Biomaterial Safety
Biomaterial Safety - Related Videos
07:44
Overview of Biomaterials
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2023
Biomaterials are materials engineered to interact favorably with biological organisms or molecules. These materials can be derived from or produced by an organism, or can even be a synthesized polymer. Engineers use these novel materials in a wide range of applications, such as tissue engineering, biosensing and drug delivery. This video introduces common biologically derived materials, and provides examples of common techniques used to process them. Key challenges in the field are discussed,...
07:58
Electrospinning of Silk Biomaterials
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2023
Silk fibers have been processed and used to create fabrics and threads for centuries. However, the solubilizing of silk fibers, thereby turning it into a versatile pre-polymer solution is a much newer technology. Solubilized silk can be processed in many different ways to create a biocompatible material with controllable mechanical properties. This video introduces the processing of silk from silk worm cocoons, and shows how the silk solution can be used to create a fiber mat via...
02:39
Fluorescence Imaging of Biomaterial-Associated Bacterial Infection in Zebrafish Embryos
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2025
Source: Zhang, X., et al. A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. J. Vis. Exp. (2019)This video demonstrates fluorescence imaging of zebrafish embryos injected with Staphylococcus aureus, enabling quantification of infection progression and bacterial distribution to assess the impact of biomaterial microspheres on host-pathogen interactions in vivo.
04:53
Electrical Safety
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2023
Robert M. Rioux & Suprita Jharimune, Pennsylvania State University, University Park, PA Among the many hazards present in the laboratory, electrical hazards are one of the most common we must be cognizant of since most of the laboratory equipment we use requires electricity for operation. Improper handling or operation of electrical devices might lead to electric shock with the potential risk of injury or even death. Electric sparks can lead to fire or explosion (since many flammable...
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Cited by 20 •
2012
Surgical stages of bladder augmentation are described using 3-D scaffolds in murine and rat models. To test the efficacy of biomaterial configurations for use in bladder augmentation, techniques for both awake and anesthetized cystometry are presented.
FAQs
Chemical composition determines which substances may interact with cells, tissues, and biological fluids, while surface properties influence how surrounding biological structures respond at the material interface. These factors can affect toxicity, inflammation, immune reactions, and infection risk. Evaluating them together helps researchers identify whether a material is suitable for its intended medical contact or implantation.
A material may change after exposure to biological fluids, producing degradation products that interact with nearby cells and tissues. Safety assessments therefore consider not only the original material but also what it becomes during use. This information helps determine whether breakdown could contribute to toxicity, inflammation, immune reactions, or other unacceptable tissue responses over the expected service period.
Mechanical behavior matters because a material must perform its intended function while remaining compatible with surrounding tissues. Changes or failures in mechanical performance can alter how the device interacts with the body and may influence local tissue responses. Considering mechanical behavior alongside composition, surface characteristics, and degradation provides a more complete basis for material selection and device design.
These evaluations address different safety concerns. Biocompatibility examines compatibility with biological systems, sterility addresses the presence of microorganisms, stability considers whether the material maintains relevant properties, and tissue-response testing examines effects in surrounding tissues. Together, they provide complementary evidence rather than a single safety result, helping identify risks associated with medical devices and prolonged tissue contact.
Testing should reflect the material’s intended use and relevant contact conditions. Evaluators consider whether the product will contact cells, tissues, or biological fluids and whether contact is temporary, prolonged, or associated with implantation. Assessments may then examine composition, surface properties, degradation, mechanical behavior, sterility, stability, and tissue responses under those relevant use conditions.
A typical evaluation begins by identifying the material’s intended medical function and biological contact. Investigators then assess properties such as chemical composition, surface characteristics, degradation behavior, and mechanical performance, followed by relevant tests for biocompatibility, sterility, stability, and tissue responses. The resulting evidence supports decisions about material selection, device design, and risk reduction.
These assessments are used when selecting materials for medical devices, implants, and other tissue-contacting products, especially when contact with the body may be prolonged. They help researchers compare design options, identify potential toxicity or inflammatory responses, and reduce risks before clinical use. The findings also contribute to development and approval of safer medical technologies.
Testing can reveal whether a material performs its intended function without causing unacceptable harm under relevant use conditions. Results may identify risks involving toxicity, inflammation, immune reactions, infection, instability, degradation, or tissue response. This evidence guides material selection and device design while supporting decisions related to development, approval, and eventual clinical use.