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Medicine
缺血性心力衰竭在临床前模型的转基因
缺血性心力衰竭在临床前模型的转基因
JoVE Journal
Medicine
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JoVE Journal Medicine
Gene Transfer for Ischemic Heart Failure in a Preclinical Model

缺血性心力衰竭在临床前模型的转基因

Full Text
13,374 Views
07:35 min
May 15, 2011

DOI: 10.3791/2778-v

Kiyotake Ishikawa1, Dennis Ladage1, Lisa Tilemann1, Kenneth Fish1, Yoshiaki Kawase1, Roger J. Hajjar1

1Cardiovascular Research Center,Mount Sinai School of Medicine

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Please note that some of the translations on this page are AI generated. Click here for the English version.

一个基因转染对缺血性心力衰竭的治疗方法是用一个猪心肌梗死模型。我们的简单和可重复性的方法,使我们能够很容易用一个非常简单和重复性的方式评估各种基因转移的疗效。

基因治疗。使用病毒载体是治疗心脏病最有前途的方法之一。本视频介绍了我们创建的缺血性心力衰竭模型的程序,以及病毒载体的基因递送。

第一步是在猪模型中创建心肌梗死。为此,将冠状动脉导丝引入冠状动脉,然后是闭塞球囊。使用血管内重点,球囊将被充气以完全阻塞冠状动脉。

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