Mouse Liver
Mouse Liver - Related Videos
03:42
Isolation of Marginating Hepatic Leukocytes from a Mouse Liver
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2025
In this video, we demonstrate the isolation of marginating hepatic leukocytes from mouse liver by forced perfusion.
11:44
Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
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Cited by 3 •
2016
Here, we present a novel humanized mouse liver model generated in Alb-toxin receptor mediated cell knockout (TRECK)/SCID mice following the transplantation of immature and expandable human hepatic stem cells.
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Cited by 1 •
2025
Mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD) with metabolic dysfunction, hepatic gene expression changes, and liver histopathological alterations that resemble human MASLD, including fibrosis that progresses to advanced fibrosis stage 3. This model can be used in studies of MASLD pathophysiology and in pre-clinical studies of new therapies.
03:06
Developing a Humanized Mouse Model with Human Liver Cells and Immune Cells
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2025
This video demonstrates a method for generating a dual humanized mouse model with a human immune system and liver cells. It involves transplanting human liver cells and hematopoietic stem and progenitor cells into a transgenic immunodeficient mouse via intrasplenic injection, leading to engraftment of liver cells and development of human immune cells.
00:10
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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Cited by 7 •
2019
This protocol provides a reliable method to establish humanized mice with both human immune system and liver cells. Dual reconstituted immunodeficient mice achieved via intrasplenic injection of human hepatocytes and CD34+ hematopoietic stem cells are susceptible to human immunodeficiency virus-1 infection and recapitulate liver damage as observed in HIV-infected patients.
FAQs
Lobules provide an organized structural framework in which hepatocytes are positioned around blood vessels. This arrangement places these cells within the liver’s functional units, allowing them to act on nutrients and substances carried through the blood while directing bile secretion toward ducts. Studying this organization helps researchers connect liver structure with its metabolic and processing activities.
Hepatocytes carry out several distinct processing tasks within the lobules. They modify carbohydrates, lipids, and proteins, and they also act on drugs and other potentially harmful substances present in the blood. At the same time, they secrete bile into ducts. Examining these activities helps researchers study how the liver coordinates metabolism, detoxification, and bile production.
Mouse liver research supports controlled genetic and experimental studies because investigators can examine liver biology within a defined research model. This makes it possible to investigate how genetic or experimental conditions relate to liver development, regeneration, metabolism, infection, and disease. Findings can then help identify biological mechanisms that may be relevant to human health.
Researchers can use mouse liver models to examine several stages and conditions of liver biology, including development, regeneration, metabolism, infection, and disease. These areas represent different questions about how liver tissue forms, maintains function, responds to biological challenges, or changes during illness. Using one model system across these topics supports controlled comparisons between experimental conditions.
Mouse liver tissue can be examined to evaluate how drugs affect liver-related processing and whether experimental exposure is associated with harmful effects. Because hepatocytes modify drugs and other substances from the blood, the tissue provides a relevant setting for studying drug handling and toxicity. Such experiments can help identify biological mechanisms connected with potential health risks.
Results from mouse liver experiments can help identify biological mechanisms relevant to human health, particularly in metabolism, disease, regeneration, infection, and drug toxicity. The model does not replace investigation of human biology, but it provides a controlled experimental context for exploring these processes and generating evidence about mechanisms that may warrant further study.