Microfluidic Technique to Probe Cell Deformability
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Cited by 20 •
2014
We demonstrate a microfluidics-based assay to measure the timescale for cells to transit through a sequence of micron-scale constrictions.
06:31
Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique
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Cited by 25 •
2013
Probe-based confocal laser endomicroscopy enables real-time microscopy of the human urinary tract during cystoscopy, providing dynamic, intravital imaging of pathological states such as bladder cancer with cellular resolution. Endomicroscopy may augment the diagnostic accuracy of standard white light endoscopy and provide intraoperative image guidance to improve surgical resection.
02:22
Positioning Laser Doppler Probe: A Technique to Implant Probe Over Middle Cerebral Artery for Blood Flow Measurement in Murine Model
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2025
This video describes the surgical procedure to immobilize the laser Doppler probe over the murine brain's middle cerebral artery, or MCA. The probe helps to measure the blood flow in the brain's microvasculature by measuring the Doppler shift caused due to the motion of red blood cells within the artery.
FAQs
Success depends on guided positioning, controlled force, accurate alignment, and placement at a defined depth. These factors work together to limit tissue deformation and mechanical damage while keeping the probe positioned for localized measurement or signal delivery. In bioengineering studies, controlling them improves measurement stability and makes device evaluations more reproducible.
The interaction between the probe and surrounding tissue affects how much the tissue deforms and whether mechanical damage occurs during placement. Understanding this interaction helps researchers balance secure positioning with minimal disturbance to the biological environment. That balance is especially important when evaluating implantable devices, because tissue response can influence stability, performance, and biocompatibility.
Alignment directs the probe toward the intended region, while defined depth determines where sensing, recording, or stimulation occurs. Poor control of either factor can reduce the consistency of localized measurements or signal delivery by placing the probe away from the target position. Careful alignment and depth control therefore support reproducible bioengineering experiments and device assessments.
A general workflow includes guided positioning, controlled advancement with appropriate force, alignment with the intended location, and placement at a defined depth. The process should also account for tissue deformation and mechanical damage while maintaining the probe in a stable position. These steps create the conditions needed for localized measurements or controlled signal delivery.
Researchers apply this technique when they need localized electrophysiological recording, biochemical sensing, drug delivery, or controlled stimulation within biological tissue or a bioengineered system. It also supports evaluation of implantable devices. The appropriate use depends on whether the study prioritizes measurement, signal delivery, therapeutic transport, or assessment of device performance and tissue compatibility.
After placement, researchers can examine measurement stability, device performance, reproducibility, and biocompatibility. These outcomes indicate whether the probe remains suitably positioned, provides consistent localized information or signal delivery, and interacts acceptably with its biological environment. Together, they help guide improvements to implantable systems and support research or clinical applications in bioengineering.