Vascular Stage
Vascular Stage - Related Videos
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
01:22
Stages of Sleep
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2024
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions. Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
01:22
Stages of General Anesthesia
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2024
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
03:33
Visualization of Neural and Vascular Networks in a Chicken Embryo
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2025
Source: Delalande, J., et.al. Dual Labeling of Neural Crest Cells and Blood Vessels Within Chicken Embryos Using ChickGFP Neural Tube Grafting and Carbocyanine Dye DiI Injection. J. Vis. Exp. (2015)This video demonstrates the transplantation of a GFP-labeled donor neural tube from a stage-matched transgenic chicken embryo into a recipient embryo at the level of somites one to seven, followed by vascular labeling using a lipophilic fluorescent dye. The combined approach allows for direct...
FAQs
Changes in vascular tone modify vessel diameter and therefore influence blood flow through affected tissues. At the same time, endothelial cells regulate aspects of vessel behavior, including permeability and interactions associated with inflammation. Together, these changes can alter how effectively tissue receives blood and how the local environment supports injury responses or repair.
Vessel permeability determines how readily substances move between the circulation and surrounding tissue. Increased or altered permeability can accompany endothelial activity and influence inflammatory responses, tissue injury, and repair. Evaluating this feature alongside blood flow and vascular tone helps distinguish changes in the vascular environment from changes limited to tissue structure or perfusion alone.
Angiogenesis refers to the formation of new blood vessels, whereas vascular remodeling describes structural changes in existing vessels. These processes may follow earlier functional changes in tone, flow, endothelial activity, or permeability. Their presence can indicate a later or more sustained vascular response, making them relevant when assessing recovery, persistent injury, or adaptation within affected tissue.
Assessment can focus on functional and structural indicators, including vascular tone, endothelial cell activity, blood flow, vessel permeability, angiogenesis, and vascular remodeling. Interpreting these features together provides a broader picture than relying on a single measurement. In clinical research, this approach supports evaluation of disease progression, tissue injury, and recovery.
Researchers can apply vascular-stage assessment when studying circulatory disorders, inflammatory conditions, or impaired healing. The findings help characterize how vascular changes relate to disease progression and tissue recovery. They can also support monitoring over time, allowing investigators to examine whether perfusion, endothelial behavior, permeability, or vessel structure changes as the clinical condition evolves.
Vascular-stage findings can identify whether a condition is associated with altered endothelial function, inadequate perfusion, or changes in vessel formation and structure. That information helps focus clinical strategies on the relevant vascular feature, such as improving endothelial function, supporting tissue perfusion, or targeting new-blood-vessel formation. The intended relevance is diagnosis, monitoring, and recovery assessment.