Mouse Lung Model
Mouse Lung Model - Related Videos
09:22
Mouse Pneumonectomy Model of Compensatory Lung Growth
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Cited by 14 •
2014
Mouse pneumonectomy is a commonly employed model of compensatory lung growth. This procedure can be used in conjunction with lineage tracing or transgenic mouse models to elucidate underlying mechanisms.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
02:36
Establishing a Mouse Model of Pleural Disseminated Lung Cancer
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2025
This video demonstrates a method to generate a mouse model of pleural dissemination by injecting lung cancer cell suspension into the thoracic cavity of an immunodeficient mouse.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
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Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
07:46
A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer
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2025
A major challenge of developing new therapies for lung cancer includes modeling the tumor microenvironment as regional disease progresses to metastatic disease. Here, we describe a simple method of establishing an orthotopic syngeneic model of lung cancer that allows for in vivo tracking of disease over time.
FAQs
Genetic modification allows researchers to examine how specific inherited or experimentally altered biological features affect respiratory disease. By connecting these changes with airway and alveolar outcomes, investigators can study molecular mechanisms rather than relying only on visible symptoms. This approach is useful for clarifying how altered biology contributes to conditions such as asthma, pulmonary fibrosis, or lung cancer.
Controlled exposure to infectious or inflammatory agents creates a defined biological challenge that can be examined under experimental conditions. Researchers can then relate the exposure to changes in lung structure, function, and tissue characteristics. This supports investigation of disease processes in infection and inflammation while providing a consistent context for comparing responses or evaluating candidate treatments.
Mouse and human lungs are not identical, so biological responses observed in mice may not translate directly to patients. Differences in lung structure, function, or disease response can affect how results should be understood. Consequently, mouse findings are valuable for clarifying mechanisms and prioritizing therapies, but they require careful interpretation before clinical studies or medical conclusions.
Pulmonary function testing evaluates respiratory performance, whereas tissue analysis reveals structural and cellular changes within the lung. Using both approaches helps researchers connect functional impairment with airway or alveolar alterations. This combined perspective can show whether a disease process or treatment affects how the lungs work, how their tissues change, or both.
A study may begin by establishing the relevant biological condition through genetic modification or controlled exposure to an infectious or inflammatory agent. Researchers then assess respiratory function and examine lung tissue, linking molecular findings with airway and alveolar outcomes. This workflow provides complementary evidence for understanding disease mechanisms and judging responses to a candidate therapy.
Mouse lung studies are used to investigate candidate treatments in the context of diseases such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, infection, and lung cancer. Researchers can assess treatment responses alongside molecular, functional, and tissue-level changes. The resulting evidence may help clarify mechanisms and inform decisions about therapies that warrant further evaluation before clinical studies.