Schlenk Vessel Reaction
Schlenk Vessel Reaction - Related Videos
09:41
Schlenk Lines Transfer of Solvents
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2023
Source: Hsin-Chun Chiu and Tyler J. Morin, laboratory of Dr. Ian Tonks—University of Minnesota Twin Cities Schlenk lines and high vacuum lines are both used to exclude moisture and oxygen from reactions by running reactions under a slight overpressure of inert gas (usually N2 or Ar) or under vacuum. Vacuum transfer has been developed as a method separate solvents (other volatile reagents) from drying agents (or other nonvolatile agents) and dispense them to reaction or storage vessels while...
07:05
Handling Air- and Water-Sensitive Chemicals Using a Schlenk Line
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2023
Robert M Rioux, Ajay Sathe, Zhifeng Chen, Pennsylvania State University, University Park, PA The use of reagents sensitive to oxidation or moisture necessitates the use of air-free techniques. A Schlenk line is a routinely used glass apparatus to perform air and moisture free manipulations in a chemical laboratory1. The Schlenk line is widely utilized by many chemists since it allows them conduct air or water sensitive reactions even without the expense and restriction of a glove box. The...
06:50
Synthesis Of A Ti(III) Metallocene Using Schlenk Line Technique
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2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University Inorganic chemists often work with highly air- and water-sensitive compounds. The two most common and practical methods for air-free synthesis utilize either Schlenk lines or gloveboxes. This experiment will demonstrate how to perform simple manipulations on a Schlenk line with a focus on solvent preparation and transfer. Through the synthesis of a reactive Ti(III) metallocene complex, we will demonstrate a new, simple...
09:09
Conducting Reactions Below Room Temperature
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2023
Source: Laboratory of Dr. Dana Lashley - College of William and Mary Demonstration by: Matt Smith When new bonds are formed in the course of a chemical reaction, it requires that the involved species (atoms or molecules) come in very close proximity and collide into one another. The collisions between these species are more frequent and effective the higher the speed at which these molecules are moving. A widely used rule of thumb, which has its roots in the Arrhenius equation1, states that...
05:56
Operation of High-pressure Reactor Vessels
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2023
Robert M Rioux, Pennsylvania State University, University Park, PA The use of gases in a synthetic chemistry laboratory is essential for carrying out a variety of highly facile and atom economical transformations. Reactions such as hydrogenation, oxidation, and amination require the use of gases like hydrogen, oxygen, and ammonia. Due to the poor solubility of these gases in typical reactant solutions, high pressures are necessary to achieve a meaningful reaction rate. Not only are these gases...
FAQs
Air removal depends on cycling rather than a single evacuation. The vessel connects to a Schlenk line, is evacuated, and is then backfilled with nitrogen or argon. Repeating this sequence progressively displaces residual air before reagents are combined. That controlled preparation reduces contact with oxygen and moisture, which is especially important for sensitive organometallic reagents and catalysts.
Vacuum and inert gas serve different roles. Evacuation removes air from the vessel, while nitrogen or argon provides the selected atmosphere for handling the reagents and reaction mixture. Using these conditions in sequence allows researchers to prepare the vessel thoroughly and then maintain an environment that limits exposure to oxygen and moisture during the transformation.
The stopcock acts as the vessel’s isolation point after the desired atmosphere has been established. It helps maintain either the selected inert-gas environment or vacuum while the mixture is stirred, heated, or cooled. Keeping that condition stable limits re-exposure to laboratory air and supports consistent reaction handling throughout the transformation.
Controlled atmosphere reduces variability caused by uncontrolled contact with oxygen and moisture. Repeated air removal, followed by isolation under nitrogen, argon, or vacuum, gives the reagents a more consistent environment from one experiment to another. This is particularly relevant when preparing air- or moisture-sensitive catalysts, intermediates, and materials whose behavior depends on careful handling.
The setup includes a specialized Schlenk vessel connected to a Schlenk line, a stopcock for isolation, and a source of nitrogen or argon for backfilling. After air removal, the vessel can support stirring, heating, or cooling while maintaining the chosen atmosphere. These components work together to keep reaction conditions controlled during the experiment.
Researchers choose this approach when reagents or products are sensitive to air or moisture, especially in organometallic chemistry. It supports the preparation of catalysts, intermediates, and materials that require protection from oxygen and water. The method also enables transformations that cannot be performed safely or reliably under ordinary open laboratory conditions.