De Novo Metastasis
De Novo Metastasis - Related Videos
05:51
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
0 Views •
Cited by 11 •
2011
Molecular genetic strategy for finding de novo mutations causing common disorders such as autism and schizophrenia.
08:41
Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
0 Views •
Cited by 6 •
2017
Pre-clinical models evaluating adjuvant therapy targeting breast cancer metastasis are lacking. To address this, we developed a murine model of de novo pulmonary mammary adenocarcinoma metastasis, wherein therapies administered in the adjuvant setting (post surgical resection of primary tumors) can be evaluated for efficacy in impacting previously seeded pulmonary metastases.
08:28
Experimental Metastasis Assay
0 Views •
Cited by 28 •
2010
This article describes the procedures of an experimental metastasis assay that is used to determine the metastatic potential of human cancer cell lines.
11:43
Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
0 Views •
Cited by 6 •
2016
The ability of metastatic clones to colonize distant sites depends on their proliferation capacity and/or their ability to survive in the host microenvironment without significant proliferation. Here, we present an animal model that allows quantitative visualization of both types of liver colonization by metastatic clones.
10:41
Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
0 Views •
Cited by 7 •
2017
This protocol outlines a comparative de novo transcriptome assembly and annotation workflow for novice bioinformaticians. The workflow is available for free entirely through CyVerse and connected by the Data Store. Command line and graphical user interfaces are used, but all code needed is available to copy and paste.
FAQs
Successful distant spread requires more than movement away from the primary tumor. Cancer cells must enter blood or lymphatic vessels, remain viable during circulation, and then establish growth in a distant tissue. This sequence makes each stage a potential barrier and helps investigators study why only certain disseminated cells successfully form secondary lesions.
The local microenvironment can determine whether disseminated cancer cells survive and grow. Tissues differ in how well they support colonization, so the same tumor may produce lesions preferentially in particular organs. Examining these tissue-level interactions helps cancer researchers connect organ-specific patterns with the conditions that permit secondary tumor establishment.
A primary tumor may contain diverse cancer cell populations, and those differences can affect dissemination, survival in circulation, and growth at distant sites. Studying de novo metastasis therefore requires attention to variation within the cancer rather than treating every cell as equivalent. This perspective can clarify why metastatic disease may show distinct biological features at diagnosis.
Recognizing distant disease at the initial evaluation is essential for accurate staging, because staging must account for lesions outside the primary site. The finding also supports molecular profiling and treatment selection, while emphasizing that disease may already be systemic when care begins. This information guides how researchers and clinicians frame the cancer’s extent.
Molecular profiling is important because metastatic presentation can be evaluated as a biologically heterogeneous disease rather than as an isolated primary tumor. In the context of de novo metastasis, profiling contributes to treatment selection and helps investigators examine features associated with early dissemination. Its value is therefore both practical and mechanistic.
Research on this presentation focuses attention on processes that occur before or at the first recognition of systemic disease, including early dissemination, organ-specific colonization, and interactions with surrounding tissue. These insights can support therapies designed to limit systemic disease from the outset, rather than addressing distant spread only after localized treatment.