Population Genetics
Population Genetics - Related Videos
01:25
What is Population Genetics?
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2026
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.While some alleles of a given gene might be observed commonly, other variants...
10:21
Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive
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Cited by 12 •
2007
In this interview, Jason Rasgon explains the concept of genetic drive and the characteristics of an effective gene drive system. The use of the endosymbiotic bacterium, Wolbachia pipientis, as a means to spread genes through mosquito populations, is hypothesized.
13:13
Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
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Cited by 5 •
2021
Here, we present a method for investigating neurite morphogenesis in postnatal mouse retinal explants by time-lapse confocal microscopy. We describe an approach for sparse labeling and acquisition of retinal cell types and their fine processes using recombinant adeno-associated virus vectors that express membrane-targeted fluorescent proteins in a Cre-dependent manner.
05:51
Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations
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Cited by 3 •
2021
This protocol provides the steps from DNA extraction to experimental set-up for digital droplet PCR (ddPCR), including analysis for the identification and quantification of non-homologous end-joining (NHEJ) events at target sites following gRNA-induced Cas9 cleavage and DNA repair. Other uses of this method include applications such as polymorphism detection and gene-editing variant verification.
14:47
Population Growth - Student Protocol
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2019
Exponential Population Growth Model ExpandNOTE: In these experiments you will use computer software to simulate different types of growth models. HYPOTHESES: The experimental hypothesis might be that if we increase either R, the reproductive rate or the initial population size, NT, that this will increase the population size after 10 generations in an exponential growth model compared to unmanipulated control populations. The null hypothesis may be that populations of different R and initial...
FAQs
Changes in allele frequencies reflect the combined effects of several evolutionary forces, rather than a single process. Mutation and recombination contribute to the variation available, while natural selection, genetic drift, and gene flow alter how that variation is distributed. Examining these forces together helps explain why gene pools differ among populations or shift through time.
Mutation and recombination affect the variation that enters inheritance, whereas selection, drift, and gene flow affect its distribution among gene pools. Keeping these contributions separate allows an analysis to ask whether observed differences reflect the generation or reshuffling of variation, evolutionary change, chance-related shifts, or movement between populations. That separation strengthens interpretation of genomic patterns.
Gene flow connects populations through migration, while isolation reduces that exchange. Comparing populations with different degrees of movement or separation can therefore reveal whether their genetic patterns are shaped by shared gene pools or restricted interaction. This comparison helps interpret differences among populations, evaluate genetic diversity, and understand how isolation contributes to population history.
A population-genetics investigation can begin by measuring allele frequencies in one or more gene pools and comparing them across time or populations. Researchers then combine mathematical models with genomic data to evaluate the effects of mutation, recombination, selection, drift, or gene flow. The resulting analysis can estimate genetic diversity, identify adaptation, or reconstruct population history.
For conservation biology, these analyses provide evidence about genetic diversity and the consequences of migration or isolation. Comparing populations can help identify whether gene pools are becoming more distinct or whether movement connects them. Such information supports conservation planning by placing population history and evolutionary change into the assessment of populations that may require management attention.
Population genetics connects evolutionary analysis with practical biological questions. In disease research, it can examine genetic variation and population change; in agriculture, it can inform studies of traits and diversity; and under environmental change, it can assess how populations respond. These uses apply allele-frequency analysis across disease-related, agricultural, ecological, and other biological systems.