Cardiac Hypertrophy Assessment
Cardiac Hypertrophy Assessment - Related Videos
10:18
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Cited by 17 •
2014
We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.
06:51
Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and in vitro Cardiac Hypertrophy
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Cited by 74 •
2014
We describe a reliable method for isolation of adult mouse cardiomyocytes. This protocol yields a consistent result for the culture of functional adult cardiomyocytes from a variety of genetically modified mice.
09:05
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
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Cited by 25 •
2016
The goal of this protocol is to noninvasively assess cardiac structural and functional changes in a mouse model of heart disease created by transverse aortic constriction, using B- and M-mode echocardiography and color/pulse wave Doppler imaging.
11:10
Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers
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Cited by 32 •
2011
Saponin-permeabilized fiber preparation in conjunction with respirometric oxidative phosphorylation analysis provides integrative assessment of mitochondrial function. Mitochondrial respiration in physiological and pathological states can reflect various regulatory influences including mitochondrial interactions, morphology and biochemistry.
08:34
Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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Cited by 34 •
2017
The aim of this protocol is to describe step-by-step the technique of minimally invasive transverse aortic constriction (TAC) in mice. By elimination of intubation and ventilation which are mandatory for the commonly used standard procedure, minimally invasive TAC simplifies the operative procedure and reduces the strain put on the animal.
FAQs
Interpretation depends on whether increased muscle mass or wall thickness occurs as a normal adaptation or in association with disease. Assessment therefore combines structural measurements with ventricular function and the clinical context of pressure- or volume-related changes. This distinction matters because similar anatomical findings may represent different remodeling processes and lead to different approaches to risk assessment and management.
Pressure- and volume-related changes can produce different patterns of cardiac remodeling, so identifying the likely hemodynamic stress provides important context for measured wall thickness, ventricular dimensions, and mass. These measurements should not be considered in isolation. Linking structural findings to the type of sustained stress helps clinicians interpret disease-related remodeling and evaluate how cardiac performance is being affected.
Echocardiography and cardiac magnetic resonance provide structural and functional information, including ventricular dimensions, wall thickness, mass, and performance. Electrocardiography contributes complementary evidence of electrical remodeling rather than directly measuring anatomy. Using these perspectives together can strengthen evaluation by relating changes in cardiac structure to associated electrical changes and functional consequences.
A basic evaluation can include ventricular dimensions, wall thickness, ventricular mass, and measures of cardiac function. Echocardiography or cardiac magnetic resonance supplies the principal structural assessment, while electrocardiography can add evidence of electrical remodeling. Reviewing these measurements together supports a more complete characterization of the heart rather than relying on a single indicator of increased muscle mass.
The assessment is particularly useful when clinicians need to characterize pressure- or volume-related remodeling, distinguish hypertrophic cardiomyopathy from other causes, or determine whether structural changes are progressing. Repeated evaluations can also show whether the heart responds to treatment. These uses make the assessment relevant to diagnosis, longitudinal follow-up, and clinical risk stratification.
Serial measurements allow clinicians to compare ventricular dimensions, wall thickness, mass, and function over time. A follow-up study can indicate whether remodeling is stable, progressing, or changing after treatment, while electrocardiography may provide corresponding evidence of altered electrical remodeling. Together, these observations support risk stratification and help connect structural change with clinical management decisions.