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Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Article DOI: 10.3791/50864-v • 07:35 min • February 4th, 2014
February 4th, 2014 •
1,2, 1,2
1Department of Psychiatry, Harvard Medical School, 2Mailman Research Center, McLean Hospital

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Approaches for testing the effects of antipsychotic drugs (APDs) in Caenorhabditis elegans are demonstrated. Assays are described for testing drug effects on development and viability and on pharyngeal pumping rate. These methods are also applicable for pharmacogenetic experiments with drug classes other than APDs.

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Caenorhabditis Elegans Antipsychotic Drugs Mechanisms Of Action Genetic Screens Chemical Genetic Screens APD Targets Neurotransmitter Synthesis Synaptic Structure And Function Developmental Delay Lethality Pharyngeal Pumping Neuromuscular Basis Pharmacogenetic Studies Nematode Development Pharyngeal Pumping Rate Assay Small Molecules Large Molecules
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