Sodium Borohydride Reaction

The sodium borohydride reaction is a chemical reduction that uses sodium borohydride (NaBH₄) to convert aldehydes and ketones into alcohols, making it an important transformation in organic chemistry. In the reaction, a hydride ion is transferred from borohydride to the electrophilic carbonyl carbon, forming an alkoxide intermediate that is subsequently protonated to produce the alcohol. Because sodium borohydride is a relatively mild and selective reducing agent, it can reduce carbonyl compounds under conditions that preserve many other functional groups. This reaction supports alcohol synthesis, structural analysis, laboratory instruction, and multistep preparation of pharmaceutical and other organic compounds.

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JoVE Core - Chemistry

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