Coronary Blood Flow
Coronary Blood Flow - Related Videos
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Cited by 20 •
2015
Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
03:38
Developing a Cerebral Blood Flow Atlas for Blood Flow Mapping
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2025
Source: Tan, Z., et al., Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling. J. Vis. Exp. (2024).This video demonstrates the method to construct a cerebral blood flow atlas by integrating magnetic resonance imaging or MRI-arterial spin labeling data with segmented brain regions, visualizing blood flow patterns, and quantifying flow levels across functional areas.
01:29
Blood Flow
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2025
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow. Slow...
12:39
Computational Fluid Dynamics Simulations of Blood Flow in a Cerebral Aneurysm
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2023
Source: Joseph C. Muskat, Vitaliy L. Rayz, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana The objective of this video is to describe recent advancements of computational fluid dynamic (CFD) simulations based on patient- or animal-specific vasculature. Here, subject-based vessel segmentations were created, and, using a combination of open-source and commercial tools, a high-resolution numerical solution was determined within a flow model.
07:36
Isolation of Mouse Coronary Endothelial Cells
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Cited by 18 •
2016
This protocol is prepared to share our method of isolating mouse coronary endothelial cells for the purpose of imaging or to conduct molecular biological experiments.
FAQs
During systole, contraction of the ventricular muscle compresses intramyocardial vessels and limits passage through parts of the coronary circulation. When the ventricle relaxes during diastole, this mechanical compression decreases, allowing more effective perfusion. The timing of cardiac contraction therefore helps determine when oxygen delivery to the myocardium is greatest.
An increase in myocardial oxygen demand promotes local adjustments that reduce coronary resistance and support greater blood delivery. These adjustments help match perfusion with the metabolic needs of the working heart. In pharmacology, this relationship is important because a drug can affect coronary flow indirectly by changing cardiac workload, not only by acting on vascular smooth muscle.
Local metabolites provide signals related to myocardial activity, while the endothelium contributes regulatory signals that influence nearby vascular smooth muscle. Smooth-muscle tone then changes vessel resistance and alters the amount of blood reaching the myocardium. Together, these mechanisms connect tissue demand and vessel behavior, making coronary regulation responsive to changing cardiac conditions.
Drug effects on coronary flow may result from several linked actions. Vasodilators can reduce vascular resistance, whereas beta-adrenergic drugs and other cardiovascular agents may also modify cardiac workload and oxygen demand. The resulting change in flow depends on how altered vascular tone, oxygen delivery, and myocardial work interact rather than on vessel dilation alone.
Researchers measure changes in coronary flow to examine drug efficacy and cardiovascular effects. The findings can indicate whether treatment alters coronary resistance or oxygen delivery, and they can be interpreted alongside changes in cardiac workload. This approach helps characterize intended actions as well as potentially adverse effects of cardiovascular agents.
Ischemia and angina are important contexts for examining whether myocardial oxygen delivery adequately matches cardiac demand. Assessing coronary flow can help investigators study this balance and determine how pharmacological interventions affect it. Flow measurements therefore provide a functional outcome for comparing drug responses, investigating impaired perfusion, and evaluating cardiovascular safety.