Surgical Ligation
Surgical Ligation - Related Videos
07:44
Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
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Cited by 19 •
2015
This protocol describes an injury model involving the surgical ligation of the pancreatic duct in the adult mouse pancreas, resulting in severe injury that establishes an environment that allows beta cell neogenesis and proliferation. This model can be used as a tool to study mechanisms involved in beta cell formation.
11:58
Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
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Cited by 2 •
2015
Minimally invasive thumb-sized pterional craniotomy for aneurysm clipping has afforded our patients with a shorter hospital stay at a lower cost compared to the national average.
07:34
DNA Ligation Reactions
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2023
In molecular biology, ligation refers to the joining of two DNA fragments through the formation of a phosphodiester bond. An enzyme known as a ligase catalyzes the ligation reaction. In the cell, ligases repair single and double strand breaks that occur during DNA replication. In the laboratory, DNA ligase is used during molecular cloning to join DNA fragments of inserts with vectors – carrier DNA molecules that will replicate target fragments in host organisms. This video provides an...
05:48
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
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Cited by 11 •
2022
Presented here is a surgical procedure for permanent ligation of the left coronary artery in mice. This model can be used to investigate the pathophysiology and associated inflammatory response after myocardial infarction.
06:47
Generating Murine Model of Myocardial Infarction: A Surgical Procedure for Permanent Ligation of Left Anterior Descending Coronary Artery in Mouse Model
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2025
In this video, we describe a surgical procedure to generate a mouse model of myocardial infarction by permanently ligating the left anterior descending coronary artery.
FAQs
The key mechanical effect is compression of the structure’s lumen, the internal passage through which blood or fluid moves. A suture, clip, or band tightens around the target and narrows or closes that passage. In a blood vessel, this supports hemostasis; in another tubular structure, it produces a controlled blockage.
Each option provides a physical means of constricting the target structure, but the source material identifies them as distinct closure tools rather than interchangeable terms. Their shared purpose is to compress the lumen sufficiently to interrupt flow. This flexibility allows ligation to be applied to blood vessels, ducts, and other tubular structures during tissue management.
The intended outcome determines how the occlusion functions. For hemostasis, ligation interrupts blood movement to control bleeding during an operation. For intentional blockage, it prevents flow through a selected structure, such as the fallopian tubes during permanent contraception. Both uses rely on constriction, but they address different clinical goals.
The surgeon first identifies the vessel, duct, or other tubular structure that requires flow interruption. A suture, clip, or band is then positioned around the target and tightened or secured to compress its lumen. This produces hemostasis, controlled blockage, or secure management of a tissue pedicle, depending on the operative purpose.
It is used when a surgeon needs to control bleeding, secure a vessel, or manage a tissue pedicle safely. By limiting blood movement, the technique can improve operative control and help prevent complications associated with uncontrolled bleeding. Its role is therefore practical across procedures involving vessels or attached tissue structures.
A major non-hemostatic application is intentional occlusion of the fallopian tubes for permanent contraception. In this setting, the objective is not simply to manage bleeding during tissue handling, but to block a tubular pathway deliberately. This illustrates how the same flow-interrupting principle supports both operative management and a planned medical treatment.