On-surface Synthesis
On-surface Synthesis - Related Videos
09:36
Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism
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Cited by 2 •
2018
We report a solution-based method to synthesize substrate-bound Au nanowires. By tuning the molecular ligands used during the synthesis, the Au nanowires can be grown from various substrates with different surface properties. Au nanowire-based nanostructures can also be synthesized by adjusting the reaction parameters.
08:33
Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
08:42
Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
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Cited by 5 •
2017
We present a novel microfluidic-based method for synthesis of covalent organic frameworks (COFs). We demonstrate how this approach can be used to produce continuous COF fibers, and also 2D or 3D COF structures on surfaces.
09:42
Solid Phase Synthesis
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2023
Source: Vy M. Dong and Diane Le, Department of Chemistry, University of California, Irvine, CA Merrifield's solid-phase synthesis is a Nobel Prize winning invention where a reactant molecule is bound on a solid support and undergoes successive chemical reactions to form a desired compound. When the molecules are bound to a solid support, excess reagents and byproducts can be removed by washing away the impurities, while the target compound remains bound to the resin. Specifically, we will...
02:17
Synthesis and Decomposition Reactions
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2020
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. Synthesis Reactions Synthesis reactions are also called combination reactions. It is a reaction in which two or more substances combine to form a complex substance. Synthesis reactions are generally represented as: A + B → AB or A + B → C. The formation of nitrogen dioxide is a synthesis...
FAQs
Surface confinement increases the likelihood that deposited reactants encounter one another because the solid interface restricts their organization. This spatial control can promote ordered bond formation and reduce the freedom available in a less constrained environment. As a result, molecular placement becomes part of the reaction design, which is important when preparing atomically defined nanostructures.
Thermal activation supplies the trigger needed to initiate bond-forming reactions after reactants have been deposited. Heating can enable the system to move from surface-bound reactants through reactive intermediates toward covalent products, while the substrate helps stabilize those intermediates. Controlling this activation step therefore influences whether the intended molecular or extended structure forms.
Surface-stabilized intermediates can remain sufficiently organized for subsequent reactions to occur in a guided manner. The substrate not only supports the reacting species but also influences how they are positioned as bonds form. This connection between intermediate stabilization and spatial arrangement helps explain how On-surface Synthesis can produce ordered covalent architectures rather than only isolated molecular products.
A typical workflow begins by depositing selected reactants onto a suitable solid substrate. The deposited species are then exposed to thermal activation or another stimulus that initiates covalent bond formation. Finally, the resulting structures and, when possible, reaction pathways are examined with surface analysis methods such as scanning tunneling microscopy to connect molecular design with observed products.
Scanning tunneling microscopy can reveal the structures produced on the surface and provide information about how molecular arrangements change during the reaction. When observations include reaction pathways as well as final products, researchers can relate the covalent architecture to the sequence of surface processes that generated it. This makes the method useful for linking synthesis with nanoscale characterization.
The approach can support preparation of atomically defined nanostructures, graphene-like materials, and covalent organic networks. Its value lies in combining molecular design with surface-directed organization, allowing researchers to investigate structures whose composition and arrangement are controlled at the nanoscale. These products connect synthetic chemistry with the study of extended two-dimensional materials and molecular-scale organization.