Cardiopulmonary Bypass
Cardiopulmonary Bypass - Related Videos
08:08
Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
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Cited by 9 •
2017
This paper describes how to perform cardiopulmonary bypass in mice. This novel model will facilitate the investigation of the molecular mechanisms involved in organ damage.
09:54
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
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Cited by 2 •
2018
Here, we present a protocol to describe a simple recovery cardiopulmonary bypass model without transfusion or inotropic agents in a rat. This model allows the study of the long-term multiple organ sequelae of cardiopulmonary bypass.
07:37
Roux-en-Y Gastric Bypass Operation in Rats
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Cited by 45 •
2012
Numerous studies using gastric bypass rat models have been recently conducted to uncover the underlying physiological mechanisms of Roux-en-Y gastric bypass operations. This article aims to demonstrate and discuss the technical and experimental details of our published gastric bypass rat model to understand advantages and limitations of this experimental tool.
05:17
Cardiopulmonary Complex Decellularization: A Technique for Decellularizing Heart and Lungs from Murine Model
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2025
This video demonstrates a method of producing decellularized extracellular matrix or ECM scaffolds by applying antegrade perfusion of detergents through the vasculature. The structural ECM scaffolds can then be used to analyze ECM remodeling associated with cardiopulmonary disease.
01:21
Cardiopulmonary Resuscitation I: Adult
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2025
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
FAQs
The oxygenator and pump perform separate but coordinated tasks in cardiopulmonary bypass. The pump drives diverted venous blood through the circuit, while the oxygenator provides gas exchange before the blood returns to arterial circulation. Their coordination maintains blood flow and oxygen delivery while cardiac and respiratory function are temporarily interrupted during surgery.
Anticoagulation protects the extracorporeal circuit from clot formation. Blood is diverted through tubing and components of the heart-lung machine, so preventing clotting is an essential operating condition. This allows blood to pass through the circuit during the surgical interval and supports the planned return of treated blood to the arterial circulation.
The heat exchanger regulates blood temperature as blood moves through the bypass circuit. Temperature control is coordinated with the pump and oxygenator before blood returns to arterial circulation. This component gives the surgical team a controlled physiologic condition while the heart and lungs are temporarily supported by the machine.
The basic sequence diverts venous blood to the heart-lung machine, moves it with a pump through an oxygenator, regulates its temperature with a heat exchanger, and returns it to arterial circulation. Anticoagulation is included to limit clot formation in the circuit. Together, these steps sustain circulation during the operative period.
Cardiopulmonary bypass supports major procedures that benefit from a still, bloodless surgical field. The overview identifies valve repair, coronary artery bypass, and congenital heart surgery as key applications. In these settings, temporarily taking over circulation and gas exchange allows surgeons to perform work on cardiac structures while systemic blood flow and oxygen delivery continue.
Beyond its operative role, cardiopulmonary bypass informs research on inflammation, organ protection, and postoperative recovery. The technique creates a clinical context for examining how temporary machine-supported circulation relates to responses after cardiac surgery. These areas help connect bypass management with efforts to understand and improve recovery following major procedures.