Perigonadal White Adipose
Perigonadal White Adipose - Related Videos
03:28
White and Brown Adipose Depot Collection from Mouse Pup: A Surgical Procedure to Harvest the White Adipose Tissue and Brown Adipose Tissue from Mouse Pup
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2025
In this video, we demonstrate the surgical procedure to isolate the subcutaneous white adipose tissue and interscapular brown adipose tissue from a newborn mouse.
06:16
White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
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2025
Here we present a white and brown adipose tissue transplantation protocol that offers a promising strategy to reverse subfertility, obesity, and hyperglycemia, while improving kidney function in diabetic and obese BTBR mice.
06:19
Visualization of 3D White Adipose Tissue Structure Using Whole-mount Staining
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Cited by 19 •
2018
The focus of the present study is to demonstrate the whole-mount immunostaining and visualization technique as an ideal method for 3D imaging of adipose tissue architecture and cellular component.
06:39
Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
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Cited by 3 •
2021
This fat-covered islet transplantation method is suitable for the detection of engrafted islets in the intraperitoneal cavity. Notably, it does not require the use of biobinding agents or suturing.
08:14
A Microphysiologic Platform for Human Fat: Sandwiched White Adipose Tissue
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Cited by 7 •
2018
White adipose tissue (WAT) has critical deficiencies in its current primary culture models, hindering pharmacological development and metabolic studies. Here, we present a protocol to produce an adipose microphysiological system by sandwiching WAT between sheets of stromal cells. This construct provides a stable and adaptable platform for primary WAT culture.
FAQs
Adipocytes provide the tissue’s principal energy-storage function by converting excess energy into triglycerides, while resident immune cells participate in local inflammatory regulation. Adipocyte-derived signaling molecules can influence these immune processes and extend their effects beyond the depot. This interaction makes the tissue useful for examining how metabolism and immunity operate together rather than as separate systems.
Signals produced by adipocytes can shape inflammation within the surrounding tissue and contribute to systemic immune responses. Their importance lies in connecting the metabolic condition of fat cells with the behavior of immune cells. Studying these signals helps researchers investigate how changes in energy storage may influence inflammatory regulation and host responses during disease.
Nutritional state can alter the relationship between energy storage, adipocyte signaling, and immune regulation in perigonadal white adipose. When this relationship changes, local inflammation and broader immune responses may also be affected. This framework is especially relevant to research on obesity, where altered adipose biology may help explain differences in inflammation and infection susceptibility.
Researchers can examine adipose inflammation, leukocyte recruitment, metabolic changes, and host responses during disease. Together, these features show how immune cells enter or function within the tissue, how the depot’s metabolic state changes, and how local events may relate to systemic immunity. The combination supports a multidimensional analysis rather than relying on inflammation alone.
Its accessibility makes perigonadal white adipose a practical model for investigating interactions among adipocytes, resident immune cells, and disease-related immune responses. Studies can use the depot to connect local tissue inflammation with systemic effects, while also considering nutritional state. This is valuable for clarifying mechanisms that link obesity, inflammation, and susceptibility to infection.
This depot can help address how excess energy storage becomes associated with inflammatory regulation and altered host responses during disease. Researchers can ask whether adipocyte-derived signals, resident immune cells, or leukocyte recruitment contribute to those links. Findings may clarify how nutritional conditions shape immunity and identify mechanisms connecting adipose inflammation with infection susceptibility.