Mouse Trauma Model
Mouse Trauma Model - Related Videos
07:01
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Cited by 68 •
2015
An Achilles tenotomy and burn injury model of heterotopic ossification allows for the reliable study of trauma induced ectopic bone formation without the application of exogenous factors.
10:08
Pseudofracture: An Acute Peripheral Tissue Trauma Model
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Cited by 38 •
2011
Pseudofracture, a reproducible murine model of sterile musculoskeletal trauma, allows for evaluation of late term post-traumatic immune responses. This article describes the procedural execution of the model step by step, including the potential for experimental model combinations to permit study of multiple trauma.
11:14
Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
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Cited by 11 •
2014
Acute brain trauma is a severe injury that has no adequate treatment to date. Multiphoton microscopy allows studying longitudinally the process of acute brain trauma development and probing therapeutical strategies in rodents. Two models of acute brain trauma studied with in vivo two-photon imaging of brain are demonstrated in this protocol.
07:18
Focused Assessment with Sonography for Trauma (FAST) Exam: Image Acquisition
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Cited by 7 •
2023
The Focused Assessment with Sonography for Trauma (FAST) exam is a diagnostic point-of-care ultrasound examination used to screen for the presence of free fluid in the pericardium and peritoneum. Indications, techniques, and pitfalls of the procedure are discussed in this article.
09:55
Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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Cited by 6 •
2018
We present a protocol of personalized script-driven trauma-related imagery and clinical assessments within a comparison design for investigating peritraumatic dissociation (PD), psychophysiological reactions, i.e. heart rate (HR) and skin conductance (SC), and psychological features of often severely traumatized individuals with borderline personality disorder (BPD).
FAQs
The injury can trigger coordinated inflammatory, vascular, metabolic, and tissue-repair responses, allowing investigators to examine trauma as a multisystem process rather than as an isolated lesion. Measuring these response domains helps connect local tissue damage with changes in organ function and whole-body physiology, which is relevant when evaluating mechanisms of disease and recovery.
A controlled and defined insult makes injury severity more consistent across experimental groups. That consistency allows researchers to distinguish effects associated with the trauma from differences caused by the intervention or experimental conditions. It also supports standardized comparisons of complications, recovery, and therapeutic responses, strengthening interpretation when several treatment strategies are assessed.
Behavioral, physiological, and molecular measurements provide complementary views of outcome. Behavioral data can indicate functional consequences, physiological measurements can reflect organ or whole-body changes, and molecular measurements can characterize underlying responses. Combining these readouts helps researchers relate observable impairment to biological mechanisms instead of relying on a single indicator.
Mouse findings cannot be transferred directly to patients because mouse and human biology differ. A response that appears promising in the model may not reproduce the same way in people, so investigators must consider biological differences when interpreting injury mechanisms, treatment responses, and recovery, and when planning clinical translation.
A typical study begins by creating a defined traumatic insult, followed by monitoring responses with behavioral, physiological, and molecular measurements. Investigators can then compare injury-related outcomes across conditions, including therapeutic strategies, while examining effects on organs and whole-body function. This structured workflow links the experimental injury to measurable medical outcomes.
These models are useful when researchers need to examine disease mechanisms, complications, rehabilitation, or potential treatments after injury. In medicine, they can support preclinical evaluation of drug development and therapeutic responses, while also helping characterize injury severity and recovery. Their value is greatest when the measured outcomes match the clinical question being investigated.