Medial Perforant Path
Medial Perforant Path - Related Videos
07:26
Foraging Path-length Protocol for Drosophila melanogaster Larvae
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Cited by 18 •
2016
We provide a detailed protocol for a Drosophila melanogaster foraging path-length assay. We discuss the preparation and handling of test animals, how to perform the assay and analyze the data.
01:22
Mean free path and Mean free time
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2025
Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path." The mean free path varies inversely with the density of the molecules because when there are more molecules inside a volume, they have a greater chance of colliding with each other, thus reducing the mean free path. Additionally, the mean free path is inversely related to...
06:08
A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy
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2026
Medial canthopexy allows correction of the position and fixation of the medial canthal tendon. Due to the technical difficulties of this procedure, there is a need for a detailed protocol for educational purposes. Here, we describe a standardized reproducible technique for bilateral medial transnasal canthopexy by an orbitonasal approach.
04:43
Induction of a Subarachnoid Hemorrhage in a Mouse Model through Endovascular Perforation
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2025
The video demonstrates the induction of subarachnoid hemorrhage via endovascular perforation in a mouse model. An incision is made in the neck region of the anesthetized mouse to access the common carotid artery and its bifurcation. A filament is inserted through the arteries to perforate an intracranial artery branch, inducing subarachnoid hemorrhage.
01:21
Path Between Thermodynamics States
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2023
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1: In the first process for path A to C, the gas is kept at constant temperature T. It undergoes an expansion from volume V1 to V2. The work done by an ideal gas is expressed as Substituting for pressure as nRT/V from the ideal gas equation and integrating the terms, the work done by an ideal gas at constant temperature is obtained as In the second process, for path A to B, the...
FAQs
The middle molecular layer is the main dentate gyrus target described for these axons. Positioning excitatory input near granule cells allows entorhinal signals to influence dentate processing. Because the pathway carries spatial and contextual information, activity in this layer is relevant to pattern separation and synaptic plasticity associated with learning.
Its glutamatergic axons convey spatial and contextual information from medial entorhinal cortex neurons to hippocampal targets. This input gives granule cells and the CA3 region access to information used in memory-related processing. The pathway therefore links cortical representations of context and space with circuit operations involved in learning and navigation.
Crossing the hippocampal fissure enables axons arising from layer II of the medial entorhinal cortex to reach their targets in the dentate gyrus and CA3 region. This anatomical route connects cortical input with hippocampal processing zones, making the pathway's projection pattern important when relating circuit structure to memory, navigation, or dysfunction.
Researchers can treat this pathway as a circuit model for examining how entorhinal input influences hippocampal processing. Studies can focus on its glutamatergic projections, termination in the dentate gyrus, and relationship to synaptic plasticity, learning, and pattern separation. These features help connect pathway activity with broader mechanisms of hippocampal function.
The pathway provides a way to investigate how spatial and contextual information enters hippocampal circuits. Its connections with dentate gyrus and CA3 regions make it relevant to questions about memory-related processing, pattern separation, synaptic plasticity, learning, and navigation. Researchers can therefore use it to relate entorhinal signals to hippocampal behavioral functions.
The medial perforant path is relevant because it participates in hippocampal processing linked to memory and learning, while its circuit position also makes it informative for studying hippocampal dysfunction. Research can examine how this entorhinal-to-hippocampal connection relates to disorders involving memory, epilepsy, or neurodegeneration, without treating the pathway as an isolated structure.