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January 27, 2015
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Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
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Cite this Article
Limjunyawong, N., Fallica, J., Horton, M. R., Mitzner, W. Measurement of the Pressure-volume Curve in Mouse Lungs. J. Vis. Exp. (95), e52376, doi:10.3791/52376 (2015).
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